AC T01445
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ID T01445
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DT 13.04.1995 (created); ewi.
DT 04.07.2011 (updated); shs.
CO Copyright (C), QIAGEN.
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FA N-Myc
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SY c-nmyc; N-myc; neuroblastoma myc-related oncogene 1; NMYC; Nmyc-1; Nmyc1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G001167 Mycn.
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CL C0012; bHLH-ZIP; 1.2.6.5.2.
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SF phosphorylation;
SF the basic region determines its DNA-binding specificity which is similar to that of c-Myc [2] [4];
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CP (embryo:) visceral arches, gut/intestines, kidney, lung, thymus, CNS, PNS; very low levels in limbs (late fetal stages), somites and skin, heart [3].
CN liver [3].
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FF involved in control of proliferation and differentiation;
FF aberrant expression may cause neoplasm;
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IN T01567 Max-isoform1; human, Homo sapiens.
IN T00489 Max-isoform2; human, Homo sapiens.
IN T00523 Max; mouse, Mus musculus.
IN T09085 Max; Mammalia.
IN T00722 pRb; human, Homo sapiens.
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MX M01034 V$EBOX_Q6_01.
MX M02259 V$MYCN_01.
MX M00055 V$NMYC_01.
MX M01808 V$NMYC_02.
MX M03834 V$NMYC_Q3.
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BS R33398.
BS R04649.
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DR TRANSPATH: MO000025670.
DR UniProtKB: P03966;
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RN [1]; RE0001865.
RX PUBMED: 1865909.
RA Rustgi A. K., Dyson N., Bernards R.
RT Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product
RL Nature 352:541-544 (1991).
RN [2]; RE0002923.
RX PUBMED: 1594445.
RA Alex R., Soezeri O., Meyer S., Dildrop R.
RT Determination of the DNA sequence recognized by the bHLH-zip domain of the N-Myc protein
RL Nucleic Acids Res. 20:2257-2263 (1992).
RN [3]; RE0003374.
RX PUBMED: 1459449.
RA Stanton B. R., Perlins A. S., Tessarollo L., Sassoon D. A., Parada L. F.
RT Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop
RL Genes Dev. 6:2235-2247 (1992).
RN [4]; RE0003379.
RX PUBMED: 7902977.
RA Feldmann T., Alex R., Suckow J., Dildrop R., Kisters-Woike B., Mueller-Hill B.
RT Single exchanges of amino acids in the basic region change the specificity of N-Myc
RL Nucleic Acids Res. 21:5050-5058 (1993).
RN [5]; RE0006775.
RX PUBMED: 3015591.
RA Taya Y., Mizusawa S., Nishimura S.
RT Nucleotide sequence of the coding region of the mouse N-myc gene
RL EMBO J. 5:1215-1219 (1986).
RN [6]; RE0006776.
RX PUBMED: 3513190.
RA DePinho R. A., Legouy E., Feldman L. B., Kohl N. E., Yancopoulos G. D., Alt F. W.
RT Structure and expression of the murine N-myc gene
RL Proc. Natl. Acad. Sci. USA 83:1827-1831 (1986).
RN [7]; RE0006786.
RX PUBMED: 8521822.
RA Hurlin P. J., Queva C., Koskinen P. J., Steingrimsson E., Ayer D. E., Copeland N. G., Jenkins N. A., Eisenman R. N.
RT Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation
RL EMBO J. 14:5646-5659 (1995).
RN [8]; RE0048383.
RX PUBMED: 16139224.
RA Sjostrom S. K., Finn G., Hahn W. C., Rowitch D. H., Kenney A. M.
RT The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors.
RL Dev. Cell 9:327-338 (2005).
RN [9]; RE0067022.
RX PUBMED: 16054035.
RA Mill P., Mo R., Hu M. C., Dagnino L., Rosenblum N. D., Hui C. C.
RT Shh controls epithelial proliferation via independent pathways that converge on N-Myc.
RL Dev. Cell 9:293-303 (2005).
RN [10]; RE0069431.
RX PUBMED: 18488021.
RA Zhao X., Heng J. I., Guardavaccaro D., Jiang R., Pagano M., Guillemot F., Iavarone A., Lasorella A.
RT The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein.
RL Nat. Cell Biol. 10:643-653 (2008).
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