AC T00141
XX
ID T00141
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DT 26.01.1993 (created); hse.
DT 21.01.2016 (updated); sup.
CO Copyright (C), QIAGEN.
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FA c-Myc
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SY c-Myc.
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OS chick, Gallus gallus
OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; neognathae; galliformes; phasianidae
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GE G000073 MYC.
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CL C0012; bHLH-ZIP.
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SZ 416 AA; 46.0 kDa (cDNA) (calc.), 59-62 kDa (SDS) [7]
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SQ MPLSASLPSKNYDYDYDSVQPYFYFEEEEENFYLAAQQRGSELQPPAPSEDIWKKFELLP
SQ TPPLSPSRRSSLAAASCFPSTADQLEMVTELLGGDMVNQSFICDPDDESFVKSIIIQDCM
SQ WSGFSAAAKLEKVVSEKLATYQASRREGGPAAASRPGPPPSGPPPPPAGPAASAGLYLHD
SQ LGAAAADCIDPSVVFPYPLSERAPRAAPPGANPAALLGVDTPPTTSSDSEEEQEEDEEID
SQ VVTLAEANESESSTESSTEASEEHCKPHHSPLVLKRCHVNIHQHNYAAPPSTKVEYPAAK
SQ RLKLDSGRVLKQISNNRKCSSPRTSDSEENDKRRTHNVLERQRRNELKLSFFALRDQIPE
SQ VANNEKAPKVVILKKATEYVLSIQSDEHRLIAEKEQLRRRREQLKHKLEQLRNSRA
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SC Swiss-Prot#P01109
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FT 1 322 
PF01056; Myc amino-terminal region.
FT 61 61 
threonine-phosphorylation [8].
FT 65 65 
serine-phosphorylation [8].
FT 331 384 
PS50888; HLH.
FT 332 384 
PF00010; Helix-loop-helix DNA-binding domain.
FT 337 389 
SM00353; finulus.
FT 385 416 
PF02344; Myc leucine zipper domain.
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CP differentiating and proliferating chondrocytes [13].
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FF role in cell proliferation and differentiation of chondrocytes [13];
FF c-myc gene is involved in the development of B-cell lymphomas [9] [10] [11];
FF phosphorylation may enhance trans-activation and may down-regulate transformation activity [8];
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IN T00141 c-Myc; chick, Gallus gallus.
IN T00489 Max-isoform2; human, Homo sapiens.
IN T00523 Max; mouse, Mus musculus.
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MX M01145 V$CMYC_01.
MX M01154 V$CMYC_02.
MX M07601 V$CMYC_Q3.
MX M03867 V$CMYC_Q6_01.
MX M01034 V$EBOX_Q6_01.
MX M00118 V$MYCMAX_01.
MX M00123 V$MYCMAX_02.
MX M00615 V$MYCMAX_03.
MX M00322 V$MYCMAX_B.
MX M00799 V$MYC_Q2.
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BS R02207.
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DR TRANSPATH: MO000024728.
DR EMBL: J00889;
DR UniProtKB: P01109;
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RN [1]; RE0000173.
RX PUBMED: 1840505.
RA Prendergast G. C., Lawe D., Ziff E. B.
RT Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation
RL Cell 65:395-407 (1991).
RN [2]; RE0000428.
RX PUBMED: 2686984.
RA Ariga H., Imamura Y., Iguchi-Ariga S. M. M.
RT DNA replication origin and transcriptional enhancer in c-myc gene share the c-myc protein binding sequences
RL EMBO J. 8:4273-4279 (1989).
RN [3]; RE0001483.
RX PUBMED: 1990293.
RA Dang C. V., Barrett J., Villa-Garcia M., Resar L. M. S., Kato G. J., Fearon E. R.
RT Intracellular leucine zipper interactions suggest c-Myc hetero-oligomerization
RL Mol. Cell. Biol. 11:954-962 (1991).
RN [4]; RE0002652.
RX PUBMED: 2251503.
RA Blackwell T. K., Kretzner L., Blackwood E. M., Eisenman R. N., Weintraub H.
RT Sequence-specific DNA binding by the c-Myc protein
RL Science 250:1149-1151 (1990).
RN [5]; RE0002653.
RX PUBMED: 2006410.
RA Blackwood E. M., Eisenman R. N.
RT Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc
RL Science 251:1211-1217 (1991).
RN [6]; RE0003336.
RX PUBMED: 1989881.
RA Eilers M., Schirm S., Bishop J. M.
RT The MYC protein activates transcription of the a-prothymosin gene
RL EMBO J. 10:133-141 (1991).
RN [7]; RE0003343.
RX PUBMED: 1628829.
RA Hann S. R., Sloan-Brown K., Spotts G. D.
RT Translational activation of the non-AUG-initiated c-myc 1 protein at high cell densities due to methionine deprivation
RL Genes Dev. 6:1229-1240 (1992).
RN [8]; RE0003354.
RX PUBMED: 8247524.
RA Henriksson M., Bakardjiev A., Klein G., Luescher B.
RT Phosphorylation sites mapping in the N-terminal domain of c-myc modulate its transforming potential
RL Oncogene 8:3199-3209 (1993).
RN [9]; RE0003443.
RX PUBMED: 6158786.
RA Sheiness D. K., Hughes S. H., Varmus H. E., Stubblefield E., Bishop J. M.
RT The Vertebrate Homology of the Putative Transforming Gene of Avian Myelocytomatosis Virus: Characteristics of the DNA Locus and Its RNA Transcript
RL Virology 105:415-424 (1980).
RN [10]; RE0003444.
RX PUBMED: 6258797.
RA Payne G. S., Courtneidge S. A., Crittenden L. B., Fadly A. M., Bishop J. M., Varmus H. E.
RT Analysis of Avian Leukosis Virus DNA and RNA in Bursal Tumors: Viral Gene Expression Is Not Required for Maintenance of the Tumor State
RL Cell 23:311-322 (1981).
RN [11]; RE0003445.
RX PUBMED: 6258798.
RA Neel B. G., Hayward W. S., Robinson H. L., Fang J., Astrin S. M.
RT Avian Leukosis Virus-Induced Tumors Have Common Proviral Integration Sites and Synthesize Discrete New RNAs: Oncogenesis by Promoter Insertion
RL Cell 23:323-334 (1981).
RN [12]; RE0003453.
RX PUBMED: 6300896.
RA Watson D. K., Reddy E. P., Duesberg P. H., Papas T. S.
RT Nucleotide sequence analysis of the chicken c-myc gene reveals homologous and unique coding regions by comparison with the transforming gene of avian myelocytomatosis virus MC29, delta-gag-myc
RL Proc. Natl. Acad. Sci. USA 80:2146-2150 (1983).
RN [13]; RE0014487.
RX PUBMED: 1618915.
RA Farquharson C., Hesketh J. E., Loveridge N.
RT The proto-oncogene c-myc is involved in cell differentiation as well as cell proliferation: studies on growth plate chondrocytes in situ
RL J. Cell. Physiol. 152:135-144 (1992).
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