TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01564 XX ID T01564 XX DT 19.09.1995 (created); ewi. DT 08.07.2014 (updated); yre. CO Copyright (C), QIAGEN. XX FA Mxi1 XX SY MAD2; MAX interacting protein 1; Max interactor 1; MAXD2; MXD2; MXI1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004679 MXI1; HGNC: MXI1. XX CL C0012; bHLH-ZIP; XX SF similar to Mad; SF does not bind to DNA by itself, but forms a DNA-binding complex with Max; SF acidic region: no functional transcription activating region; SF revised sequence; XX CP widespread; highest levels in heart, brain, lung; lower in liver, kidney, skeletal muscle; very low in placenta, pancreas. EX brain,,,adult; detectable; Northern blot; RNA (undefined); [2]. EX heart,,,adult; detectable; Northern blot; RNA (undefined); [2]. EX kidney (right and left),,,adult; detectable; Northern blot; RNA (undefined); [2]. EX liver,,,adult; detectable; Northern blot; RNA (undefined); [2]. EX lung (right and left),,,adult; detectable; Northern blot; RNA (undefined); [2]. EX muscles,,,adult; detectable; Northern blot; RNA (undefined); [2]. EX pancreas,,,adult; detectable; Northern blot; RNA (undefined); [2]. EX placenta,,,adult; detectable; Northern blot; RNA (undefined); [2]. XX FF transcriptionally inert; FF complex with Max: represses c-Myc and N-Myc effects by competition; FF 20-fold induction upon differentiation (U937 cells); XX IN T01567 Max-isoform1; human, Homo sapiens. IN T00489 Max-isoform2; human, Homo sapiens. IN T05056 Max; human, Homo sapiens. XX MX M01034 V$EBOX_Q6_01. MX M04724 V$MXI1_01. XX DR TRANSPATH: MO000025769. DR UniProtKB: P50539; XX RN [1]; RE0003363. RX PUBMED: 8202517. RA Lahoz E. G., Xu L., Schreiber-Agus N., DePinho R. A. RT Suppression of Myc, but not E1a, transformation activity by Max-associated proteins, Mad and Mxi1 RL Proc. Natl. Acad. Sci. USA 91:5503-5507 (1994). RN [2]; RE0003402. RX PUBMED: 8425219. RA Zervos A. S., Gyuris J., Brent R. RT Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites RL Cell 72:223-232 (1993). RN [3]; RE0050488. RX PUBMED: 15121849. RA Grinberg A. V., Hu C. D., Kerppola T. K. RT Visualization of Myc/Max/Mad family dimers and the competition for dimerization in living cells. RL Mol. Cell. Biol. 24:4294-4308 (2004). XX //