TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00142 XX ID T00142 XX DT 26.01.1993 (created); hse. DT 04.07.2013 (updated); yre. CO Copyright (C), QIAGEN. XX FA c-Myc XX SY c-Myc. XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G001042 Myc. XX CL C0012; bHLH-ZIP; XX SF Myc proto-oncogene protein [3]; SF efficient DNA binding requires dimerization with another bHLH protein; SF binds DNA as an heterodimer with Max; SF binds DNA both in a non-specific manner and also specifically to recognizes the core sequence CAC(GA)TG [3]; XX CP differentiating and proliferating chondrocytes [5]. XX FF participates in the regulation of gene transcription of growth-related genes [3]; FF role in cell proliferation and differentiation of chondrocytes [5]; FF induces apoptosis in the absence of certain growth factors [4]; FF positively regulates the genes for translation initiation factors eIF-4E and -2alpha [2]; XX IN T00142 c-Myc; rat, Rattus norvegicus. IN T00489 Max-isoform2; human, Homo sapiens. IN T00523 Max; mouse, Mus musculus. IN T05668 Nrf2; rat, Rattus norvegicus. XX MX M01145 V$CMYC_01. MX M01154 V$CMYC_02. MX M07601 V$CMYC_Q3. MX M03867 V$CMYC_Q6_01. MX M01034 V$EBOX_Q6_01. MX M00118 V$MYCMAX_01. MX M00123 V$MYCMAX_02. MX M00615 V$MYCMAX_03. MX M00322 V$MYCMAX_B. MX M00799 V$MYC_Q2. XX BS R31427. BS R36289. BS R09594. BS R09595. BS R55835. BS R02207. BS R41833. BS R35976. BS R35979. BS R35993. BS R36360. BS R36361. XX DR TRANSPATH: MO000024729. DR UniProtKB: P09416; XX RN [1]; RE0000428. RX PUBMED: 2686984. RA Ariga H., Imamura Y., Iguchi-Ariga S. M. M. RT DNA replication origin and transcriptional enhancer in c-myc gene share the c-myc protein binding sequences RL EMBO J. 8:4273-4279 (1989). RN [2]; RE0003356. RX PUBMED: 8327497. RA Rosenwald I. B., Rhoads D. B., Callanan L. D., Isselbacher K. J., Schmidt E. V. RT Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2a in response to growth induction by c-myc RL Proc. Natl. Acad. Sci. USA 90:6175-6178 (1993). RN [3]; RE0003454. RX PUBMED: 3306601. RA Hayashi K., Makino R., Kawamura H., Arisawa A., Yoneda K. RT Characterization of rat c-myc and adjacent region RL Nucleic Acids Res. 15:6419-6436 (1987). RN [4]; RE0003455. RX PUBMED: 1555236. RA Evan G. I., Wyllie A. H., Gilbert C. S., Littlewood T. D., Land H., Brooks M., Waters C. M., Penn L. Z., Hancock D. C. RT Induction of apoptosis in fibroblasts by c-myc protein RL Cell 69:119-128 (1992). RN [5]; RE0014487. RX PUBMED: 1618915. RA Farquharson C., Hesketh J. E., Loveridge N. RT The proto-oncogene c-myc is involved in cell differentiation as well as cell proliferation: studies on growth plate chondrocytes in situ RL J. Cell. Physiol. 152:135-144 (1992). RN [6]; RE0014686. RX PUBMED: 9162900. RA Walhout A. J., Gubbels J. M., Bernards R., van der Vliet P. C., Timmers H. T. RT c-Myc/Max heterodimers bind cooperatively to the E-box sequences located in the first intron of the rat ornithine decarboxylase (ODC) gene RL Nucleic Acids Res. 15:1493-1501 (1997). RN [7]; RE0047993. RX PUBMED: 12873812. RA Tinel M., Berson A., Elkahwaji J., Cresteil T., Beaune P., Pessayre D. RT Downregulation of cytochromes P450 in growth-stimulated rat hepatocytes: role of c-Myc induction and impaired C/EBP binding to DNA. RL J. Hepatology 39:171-178 (2003). RN [8]; RE0069454. RX PUBMED: 21187408. RA Boone D. N., Qi Y., Li Z., Hann S. R. RT Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism. RL Proc. Natl. Acad. Sci. USA 108:632-637 (2011). XX //