AC T02385
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ID T02385
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DT 07.04.1998 (created); ewi.
DT 19.11.2007 (updated); djp.
CO Copyright (C), QIAGEN.
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FA L-Myc-1(long form)
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SY L-Myc-1 proto-oncogene protein.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004699 MYCL; HGNC: MYCL.
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CL C0012; bHLH-ZIP; 1.2.6.5.3.1.
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SZ 364 AA; 40.3 kDa (gene) (calc.).
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SQ MDYDSYQHYFYDYDCGEDFYRSTAPSEDIWKKFELVPSPPTSPPWGLGPGAGDPAPGIGP
SQ PEPWPGGCTGDEAESRGHSKGWGRNYASIIRRDCMWSGFSARERLERAVSDRLAPGAPRG
SQ NPPKASAAPDCTPSLEAGNPAPAAPCPLGEPKTQACSGSESPSDSENEEIDVVTVEKRQS
SQ LGIRKPVTITVRADPLDPCMKHFHISIHQQQHNYAARFPPESCSQEEASERGPQEEVLER
SQ DAAGEKEDEEDEEIVSPPPVESEAAQSCHPKPVSSDTEDVTKRKNHNFLERKRRNDLRSR
SQ FLALRDQVPTLASCSKAPKVVILSKALEYLQALVGAEKRMATEKRQLRCRQQQLQKRIAY
SQ LSGY
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SC translated from EMBL #M19720
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FT 1 257 
PF01056; Myc amino-terminal region.
FT 166 364 
replaced by 166-206 in L-Myc-1 (short form) [8].
FT 282 334 
PF00010; Helix-loop-helix DNA-binding domain.
FT 282 334 
PS50888; HLH.
FT 287 339 
SM00353; finulus.
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SF alternative splice product is L-Myc-1 (long form) lacking the whole DNA-binding bHLH-ZIP domain T02385;
SF the short form T02386only comprises the trans-activation domain of L-Myc [2];
SF same DNA-binding specificity as c-Myc [2];
SF interacts with Max through the bHLH-ZIP domain [2];
SF trans-activating domain within the N-terminal part [2];
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FF reduced trans-activation and transformation capability (1-10%) compared with c-Myc [2] [4];
FF gene amplification causes small-cell lung carcinoma [5];
FF expression controlled by transcriptional attenuation [3];
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IN T00489 Max-isoform2; human, Homo sapiens.
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DR TRANSPATH: MO000026375.
DR EMBL: M19720;
DR EMBL: X07262;
DR EMBL: X07263;
DR UniProtKB: P12524-1;
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RN [1]; RE0002653.
RX PUBMED: 2006410.
RA Blackwood E. M., Eisenman R. N.
RT Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc
RL Science 251:1211-1217 (1991).
RN [2]; RE0003207.
RX PUBMED: 1620120.
RA Barrett J., Birrer M. J., Kato G. J., Dosaka-Akita H., Dang C. V.
RT Activation domains of L-Myc and c-Myc determine their transforming potencies in rat embryo cells
RL Mol. Cell. Biol. 12:3130-3137 (1992).
RN [3]; RE0003380.
RX PUBMED: 2850489.
RA Krystal G., Birrer M., Way J., Nau M., Sausville E., Thompson C., Minna J., Battey J.
RT Multiple mechanisms for transcriptional regulation of the myc gene family in small-cell lung cancer
RL Mol. Cell. Biol. 8:3373-3381 (1988).
RN [4]; RE0003382.
RX PUBMED: 2457153.
RA Birrer M. J., Segal S., DeGreve J. S., Kaye F., Sausville E. A., Minna J. D.
RT L-myc cooperates with ras to transform primary rat embryo fibroblasts
RL Mol. Cell. Biol. 8:2668-2673 (1988).
RN [5]; RE0003383.
RX PUBMED: 1312669.
RA Sekido Y., Takahashi T., Makela T. P., Obata Y., Ueda R., Hida T., Hibi K., Shimokata K., Alitalo K., Takahashi T.
RT Complex intrachromosomal rearrangement in the process of amplification of the L-myc gene in small-cell lung cancer
RL Mol. Cell. Biol. 12:1747-1754 (1992).
RN [6]; RE0003449.
RX PUBMED: 2997622.
RA Nau M. M., Brooks B. J., Battey J., Sausville E., Gazdar A. F., Kirsch I. R., McBride O. W., Bertness V., Hollis G. F., Minna J. D.
RT L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer
RL Nature 318:69-73 (1985).
RN [7]; RE0006778.
RX PUBMED: 3322939.
RA DePinho R. A., Hatton K. S., Tesfaye A., Yancopoulos G. D., Alt F. W.
RT The human myc gene family: structure and activity of L-myc and an L-myc pseudogene
RL Genes Dev. 1:1311-1326 (1987).
RN [8]; RE0006779.
RX PUBMED: 2827002.
RA Kaye F., Battey J., Nau M., Brooks B., Seifter E., de Greve J., Birrer M., Sausville E., Minna J.
RT Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing
RL Mol. Cell. Biol. 8:186-195 (1988).
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