AC T00221
XX
ID T00221
XX
DT 15.10.1992 (created); ewi.
DT 14.12.2009 (updated); sla.
CO Copyright (C), QIAGEN.
XX
FA E2F:DP
XX
SY E2F; EIIF.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
HO EIIaE-A.
XX
CL C0023; fork head.
XX
SF DNA binding activity, E2F is generally composed of an E2F-family member (E2F-1, -2, -3, -4) and DP-1 (or a related protein) in a heterodimeric complex;
SF prior to crystal structure belongs to bHLH-zip factors [27];
XX
CP (HeLa).
XX
FF activator of myc (basal + E1A-induced activation);
FF important for p107 promoter activity [24];
XX
IN T01487 cyclinA; human, Homo sapiens.
IN T01377 E2F-BF; mouse, Mus musculus.
IN T01378 E2F-I; mouse, Mus musculus.
IN T00206 E4; adenovirus type 5.
IN T01301 E4; adenovirus type 2.
IN T01486 p107; human, Homo sapiens.
IN T00722 pRb; human, Homo sapiens.
XX
MX M00024 V$E2F_01.
MX M00050 V$E2F_02.
MX M00516 V$E2F_03.
MX M00803 V$E2F_Q2.
MX M00425 V$E2F_Q3.
MX M00918 V$E2F_Q3_01.
MX M00426 V$E2F_Q4.
MX M00919 V$E2F_Q4_01.
MX M00939 V$E2F_Q4_02.
MX M00427 V$E2F_Q6.
MX M00920 V$E2F_Q6_01.
XX
BS R00326.
BS R00329.
BS R00330.
BS R03879.
BS R00310.
BS R00311.
BS R02141.
BS R04539.
BS R04555.
BS R01801.
BS R09550.
BS R09551.
BS R11777.
BS R09600.
BS R09601.
BS R08811.
BS R08803.
BS R08804.
BS R08805.
BS R08806.
BS R08807.
BS R08808.
BS R01851.
BS R01852.
BS R08798.
BS R08799.
BS R08507.
BS R08508.
BS R08663.
BS R08817.
BS R09584.
BS R08900.
XX
DR TRANSPATH: MO000024781.
DR TRANSCOMPEL: C00193.
XX
RN [1]; RE0000162.
RX PUBMED: 2143697.
RA Bagchi S., Raychaudhuri P., Nevins J. R.
RT Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: a novel mechanism for E1A trans-activation
RL Cell 62:659-669 (1990).
RN [2]; RE0000163.
RX PUBMED: 1828392.
RA Chellappan S. P., Hiebert S., Mudryj M., Horowitz J. M., Nevins J. R.
RT The E2F transcription factor is a cellular target for the RB protein
RL Cell 65:1053-1061 (1991).
RN [3]; RE0000164.
RX PUBMED: 1829647.
RA Mudryj M., Devoto S. H., Hiebert S. W., Hunter T., Pines J., Nevins J. R.
RT Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A
RL Cell 65:1243-1253 (1991).
RN [4]; RE0000165.
RX PUBMED: 1828393.
RA Bagchi S., Weinmann R., Raychaudhuri P.
RT The retinoblastoma protein copurifies with E2F-I; an E1A-regulated inhibitor of the transcription factor E2F
RL Cell 65:1063-1072 (1991).
RN [5]; RE0000333.
RX PUBMED: 2820719.
RA Yee A. S., Reichel R., Kovesdi I., Nevins J. R.
RT Promoter interaction of the E1A-inducible factor E2F and its potential role in the formation of a multi-component complex
RL EMBO J. 6:2061-2068 (1987).
RN [6]; RE0000440.
RX PUBMED: 2531078.
RA Jansen-Duerr P., Boeuf H., Kedinger C.
RT Cooperative binding of two E2F molecules to an E1a-responsive promoter is triggered by the adenovirus E1a, but not by a cellular E1a-like activity
RL EMBO J. 8:3365-3370 (1989).
RN [7]; RE0000625.
RX PUBMED: 2532611.
RA Huang M.-M., Hering P.
RT The adenovirus early 4 open reading frame 6/7 protein regulates the DNA binding activity of the cellular transcription factor, E2F, through a direct complex
RL Genes Dev. 3:1699-1710 (1989).
RN [8]; RE0000640.
RX PUBMED: 2550320.
RA Hardy S., Engel D. A., Shenk T.
RT An adenovirus early region 4 gene product is required for induction of the infection-specific form of cellular E2F activity
RL Genes Dev. 3:1062-1074 (1989).
RN [9]; RE0000657.
RX PUBMED: 2721961.
RA Thalmeier K., Synovzik H., Mertz R., Winnacker E.-L., Lipp M.
RT Nuclear factor E2F mediates basic transcription and trans-activation by E1a of the human MYC promoter
RL Genes Dev. 3:527-536 (1989).
RN [10]; RE0000829.
RX PUBMED: 2522934.
RA Loeken M. R., Brady J.
RT The Adenovirus EIIA Enhancer
RL J. Biol. Chem. 264:6572-6579 (1989).
RN [11]; RE0001158.
RX PUBMED: 1832724.
RA Neill S. D., Nevins J. R.
