AC T04996
XX
ID T04996
XX
DT 03.12.2001 (created); mas.
DT 01.12.2011 (updated); hna.
CO Copyright (C), QIAGEN.
XX
FA ZBP89
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SY transcription factor ZBP-89; zinc finger DNA-binding protein 89; zinc finger protein 148; ZNF148.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002930 ZNF148; HGNC: ZNF148.
XX
CL C0001; CH.
XX
SZ 794 AA; 89.0 kDa (calc.).
XX
SQ MNIDDKLEGLFLKCGGIDEMQSSRTMVVMGGVSGQSTVSGELQDSVLQDRSMPHQEILAA
SQ DEVLQESEMRQQDMISHDELMVHEETVKNDEEQMETHERLPQGLQYALNVPISVKQEITF
SQ TDVSEQLMRDKKQIREPVDLQKKKKRKQRSPAKILTINEDGSLGLKTPKSHVCEHCNAAF
SQ RTNYHLQRHVFIHTGEKPFQCSQCDMRFIQKYLLQRHEKIHTGEKPFRCDECGMRFIQKY
SQ HMERHKRTHSGEKPYQCEYCLQYFSRTDRVLKHKRMCHENHDKKLNRCAIKGGLLTSEED
SQ SGFSTSPKDNSLPKKKRQKTEKKSSGMDKESALDKSDLKKDKNDYLPLYSSSTKVKDEYM
SQ VAEYAVEMPHSSVGGSHLEDASGEIHPPKLVLKKINSKRSLKQPLEQNQTISPLSTYEES
SQ KVSKYAFELVDKQALLDSEGNADIDQVDNLQEGPSKPVHSSTNYDDAMQFLKKKRYLQAA
SQ SNNSREYALNVGTIASQPSVTQAAVASVIDESTTASILESQALNVEIKSNHDKNVIPDEV
SQ LQTLLDHYSHKANGQHEISFSVADTEVTSSISINSSEVPEVTPSENVGSSSQASSSDKAN
SQ MLQEYSKFLQQALDRTSQNDAYLNSPSLNFVTDNQTLPNQPAFSSIDKQVYATMPINSFR
SQ SGMNSPLRTTPDKSHFGLIVGDSQHSFPFSGDETNHASATSTQDFLDQVTSQKKAEAQPV
SQ HQAYQMSSFEQPFRAPYHGSRAGIATQFSTANGQVNLRGPGTSAEFSEFPLVNVNDNRAG
SQ MTSSPDATTGQTFG
XX
SC translated from EMBL #AF039019
XX
FT 56 97 
acidic region [2].
FT 73 656 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 131 149 
basic region [2].
FT 171 193 
PF00096; zf-C2H2.
FT 171 193 
SM00355; c2h2final6.
FT 171 198 
PS50157; ZINC_FINGER_C2H2_2.
FT 173 193 
zinc finger [2].
FT 199 221 
PF00096; zf-C2H2.
FT 199 221 
SM00355; c2h2final6.
FT 199 226 
PS50157; ZINC_FINGER_C2H2_2.
FT 201 214 zinc finger [2].
FT 227 249 PF00096; zf-C2H2.
FT 227 249 SM00355; c2h2final6.
FT 227 254 PS50157; ZINC_FINGER_C2H2_2.
FT 229 249 zinc finger [2].
FT 255 278 PF00096; zf-C2H2.
FT 255 278 SM00355; c2h2final6.
FT 255 283 PS50157; ZINC_FINGER_C2H2_2.
FT 257 278 zinc finger [2].
FT 313 323 basic region [2].
FT 472 475 basic region [2].
