AC T02064
AS T22694.
XX
ID T02064
XX
DT 28.01.1997 (created); ewi.
DT 06.02.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA Lab
XX
SY CG1264; F24; F90-2; Homeotic protein labial; labial.
XX
OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
XX
GE G009034 lab.
XX
HO HOXA1 (vert.) T01695,T01696,T01697,T03598.
XX
CL C0006; homeo.
XX
SZ 635 AA; 68.2 kDa (gene) (calc.).
XX
SQ MMDVSSMYGNHPHHHHPHANAYDGYSTTTASAANASSYFAPQQHQPHLQLQQQQQHQHLQ
SQ QPQQHLTYNGYESSSPGNYYPQQQAQLTPPPTSSHQVVQQHQQQQQAQQQQLYPHSHLFS
SQ PSAAEYGITTSTTTGNPGKPLHPSSHSPADSYYESDSVHSYYATAAVATVAPPSNSSPIT
SQ AANASATSNTQQQQQQAAIISSENGMMYTNLDCMYPTAQAQAPVHGYAGQIEEKYAAVLH
SQ ASYAPGMVLEDQDPMMQQATQSQMWHHQQHLAGSYALDAMDSLGMHAHMHHGLPHGHLGN
SQ LANNPHQQQPQVQQQQQQPHQQPQHPQNQSPAAHQQHHQNSVSPNGGMNRQQRGGVISPG
SQ SSTSSSTSASNGAHPASTQSKSPNHSSSIPTYKWMQLKRNVPKPQAPSYLPAPKLPASGI
SQ ASMHDYQMNGQLDMCRGGGGGGSDVGSGPVGVGGNGSPGIGGVLSVQNSLIMANSAAAAG
SQ SAHPNGMGVGLGSGSGLSSCSLSSNTNNSGRTNFTNKQLTELEKEFHFNRYLTRARRIEI
SQ ANTLQLNETQVKIWFQNRRMKQKKRVKEGLIPADILTQHSTSVISEKPPQQQQPQPPELQ
SQ LKSQGSDLGGNELATGAPSTPTTAMTLTAPTSKQS
XX
SC Swiss-Prot#P10105-1
XX
FT 194 588 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 505 565 
PS50071; HOMEOBOX_2.
FT 507 569 
SM00389; HOX_1.
FT 508 564 
PF00046; Homeobox domain.
XX
FF important for endodermal development and required for development of some ectodermal structures (head) [6] [7];
FF expressed at low levels in midgut primordia [3];
FF large raising after fusion and concentrating in the nuclei of a distinct band in the newly formed midgut epithelium [4] [5];
XX
MX M02348 I$LAB_01.
MX M07803 I$LAB_02.
XX
BS R09578.
BS R02507.
XX
DR TRANSPATH: MO000026133.
DR UniProtKB: P10105-1;
DR FLYBASE: FBgn0002522.
XX
RN [1]; RE0005129.
RX PUBMED: 2461299.
RA Mlodzik M., Fjose A., Gehring W. J.
RT Molecular structure and spatial expression of a homeobox gene from the labial region of the antennapedia-complex
RL EMBO J. 7:2569-2578 (1988).
RN [2]; RE0005130.
RX PUBMED: 3014511.
RA Hoey T., Doyle H. J., Harding K., Wedeen C., Levine M.
RT Homeo box gene expression in anterior and posterior regions of the Drosophila embryo
RL Proc. Natl. Acad. Sci. USA 83:4809-4813 (1986).
RN [3]; RE0005131.
RX PUBMED: 2566560.
RA Diederich R. J., Merrill V. K. L., Pultz M. A., Kaufman T. C.
RT Isolation, structure, and expression of labial, a homeotic gene of the antennapedia complex involved in Drosophila head development
RL Genes Dev. 3:399-414 (1989).
RN [4]; RE0005375.
RX PUBMED: 1973634.
RA Immerglueck K., Lawrence P. A., Bienz M.
RT Induction across germ layers in Drosophila mediated by a genetic cascade
RL Cell 62:261-268 (1990).
RN [5]; RE0005376.
RX PUBMED: 1363088.
RA Tremml G., Bienz M.
RT Induction of labial expression in the Drosophila endoderm: response elements for dpp signalling and for autoregulation
RL Development 116:447-456 (1992).
RN [6]; RE0005377.
RX PUBMED: 1687459.
RA Chouinard S., Kaufman T. C.
RT Control of expression of the homeotic labial (lab) locus of Drosophila melanogaster: evidence for both positive and negative autogenous regulation
RL Development 113:1267-1280 (1991).
RN [7]; RE0005378.
RX PUBMED: 2570723.
RA Merrill V. K., Diederich R. J., Turner F. R., Kaufman T. C.
RT A genetic and developmental analysis of mutations in labial, a gene necessary for proper head formation in Drosophila melanogaster
RL Dev. Biol. 135:376-391 (1989).
RN [8]; RE0015328.
RX PUBMED: 7902124.
RA Kalionis B., O'Farrell P. H.
RT A universal target sequence is bound in vitro by diverse homeodomains
RL Mech. Dev. 43:57-70 (1993).
XX
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