RT Genetic analysis of the adenovirus E4 6/7 trans activator: interaction with E2F and induction of a stable DNA-protein complex are critical for activity
RL J. Virol. 65:5364-5373 (1991).
RN [12]; RE0001235.
RX PUBMED: 2960885.
RA Jalinot P., Devaux B., Kedinger C.
RT The Abundance and In Vitro DNA Binding of Three Cellular Proteins Interacting with the Adenovirus EIIa Early Promoter Are Not Modified by the EIa Gene Products
RL Mol. Cell. Biol. 7:3806-3817 (1987).
RN [13]; RE0001236.
RX PUBMED: 2523514.
RA Yee A. S., Raychaudhuri P., Jakoi L., Nevins J. R.
RT The Adenovirus-Inducible Factor E2F Stimulates Transcription after Specific DNA Binding
RL Mol. Cell. Biol. 9:578-585 (1989).
RN [14]; RE0001391.
RX PUBMED: 2601705.
RA Blake M. C., Azizkhan J. C.
RT Transcription Factor E2F Is Required for Efficient Expression of the Hamster Dihydrofolate Reductase Gene In Vitro and In Vivo
RL Mol. Cell. Biol. 9:4994-5002 (1989).
RN [15]; RE0001402.
RX PUBMED: 2531279.
RA Hardy S., Shenk T.
RT E2F from Adenovirus-Infected Cells Binds Cooperatively to DNA Containing Two Properly Oriented and Spaced Recognition Sites
RL Mol. Cell. Biol. 9:4495-4506 (1989).
RN [16]; RE0002277.
RX PUBMED: 2951737.
RA Kovesdi I., Reichel R., Nevins J. R.
RT Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control
RL Proc. Natl. Acad. Sci. USA 84:2180-2184 (1987).
RN [17]; RE0002279.
RX PUBMED: 3476933.
RA SivaRaman L., Thimmappaya B.
RT Two promoter-specific host factors interact with adjacent sequences in an EIA-inducible adenovirus promoter
RL Proc. Natl. Acad. Sci. USA 84:6112-6116 (1987).
RN [18]; RE0002280.
RX PUBMED: 2965812.
RA Jalinot P., Wintzerith M., Gaire M., Hauss C., Egly J. M., Kedinger C.
RT Purification and functional characterization of a cellular transcription factor that binds to an enhancer element within the adenovirus early EIIa promoter
RL Proc. Natl. Acad. Sci. USA 85:2484-2488 (1988).
RN [19]; RE0002386.
RX PUBMED: 2137928.
RA Boeuf H., Reimund B., Jansen-Duerr P., Kedinger C.
RT Differential activation of the E2F transcription factor by the adenovirus EIa and EIV products in F9 cells
RL Proc. Natl. Acad. Sci. USA 87:1782-1786 (1990).
RN [20]; RE0002387.
RX PUBMED: 2137929.
RA Neill S. D., Hemstrom C., Virtanen A., Nevins J. R.
RT An adenovirus E4 gene product trans-activates E2 transcription and stimulates stable E2F binding through a direct association with E2F
RL Proc. Natl. Acad. Sci. USA 87:2008-2012 (1990).
RN [21]; RE0002395.
RX PUBMED: 2524830.
RA Hiebert S. W., Lipp M., Nevins J. R.
RT E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor
RL Proc. Natl. Acad. Sci. USA 86:3594-3598 (1989).
RN [22]; RE0002739.
RX PUBMED: 2141565.
RA Mudryj M., Hiebert S. W., Nevins J. R.
RT A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway
RL EMBO J. 9:2179-2184 (1990).
RN [23]; RE0002921.
RX PUBMED: 1411535.
RA Nevins R.
RT E2F: A link between the Rb tumor suppressor protein and viral oncoproteins
RL Science 258:424-429 (1992).
RN [24]; RE0010545.
RX PUBMED: 7791762.
RA Zhu L., Zhu L., Xie E., Chang L.-S.
RT Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins
RL Mol. Cell. Biol. 15:3552-3562 (1995).
RN [25]; RE0014304.
RX PUBMED: 8621559.
RA Brooks A. R., Shiffman D., Chan C. S., Brooks E. E., Milner P. G.
RT Functional analysis of the human cyclin D2 and cyclin D3 promoters.
RL J. Biol. Chem. 271:9090-9099 (1996).
RN [26]; RE0014321.
RX PUBMED: 8990175.
RA Williams R. S., Shohet R. V., Stillman B.
RT A human protein related to yeast Cdc6p
RL Proc. Natl. Acad. Sci. USA 94:142-147 (1997).
RN [27]; RE0015322.
RX PUBMED: 10090723.
RA Zheng N., Fraenkel E., Pabo C. O., Pavletich N. P.
RT Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP
RL Genes Dev. 13:666-674 (1999).
RN [28]; RE0015801.
RX PUBMED: 9529602.
RA Helin K.
RT Regulation of cell proliferation by the E2F transcription factors
RL Curr. Opin. Gen. Dev. 8:28-35 (1998).
RN [29]; RE0016526.
RX PUBMED: 11491305.
RA Kel A., Kel-Margoulis O., Farnham P., Bartley S., Wingender E., Zhang M.
RT Computer-assisted identification of cell cycle-related genes: new targets for E2F transcription factors
RL J. Mol. Biol. 309:99-120 (2001).
XX
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