TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02379 XX ID T02379 XX DT 03.04.1998 (created); ewi. DT 05.03.2015 (updated); hna. CO Copyright (C), QIAGEN. XX FA N-Myc XX SY MYCN; N-myc proto-oncogene protein; NMYC. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004698 MYCN; HGNC: MYCN. XX CL C0012; bHLH-ZIP; XX SF phosphorylation causes the appearance of isoforms with higher apparent molecular weight [4]; SF the existence two alternative translation initiation codons causes the synthesis of an additional 458 AA-polypeptide [4]; SF the basic region determines its DNA-binding specificity which is similar to that of c-Myc [1]; SF very similar gene structure as c-myc [2] [3]; XX FF involved in control of proliferation and differentiation; FF aberrant expression may cause neoplasm [1]; XX IN T01567 Max-isoform1; human, Homo sapiens. IN T00489 Max-isoform2; human, Homo sapiens. IN T00523 Max; mouse, Mus musculus. IN T03483 Nmi; human, Homo sapiens. XX MX M01034 V$EBOX_Q6_01. MX M00055 V$NMYC_01. MX M01808 V$NMYC_02. MX M03834 V$NMYC_Q3. XX BS R37967. BS R73559. BS R34894. BS R73560. BS R73562. BS R73563. BS R73561. BS R25403. BS R36831. BS R36833. BS R71180. BS R34907. BS R66593. BS R66595. BS R66596. BS R04649. XX DR TRANSPATH: MO000026369. DR UniProtKB: P04198; XX RN [1]; RE0003379. RX PUBMED: 7902977. RA Feldmann T., Alex R., Suckow J., Dildrop R., Kisters-Woike B., Mueller-Hill B. RT Single exchanges of amino acids in the basic region change the specificity of N-Myc RL Nucleic Acids Res. 21:5050-5058 (1993). RN [2]; RE0003439. RX PUBMED: 2869488. RA Stanton L. W., Schwab M., Bishop J. M. RT Nucleotide sequence of the human N-myc gene RL Proc. Natl. Acad. Sci. USA 86:1772-1776 (1986). RN [3]; RE0006766. RX PUBMED: 3008339. RA Slamon D. J., Boone T. C., Seeger R. C., Keith D. E., Chazin V., Lee H. C., Souza L. M. RT Identification and characterization of the protein encoded by the human N-myc oncogene RL Science 232:768-772 (1986). RN [4]; RE0006771. RX PUBMED: 2657399. RA Maekelae T. P., Saksela K., Alitalo K. RT Two N-myc polypeptides with distinct amino-termini encoded by the second and third exons of the gene RL Mol. Cell. Biol. 9:1545-1552 (1989). RN [5]; RE0069431. RX PUBMED: 18488021. RA Zhao X., Heng J. I., Guardavaccaro D., Jiang R., Pagano M., Guillemot F., Iavarone A., Lasorella A. RT The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein. RL Nat. Cell Biol. 10:643-653 (2008). XX //