XX
SF high sequence similarity to T04995 [2];
SF cDNA sequence almost identical to that of human ht-beta gene except for a single-nucleotide deletion in ht-beta which leads to a premature stop codon and a truncated protein with a length of 494 amino acids: the deletion in ht-beta is maybe due to somatic mutation [3];
SF interestingly ht-beta acts as transcriptional activator (on T-cell receptor gene, EGF-induced) [1];
SF while ht-beta acts as transcriptional repressor in many contexts [1] [4] [5] [6] [7] [8];
XX
FF binds to G/C-rich elements and mediates p53-independent apoptosis [9];
FF binds GC-rich region of promoters [4];
FF controls expression of the gene for rat gastrin, mouse BFCOL1 type 1collagen, human beta-enolase, and human ornithine decarboxylase (ODC) [3] [6] [7] [8];
FF enhances human stromelysin promoter activity [4];
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MX M00721 V$CACCCBINDINGFACTOR_Q6.
MX M01816 V$ZBP89_Q4.
MX M07397 V$ZBP89_Q4_01.
XX
BS R19122.
BS R19124.
BS R19125.
BS R11771.
BS R37333.
BS R37335.
BS R19135.
BS R20713.
BS R31980.
BS R19120.
XX
DR TRANSPATH: MO000028759.
DR EMBL: AF039019;
DR EMBL: AJ236885;
DR EMBL: U96633;
DR UniProtKB: Q9UQR1;
XX
RN [1]; RE0002925.
RX PUBMED: 8355710.
RA Wang Y., Kobori J. K., Hood L.
RT The ht beta gene encodes a novel CACCC box-binding protein that regulates T-cell receptor gene expression
RL Mol. Cell. Biol. 13:5691-5701 (1993).
RN [2]; RE0017378.
RX PUBMED: 10405178.
RA Lisowsky T., Polosa P. L., Sagliano A., Roberti M., Gadaleta M. N., Cantatore P.
RT Identification of human GC-box-binding zinc finger protein, a new Kruppel-like zinc finger protein, by the yeast one-hybrid screening with a GC-rich target sequence
RL FEBS Lett. 453:369-374 (1999).
RN [3]; RE0017379.
RX PUBMED: 9457682.
RA Law D. J., Tarle S. A., Merchant J. L.
RT The human ZBP-89 homolog, located at chromosome 3q21, represses gastrin gene expression
RL Mamm. Genome 9:165-167 (1998).
RN [4]; RE0017380.
RX PUBMED: 10359087.
RA Ye S., Whatling C., Watkins H., Henney A.
RT Human stromelysin gene promoter activity is modulated by transcription factor ZBP-89.
RL FEBS Lett. 450:268-272 (1999).
RN [5]; RE0017385.
RX PUBMED: 8943318.
RA Merchant J. L., Iyer G. R., Taylor B. R., Kitchen J. R., Mortensen E. R., Wang Z., Flintoft R. J., Michel J. B., Bassel-Duby R.
RT ZBP-89, a Kruppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter
RL Mol. Biol. Cell 16:6644-6653 (1996).
RN [6]; RE0017387.
RX PUBMED: 9030551.
RA Hasegawa T., Takeuchi A., Miyaishi O., Isobe K. i., de Crombrugghe B.
RT Cloning and characterization of a transcription factor that binds to the proximal promoters of the two mouse type I collagen genes
RL J. Biol. Chem. 272:4915-4923 (1997).
RN [7]; RE0017388.
RX PUBMED: 9417107.
RA Passantino R., Antona V., Barbieri G., Rubino P., Melchionna R., Cossu G., Feo S., Giallongo A.
RT Negative regulation of beta enolase gene transcription in embryonic muscle is dependent upon a zinc finger factor that binds to the G-rich box within the muscle-specific enhancer.
RL J. Biol. Chem. 273:484-494 (1998).
RN [8]; RE0017389.
RX PUBMED: 9685330.
RA Law G. L., Itoh H., Law D. J., Mize G. J., Merchant J. L., Morris D. R.
RT Transcription factor ZBP-89 regulates the activity of the ornithine decarboxylase promoter
RL J. Biol. Chem. 273:19955-19964 (1998).
RN [9]; RE0030583.
RX PUBMED: 14654702.
RA Bai L., Merchant J. L.
RT Transcription factor ZBP-89 is required for STAT1 constitutive expression.
RL Nucleic Acids Res. 31:7264-70 (2003).
XX
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