AC T10687
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ID T10687
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DT 11.07.2003 (created); cch.
DT 03.05.2013 (updated); yre.
CO Copyright (C), QIAGEN.
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FA huntingtin
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SY HD protein; Hdh; Huntington; Huntington disease gene homolog; Huntington's disease protein homolog.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005622 Htt.
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IN T04687 NCOR1; human, Homo sapiens.
IN T05957 REST; rat, Rattus norvegicus.
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BS R21785.
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DR TRANSPATH: MO000036350.
DR UniProtKB: P51111;
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RN [1]; RE0023030.
RX PUBMED: 10801775.
RA Liu Y. F., Dorow D., Marshall J.
RT Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin.
RL J. Biol. Chem. 275:19035-19040 (2000).
RN [2]; RE0070105.
RX PUBMED: 20026656.
RA Thompson L. M., Aiken C. T., Kaltenbach L. S., Agrawal N., Illes K., Khoshnan A., Martinez-Vincente M., Arrasate M., O'Rourke J. G., Khashwji H., Lukacsovich T., Zhu Y. Z., Lau A. L., Massey A., Hayden M. R., Zeitlin S. O., Finkbeiner S., Green K. N., LaFerla F. M., Bates G., Huang L., Patterson P. H., Lo D. C., Cuervo A. M., Marsh J. L., Steffan J. S.
RT IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.
RL J. Cell Biol. 187:1083-1099 (2009).
RN [3]; RE0070235.
RX PUBMED: 19299482.
RA Huang K., Sanders S., Singaraja R., Orban P., Cijsouw T., Arstikaitis P., Yanai A., Hayden M. R., El-Husseini A.
RT Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity.
RL FASEB J. 23:2605-2615 (2009).
RN [4]; RE0070567.
RX PUBMED: 15911879.
RA Luo S., Vacher C., Davies J. E., Rubinsztein D. C.
RT Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity.
RL J. Cell Biol. 169:647-656 (2005).
RN [5]; RE0071008.
RX PUBMED: 16699508.
RA Yanai A., Huang K., Kang R., Singaraja R. R., Arstikaitis P., Gan L., Orban P. C., Mullard A., Cowan C. M., Raymond L. A., Drisdel R. C., Green W. N., Ravikumar B., Rubinsztein D. C., El-Husseini A., Hayden M. R.
RT Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.
RL Nat. Neurosci. 9:824-831 (2006).
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