AC T02379
XX
ID T02379
XX
DT 03.04.1998 (created); ewi.
DT 05.03.2015 (updated); hna.
CO Copyright (C), QIAGEN.
XX
FA N-Myc
XX
SY MYCN; N-myc proto-oncogene protein; NMYC.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G004698 MYCN; HGNC: MYCN.
XX
CL C0012; bHLH-ZIP; 1.2.6.5.2.
XX
SF phosphorylation causes the appearance of isoforms with higher apparent molecular weight [4];
SF the existence two alternative translation initiation codons causes the synthesis of an additional 458 AA-polypeptide [4];
SF the basic region determines its DNA-binding specificity which is similar to that of c-Myc [1];
SF very similar gene structure as c-myc [2] [3];
XX
FF involved in control of proliferation and differentiation;
FF aberrant expression may cause neoplasm [1];
XX
IN T01567 Max-isoform1; human, Homo sapiens.
IN T00489 Max-isoform2; human, Homo sapiens.
IN T00523 Max; mouse, Mus musculus.
IN T03483 Nmi; human, Homo sapiens.
XX
MX M01034 V$EBOX_Q6_01.
MX M00055 V$NMYC_01.
MX M01808 V$NMYC_02.
MX M03834 V$NMYC_Q3.
XX
BS R37967.
BS R73559.
BS R34894.
BS R73560.
BS R73562.
BS R73563.
BS R73561.
BS R25403.
BS R36831.
BS R36833.
BS R71180.
BS R34907.
BS R66593.
BS R66595.
BS R66596.
BS R04649.
XX
DR TRANSPATH: MO000026369.
DR UniProtKB: P04198;
XX
RN [1]; RE0003379.
RX PUBMED: 7902977.
RA Feldmann T., Alex R., Suckow J., Dildrop R., Kisters-Woike B., Mueller-Hill B.
RT Single exchanges of amino acids in the basic region change the specificity of N-Myc
RL Nucleic Acids Res. 21:5050-5058 (1993).
RN [2]; RE0003439.
RX PUBMED: 2869488.
RA Stanton L. W., Schwab M., Bishop J. M.
RT Nucleotide sequence of the human N-myc gene
RL Proc. Natl. Acad. Sci. USA 86:1772-1776 (1986).
RN [3]; RE0006766.
RX PUBMED: 3008339.
RA Slamon D. J., Boone T. C., Seeger R. C., Keith D. E., Chazin V., Lee H. C., Souza L. M.
RT Identification and characterization of the protein encoded by the human N-myc oncogene
RL Science 232:768-772 (1986).
RN [4]; RE0006771.
RX PUBMED: 2657399.
RA Maekelae T. P., Saksela K., Alitalo K.
RT Two N-myc polypeptides with distinct amino-termini encoded by the second and third exons of the gene
RL Mol. Cell. Biol. 9:1545-1552 (1989).
RN [5]; RE0069431.
RX PUBMED: 18488021.
RA Zhao X., Heng J. I., Guardavaccaro D., Jiang R., Pagano M., Guillemot F., Iavarone A., Lasorella A.
RT The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein.
RL Nat. Cell Biol. 10:643-653 (2008).
XX
//