AC T04995
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ID T04995
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DT 03.12.2001 (created); mas.
DT 06.02.2015 (updated); ros.
CO Copyright (C), QIAGEN.
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FA ZBP99
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SY GC-box-binding zinc finger protein 1; GZP1; transcription factor ZBP-99; zinc finger DNA-binding protein 99; zinc finger protein 281; ZNF281.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002929 ZNF281; HGNC: ZNF281.
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CL C0001; CH; 2.3.3.13.2.
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SF high sequence similarity to T04996 [2];
SF transcript detected in expression analysis (Northern-Blot) is 2.5 kb shorter than expected which is probably due to lack of 2.5 kb of 5�-UTR [1];
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EX blood,basophil granulocyte,Circulatory System & Hematopoietic System,adult; high; Northern blot; mRNA (poly-A); [1].
EX blood,eosinophil granulocyte,Circulatory System & Hematopoietic System,adult; high; Northern blot; mRNA (poly-A); [1].
EX blood,lymphocyte,Circulatory System & Hematopoietic System,adult; high; Northern blot; mRNA (poly-A); [1].
EX blood,lymphocyte,Circulatory System & Hematopoietic System,adult; very high; Northern blot; mRNA (poly-A); [1].
EX blood,monocyte,Circulatory System & Hematopoietic System,adult; high; Northern blot; mRNA (poly-A); [1].
EX blood,neutrophil granulocyte,Circulatory System & Hematopoietic System,adult; high; Northern blot; mRNA (poly-A); [1].
EX brain,,,adult; low; Northern blot; mRNA (poly-A); [1].
EX brain,,,adult; medium; Northern blot; mRNA (poly-A); [1].
EX brain,,,fetal; low; Northern blot; mRNA (poly-A); [1].
EX brain,,,fetal; medium; Northern blot; mRNA (poly-A); [1].
EX colon,,,adult; low; Northern blot; mRNA (poly-A); [1].
EX colon,,,adult; very low; Northern blot; mRNA (poly-A); [1].
EX heart,,,adult; low; Northern blot; mRNA (poly-A); [1].
EX heart,,,adult; medium; Northern blot; mRNA (poly-A); [1].
EX kidney (right and left),,,adult; high; Northern blot; mRNA (poly-A); [1].
EX kidney (right and left),,,adult; medium; Northern blot; mRNA (poly-A); [1].
EX kidney (right and left),,,adult; very high; Northern blot; mRNA (poly-A); [1].
EX kidney (right and left),,,fetal; low; Northern blot; mRNA (poly-A); [1].
EX liver,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX liver,,,adult; very high; Northern blot; mRNA (poly-A); [1].
EX liver,,,fetal; low; Northern blot; mRNA (poly-A); [1].
EX liver,,,fetal; medium; Northern blot; mRNA (poly-A); [1].
EX lung (right and left),,,adult; medium; Northern blot; mRNA (poly-A); [1].
EX lung (right and left),,,fetal; high; Northern blot; mRNA (poly-A); [1].
EX lung (right and left),,,fetal; low; Northern blot; mRNA (poly-A); [1].
EX lung (right and left),,,fetal; medium; Northern blot; mRNA (poly-A); [1].
EX muscles,,,adult; low; Northern blot; mRNA (poly-A); [1].
EX muscles,,,adult; medium; Northern blot; mRNA (poly-A); [1].
EX placenta,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX placenta,,,adult; very high; Northern blot; mRNA (poly-A); [1].
EX small intestine,,,adult; low; Northern blot; mRNA (poly-A); [1].
EX small intestine,,,adult; low; Northern blot; mRNA (poly-A); [1].
EX spleen,,,adult; low; Northern blot; mRNA (poly-A); [1].
EX spleen,,,adult; medium; Northern blot; mRNA (poly-A); [1].
EX thymus,,,adult; low; Northern blot; mRNA (poly-A); [1].
EX thymus,,,adult; medium; Northern blot; mRNA (poly-A); [1].
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FF binds specifically to promoters of ODC (GC-rich box) and gastrin genes [1];
FF represses ODC expression in tissue culture (gastric and colon cells, heterologous reporter gene assays) [1];
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IN T33762 DRIP205; human, Homo sapiens.
IN T05220 Evi-1; human, Homo sapiens.
IN T10210 Evi-1; human, Homo sapiens.
IN T02336 PLZF; human, Homo sapiens.
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MX M01597 V$ZFP281_01.
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BS R18750.
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DR TRANSPATH: MO000028758.
DR UniProtKB: Q9Y2X9;
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RN [1]; RE0017377.
RX PUBMED: 10448078.
RA Law D. J., Du M., Law G. L., Merchant J. L.
RT ZBP-99 defines a conserved family of transcription factors and regulates ornithine decarboxylase gene expression
RL Biochem. Biophys. Res. Commun. 262:113-120 (1999).
RN [2]; RE0017378.
RX PUBMED: 10405178.
RA Lisowsky T., Polosa P. L., Sagliano A., Roberti M., Gadaleta M. N., Cantatore P.
RT Identification of human GC-box-binding zinc finger protein, a new Kruppel-like zinc finger protein, by the yeast one-hybrid screening with a GC-rich target sequence
RL FEBS Lett. 453:369-374 (1999).
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