AC T03268
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ID T03268
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DT 02.05.2000 (created); sth.
DT 21.09.2007 (updated); tgo.
CO Copyright (C), QIAGEN.
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FA Rox
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SY MNT (MAX binding protein).
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004561 MNT; HGNC: MNT.
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CL C0012; bHLH-ZIP; 1.2.6.7.6.
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SF MNT (MAX binding protein), efficient DNA binding requires dimerization with another bHLH protein;
SF binds DNA as an homodimer or a heterodimer with Max;
SF nuclear localization;
SF binds to the canonical E box sequence 5'-CACGTG-3' and with higher affinity, to 5'-CACGCG-3' [1];
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CP quiescent fibroblasts.
EX brain,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX heart,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX kidney (right and left),,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX liver,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX lung (right and left),,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX muscles,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX spleen,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX testis (right and left),,,adult; detectable; Northern blot; mRNA (poly-A); [1].
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FF transcriptional regulator [1];
FF binds DNA as a heterodimer with Max and represses transcription;
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IN T00489 Max-isoform2; human, Homo sapiens.
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DR TRANSPATH: MO000027206.
DR UniProtKB: Q99583;
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RN [1]; RE0014442.
RX PUBMED: 9184233.
RA Meroni G., Reymond A., Alcalay M., Borsani G., Tanigami A., Tonlorenzi R., Nigro C. L., Messali S., Zollo M., Ledbetter D. H., Brent R., Ballabio A., Carrozzo R.
RT Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor
RL EMBO J. 16:2892-2906 (1997).
RN [2]; RE0014461.
RX PUBMED: 9598315.
RA Nigro C. L., Venesio T., Reymond A., Meroni G., Alberici P., Cainarca S., Enrico F., Stack M., Ledbetter D. H., Liscia D. S., Ballabio A., Carrozzo R.
RT The human ROX gene: genomic structure and mutation analysis in human breast tumors
RL Genomics 49:275-282 (1998).
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