AC T01564
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ID T01564
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DT 19.09.1995 (created); ewi.
DT 08.07.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA Mxi1
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SY MAD2; MAX interacting protein 1; Max interactor 1; MAXD2; MXD2; MXI1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004679 MXI1; HGNC: MXI1.
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CL C0012; bHLH-ZIP; 1.2.6.7.5.
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SF similar to Mad;
SF does not bind to DNA by itself, but forms a DNA-binding complex with Max;
SF acidic region: no functional transcription activating region;
SF revised sequence;
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CP widespread; highest levels in heart, brain, lung; lower in liver, kidney, skeletal muscle; very low in placenta, pancreas.
EX brain,,,adult; detectable; Northern blot; RNA (undefined); [2].
EX heart,,,adult; detectable; Northern blot; RNA (undefined); [2].
EX kidney (right and left),,,adult; detectable; Northern blot; RNA (undefined); [2].
EX liver,,,adult; detectable; Northern blot; RNA (undefined); [2].
EX lung (right and left),,,adult; detectable; Northern blot; RNA (undefined); [2].
EX muscles,,,adult; detectable; Northern blot; RNA (undefined); [2].
EX pancreas,,,adult; detectable; Northern blot; RNA (undefined); [2].
EX placenta,,,adult; detectable; Northern blot; RNA (undefined); [2].
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FF transcriptionally inert;
FF complex with Max: represses c-Myc and N-Myc effects by competition;
FF 20-fold induction upon differentiation (U937 cells);
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IN T01567 Max-isoform1; human, Homo sapiens.
IN T00489 Max-isoform2; human, Homo sapiens.
IN T05056 Max; human, Homo sapiens.
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MX M01034 V$EBOX_Q6_01.
MX M04724 V$MXI1_01.
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DR TRANSPATH: MO000025769.
DR UniProtKB: P50539;
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RN [1]; RE0003363.
RX PUBMED: 8202517.
RA Lahoz E. G., Xu L., Schreiber-Agus N., DePinho R. A.
RT Suppression of Myc, but not E1a, transformation activity by Max-associated proteins, Mad and Mxi1
RL Proc. Natl. Acad. Sci. USA 91:5503-5507 (1994).
RN [2]; RE0003402.
RX PUBMED: 8425219.
RA Zervos A. S., Gyuris J., Brent R.
RT Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites
RL Cell 72:223-232 (1993).
RN [3]; RE0050488.
RX PUBMED: 15121849.
RA Grinberg A. V., Hu C. D., Kerppola T. K.
RT Visualization of Myc/Max/Mad family dimers and the competition for dimerization in living cells.
RL Mol. Cell. Biol. 24:4294-4308 (2004).
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