AC T03598
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ID T03598
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DT 18.07.2000 (created); rio.
CO Copyright (C), QIAGEN.
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FA HOXA1a
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OS zebra fish, Brachydanio rerio
OC eukaryota; animalia; metazoa; chordata; vertebrata; osteichthyes; actinopterygii; cypriniformes; cyprinoidei; cyprinidae
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HO Lab (Drosophila) T02064.
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CL C0006; homeo.
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SZ 308 AA; 34.6 kDa (cDNA) (calc.).
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SQ MNSYLDYTIYNRGSNTYSSKVGCFPVEQEYLPSACASTNSYIPEGRPVGGNTFTSAPHET
SQ HGTSYAQIQSQAFHLNVDMGKTGHSNFCKQTRPPHSDYGHQHVLTQADDHMRLQSPGFSV
SQ VNMGANIGTYSESNCRPGSVSASHYQSYAYGEPEPHGCGSFSKYQVSPDSDSDSKTNIKQ
SQ APTFDWMKVKRNPPKTVKVAEYGIHGQQNIIRTNFTTKQLTELEKEFHFNKYLTRARRVE
SQ VAATLELNETQVKIWFQNRRMKQKKREKEGTAPVIKRVTLCSSGQNRRPLKLAHRLVPSP
SQ TSDSSTAI
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SC translated from EMBL #U40995
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FT 206 266 
PS50071; HOMEOBOX_2.
FT 208 270 
SM00389; HOX_1.
FT 209 265 
PF00046; Homeobox domain.
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SF treatment with retinoic acid (RA) causes upregulation of HOXA1 [1];
SF overexpression causes abnormal development of the anterior hindbrain, duplication of Mauthner neurons in rhombomere 2 (r2) and fate changes of r2 mesenchymal and neurogenic neural crest [1];
SF probably early duplication events led to 7 HOX clusters in zebrafish instead of 4 in mammals, they were named Aa, Ab, Ba, Bb, Ca, Cb and D [2];
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CP (gastrula stage:) shield at the dorsal surface, (tailbud stage:) stripe on the dorsal surface, (embryo 10-16h:) rhombomere 4, rhombomere 3/4 boundary [1].
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FF involved in the control of anterior hindbrain patterning [1];
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DR TRANSPATH: MO000027531.
DR EMBL: U40995;
DR UniProtKB: Q90423;
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RN [1]; RE0014844.
RX PUBMED: 8631251.
RA Alexandre D., Clarke J. D., Oxtoby E., Yan Y. L., Jowett T., Holder N.
RT Ectopic expression of Hoxa-1 in the zebrafish alters the fate of the mandibular arch neural crest and phenocopies a retinoic acid-induced phenotype
RL Development 122:735-746 (1996).
RN [2]; RE0014862.
RX PUBMED: 9831563.
RA Amores A., Force A., Yan Y. L., Joly L., Amemiya C., Fritz A., Ho R. K., Langeland J., Prince V., Wang Y. L., Westerfield M., Ekker M., Postlethwait J. H.
RT Zebrafish hox clusters and vertebrate genome evolution
RL Science 282:1711-1714 (1998).
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