TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T04351 XX ID T04351 XX DT 22.02.2001 (created); rio. DT 18.10.2012 (updated); spk. CO Copyright (C), QIAGEN. XX FA TBX2 XX SY T-box protein 2. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G002675 TBX2; HGNC: TBX2. XX CL C0044; T-box; XX SF forms together with TBX4 T04349 a chromosomal cluster [1]; SF R122-A122 exchange destroys DNA binding activity [3]; SF binds as monomer while the T-box family members Brachyury and TBX1 T04352T04354 bind as dimer [3]; XX FF repressor of basal transcription [2] [4]; FF in this repression mechanism Nkx2.5 T01675 functions as a cardiac accessory factor for Tbx2, which in turn represses the ANF promoter in the atrioventricular canal [4]; XX IN T06377 PML; human, Homo sapiens. XX MX M08900 V$TBX2RELATED_Q6. MX M04134 V$TBX2_02. MX M05365 V$TBX2_03. MX M03889 V$TBX2_Q2. MX M08831 V$TBX2_Q5. XX DR TRANSPATH: MO000028209. DR UniProtKB: Q13207; XX RN [1]; RE0015793. RX PUBMED: 10945475. RA Yi C. H., Russ A., Brook J. D. RT Virtual cloning and physical mapping of a human T-box gene, TBX4 RL Genomics 67:92-95 (2000). RN [2]; RE0016014. RX PUBMED: 10468588. RA He M. l., Wen L., Campbell C. E., Wu J. Y., Rao Y. RT Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome RL Proc. Natl. Acad. Sci. USA 96:10212-10217 (1999). RN [3]; RE0016866. RX PUBMED: 11111039. RA Sinha S., Abraham S., Gronostajski R. M., Campbell C. E. RT Differential DNA binding and transcription modulation by three T-box proteins, T, TBX1 and TBX2 RL Gene 258:15-29 (2000). RN [4]; RE0025079. RX PUBMED: 12023302. RA Habets P. E., Moorman A. F., Clout D. E., van Roon M. A., Lingbeek M., van Lohuizen M., Campione M., Christoffels V. M. RT Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation. RL Genes Dev. 16:1234-1246 (2002). RN [5]; RE0053128. RX PUBMED: 18025091. RA Abrahams A., Mowla S., Parker M. I., Goding C. R., Prince S. RT UV-mediated regulation of the anti-senescence factor Tbx2. RL J. Biol. Chem. 283:2223-2230 (2008). XX //