AC T01565
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ID T01565
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DT 19.09.1995 (created); ewi.
DT 08.07.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA Mad1
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SY BHLHC58; Mad; MAD1; Max dimerization protein; MAX dimerization protein 1; MGC104659; MXD1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003957 MXD1; HGNC: MXD1.
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CL C0012; bHLH-ZIP; 1.2.6.7.1.
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SF bHLH domain is most similar to Emc, Hairy and Mxi1;
SF interacting with Max (not: c-myc) to produce a DNA-binding heterodimer with increased affinity in vitro and in vivo [2] [3];
SF probably group B HLH-protein that bind to CACGTG motif in DNA due to certain residues in DNA-binding domain (His at pos. 61, Glu at pos. 65, Arg at pos. 69) and thus homology to MAX T05056, T00489>, T01567 in this region [4];
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FF heterodimer with Max is a transcriptional repressor via competition for common DNA binding sites [1];
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IN T01567 Max-isoform1; human, Homo sapiens.
IN T00489 Max-isoform2; human, Homo sapiens.
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MX M01034 V$EBOX_Q6_01.
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DR TRANSPATH: MO000025770.
DR UniProtKB: Q05195;
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RN [1]; RE0003363.
RX PUBMED: 8202517.
RA Lahoz E. G., Xu L., Schreiber-Agus N., DePinho R. A.
RT Suppression of Myc, but not E1a, transformation activity by Max-associated proteins, Mad and Mxi1
RL Proc. Natl. Acad. Sci. USA 91:5503-5507 (1994).
RN [2]; RE0003401.
RX PUBMED: 8425218.
RA Ayer D. E., Kretzner L., Eisenman R. N.
RT Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity
RL Cell 72:211-222 (1993).
RN [3]; RE0003403.
RX PUBMED: 8224841.
RA Ayer D. E., Eisenman R. N.
RT A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation
RL Genes Dev. 7:2110-2119 (1993).
RN [4]; RE0017817.
RX PUBMED: 11073985.
RA Billin A. N., Eilers A. L., Coulter K. L., Logan J. S., Ayer D. E.
RT MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network
RL Mol. Cell. Biol. 20:8845-8854 (2000).
RN [5]; RE0030480.
RX PUBMED: 14611815.
RA Xiao X., Athanasiou M., Sidorov I. A., Horikawa I., Cremona G., Blair D., Barret J. C., Dimitrov D. S.
RT Role of Ets/Id proteins for telomerase regulation in human cancer cells.
RL Exp. Mol. Pathol. 75:238-47 (2003).
RN [6]; RE0050216.
RX PUBMED: 15257285.
RA Xia G., Luo X., Habu T., Rizo J., Matsumoto T., Yu H.
RT Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint.
RL EMBO J. 23:3133-3143 (2004).
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