TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01445 XX ID T01445 XX DT 13.04.1995 (created); ewi. DT 04.07.2011 (updated); shs. CO Copyright (C), QIAGEN. XX FA N-Myc XX SY c-nmyc; N-myc; neuroblastoma myc-related oncogene 1; NMYC; Nmyc-1; Nmyc1. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G001167 Mycn. XX CL C0012; bHLH-ZIP; XX SF phosphorylation; SF the basic region determines its DNA-binding specificity which is similar to that of c-Myc [2] [4]; XX CP (embryo:) visceral arches, gut/intestines, kidney, lung, thymus, CNS, PNS; very low levels in limbs (late fetal stages), somites and skin, heart [3]. CN liver [3]. XX FF involved in control of proliferation and differentiation; FF aberrant expression may cause neoplasm; XX IN T01567 Max-isoform1; human, Homo sapiens. IN T00489 Max-isoform2; human, Homo sapiens. IN T00523 Max; mouse, Mus musculus. IN T09085 Max; Mammalia. IN T00722 pRb; human, Homo sapiens. XX MX M01034 V$EBOX_Q6_01. MX M02259 V$MYCN_01. MX M00055 V$NMYC_01. MX M01808 V$NMYC_02. MX M03834 V$NMYC_Q3. XX BS R33398. BS R04649. XX DR TRANSPATH: MO000025670. DR UniProtKB: P03966; XX RN [1]; RE0001865. RX PUBMED: 1865909. RA Rustgi A. K., Dyson N., Bernards R. RT Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product RL Nature 352:541-544 (1991). RN [2]; RE0002923. RX PUBMED: 1594445. RA Alex R., Soezeri O., Meyer S., Dildrop R. RT Determination of the DNA sequence recognized by the bHLH-zip domain of the N-Myc protein RL Nucleic Acids Res. 20:2257-2263 (1992). RN [3]; RE0003374. RX PUBMED: 1459449. RA Stanton B. R., Perlins A. S., Tessarollo L., Sassoon D. A., Parada L. F. RT Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop RL Genes Dev. 6:2235-2247 (1992). RN [4]; RE0003379. RX PUBMED: 7902977. RA Feldmann T., Alex R., Suckow J., Dildrop R., Kisters-Woike B., Mueller-Hill B. RT Single exchanges of amino acids in the basic region change the specificity of N-Myc RL Nucleic Acids Res. 21:5050-5058 (1993). RN [5]; RE0006775. RX PUBMED: 3015591. RA Taya Y., Mizusawa S., Nishimura S. RT Nucleotide sequence of the coding region of the mouse N-myc gene RL EMBO J. 5:1215-1219 (1986). RN [6]; RE0006776. RX PUBMED: 3513190. RA DePinho R. A., Legouy E., Feldman L. B., Kohl N. E., Yancopoulos G. D., Alt F. W. RT Structure and expression of the murine N-myc gene RL Proc. Natl. Acad. Sci. USA 83:1827-1831 (1986). RN [7]; RE0006786. RX PUBMED: 8521822. RA Hurlin P. J., Queva C., Koskinen P. J., Steingrimsson E., Ayer D. E., Copeland N. G., Jenkins N. A., Eisenman R. N. RT Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation RL EMBO J. 14:5646-5659 (1995). RN [8]; RE0048383. RX PUBMED: 16139224. RA Sjostrom S. K., Finn G., Hahn W. C., Rowitch D. H., Kenney A. M. RT The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors. RL Dev. Cell 9:327-338 (2005). RN [9]; RE0067022. RX PUBMED: 16054035. RA Mill P., Mo R., Hu M. C., Dagnino L., Rosenblum N. D., Hui C. C. RT Shh controls epithelial proliferation via independent pathways that converge on N-Myc. RL Dev. Cell 9:293-303 (2005). RN [10]; RE0069431. RX PUBMED: 18488021. RA Zhao X., Heng J. I., Guardavaccaro D., Jiang R., Pagano M., Guillemot F., Iavarone A., Lasorella A. RT The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein. RL Nat. Cell Biol. 10:643-653 (2008). XX //