TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01565 XX ID T01565 XX DT 19.09.1995 (created); ewi. DT 08.07.2014 (updated); yre. CO Copyright (C), QIAGEN. XX FA Mad1 XX SY BHLHC58; Mad; MAD1; Max dimerization protein; MAX dimerization protein 1; MGC104659; MXD1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G003957 MXD1; HGNC: MXD1. XX CL C0012; bHLH-ZIP; XX SF bHLH domain is most similar to Emc, Hairy and Mxi1; SF interacting with Max (not: c-myc) to produce a DNA-binding heterodimer with increased affinity in vitro and in vivo [2] [3]; SF probably group B HLH-protein that bind to CACGTG motif in DNA due to certain residues in DNA-binding domain (His at pos. 61, Glu at pos. 65, Arg at pos. 69) and thus homology to MAX T05056, T00489>, T01567 in this region [4]; XX FF heterodimer with Max is a transcriptional repressor via competition for common DNA binding sites [1]; XX IN T01567 Max-isoform1; human, Homo sapiens. IN T00489 Max-isoform2; human, Homo sapiens. XX MX M01034 V$EBOX_Q6_01. XX DR TRANSPATH: MO000025770. DR UniProtKB: Q05195; XX RN [1]; RE0003363. RX PUBMED: 8202517. RA Lahoz E. G., Xu L., Schreiber-Agus N., DePinho R. A. RT Suppression of Myc, but not E1a, transformation activity by Max-associated proteins, Mad and Mxi1 RL Proc. Natl. Acad. Sci. USA 91:5503-5507 (1994). RN [2]; RE0003401. RX PUBMED: 8425218. RA Ayer D. E., Kretzner L., Eisenman R. N. RT Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity RL Cell 72:211-222 (1993). RN [3]; RE0003403. RX PUBMED: 8224841. RA Ayer D. E., Eisenman R. N. RT A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation RL Genes Dev. 7:2110-2119 (1993). RN [4]; RE0017817. RX PUBMED: 11073985. RA Billin A. N., Eilers A. L., Coulter K. L., Logan J. S., Ayer D. E. RT MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network RL Mol. Cell. Biol. 20:8845-8854 (2000). RN [5]; RE0030480. RX PUBMED: 14611815. RA Xiao X., Athanasiou M., Sidorov I. A., Horikawa I., Cremona G., Blair D., Barret J. C., Dimitrov D. S. RT Role of Ets/Id proteins for telomerase regulation in human cancer cells. RL Exp. Mol. Pathol. 75:238-47 (2003). RN [6]; RE0050216. RX PUBMED: 15257285. RA Xia G., Luo X., Habu T., Rizo J., Matsumoto T., Yu H. RT Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint. RL EMBO J. 23:3133-3143 (2004). XX //