AC T02387
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ID T02387
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DT 07.04.1998 (created); ewi.
DT 07.06.2006 (updated); jag.
CO Copyright (C), QIAGEN.
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FA L-Myc1
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SY L-Myc proto-oncogene protein 1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006366 Mycl.
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CL C0012; bHLH-ZIP; 1.2.6.5.3.
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CP (embryo:) kidney, lung, brain, neural tube [4].
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FF forced L-Myc expression in lens fiber cells leads to perturbation of differentiation [3];
FF homozygous null L-myc mice do not show phenotypic abnormalities [4];
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IN T00489 Max-isoform2; human, Homo sapiens.
IN T09085 Max; Mammalia.
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DR TRANSPATH: MO000026377.
DR UniProtKB: P10166;
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RN [1]; RE0003351.
RX PUBMED: 1644290.
RA Mukherjee B., Morgenbesser S. D., DePinho R. A.
RT Myc family oncoproteins function through a common pathway to transform normal cells in culture: cross-interference by Max and trans-acting dominant mutants
RL Genes Dev. 6:1480-1492 (1992).
RN [2]; RE0006780.
RX PUBMED: 2828024.
RA Legouy E., DePinho R., Zimmerman K., Collum R., Yancopoulos G., Mitsock L., Kriz R., Alt F. W.
RT Structure and expression of the murine L-myc gene
RL EMBO J. 6:3359-3366 (1987).
RN [3]; RE0006781.
RX PUBMED: 7882978.
RA Morgenbesser S. D., Schreiber-Agus N., Bidder M., Mahon K. A., Overbeek P. A., Horner J., DePinho R. A.
RT Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo
RL EMBO J. 14:743-756 (1995).
RN [4]; RE0006782.
RX PUBMED: 8657155.
RA Hatton K. S., Mahon K., Chin L., Chiu F.-C., Lee H.-W., Peng D., Morgenbesser S. D., Horner J., DePinho R. A.
RT Expression and activity of L-Myc in normal mouse development
RL Mol. Cell. Biol. 16:1794-1804 (1996).
RN [5]; RE0006786.
RX PUBMED: 8521822.
RA Hurlin P. J., Queva C., Koskinen P. J., Steingrimsson E., Ayer D. E., Copeland N. G., Jenkins N. A., Eisenman R. N.
RT Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation
RL EMBO J. 14:5646-5659 (1995).
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