AC T00065
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ID T00065
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DT 14.12.1992 (created); ewi.
DT 30.01.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA B-Myb
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SY B-Myb; BMYB; MGC15600; MYBL2; v-myb myeloblastosis viral oncogene homolog (avian)-like 2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003920 MYBL2; HGNC: MYBL2.
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CL C0022; trp; 3.5.1.1.3.
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CP widespread occurrence [3].
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FF transcriptional activator (e. g., of cyclin D1 and cdc2 gene) and repressor, the latter by inhibiting transactivation by other Myb-proteins [3];
FF activation of cell cycle genes in fibroblasts reduces growth factor requirement and induces a transformed phenotype [4];
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IN T17035 LIN-9; human, Homo sapiens.
IN T04687 NCOR1; human, Homo sapiens.
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MX M04048 V$MYBL2_04.
MX M00913 V$MYB_Q5_01.
MX M08890 V$MYB_Q5_02.
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BS R01098.
BS R34614.
BS R34826.
BS R34828.
BS R31136.
BS R31137.
BS R31140.
BS R31141.
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DR TRANSPATH: MO000021901.
DR UniProtKB: P10244;
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RN [1]; RE0000916.
RX PUBMED: 2160970.
RA Mizuguchi G., Nakagoshi H., Nagase T., Nomura N., Date T., Ueno Y., Ishii S.
RT DNA Binding Activity and Transcriptional Activator Function of the Human B-myb Protein Compared with c-MYB
RL J. Biol. Chem. 265:9280-9284 (1990).
RN [2]; RE0003578.
RX PUBMED: 3060855.
RA Nomura N., Takahashi M., Matsui M., Ishii S., Date T., Sasamoto S., Ishizaki R.
RT Isolation of human cDNA clones of myb-related genes, A-myb and B-myb.
RL Nucleic Acids Res. 16:11075-11089 (1988).
RN [3]; RE0003582.
RX PUBMED: 1425593.
RA Foos G., Grimm S., Klempnauer K. H.
RT Functional antagonism between members of the myb family: b-myb inhibits V-myb induced gene activation
RL EMBO J. 11:4619-4629 (1992).
RN [4]; RE0003584.
RX PUBMED: 1438227.
RA Sala A., Calabretta B.
RT Regulation of BALB/c 3T3 fibroblast proliferation by B-myb is accompanied by selective activation of cdc2 and cyclin D1 expression
RL Proc. Natl. Acad. Sci. USA 89:10415-10419 (1992).
RN [5]; RE0032033.
RX PUBMED: 12757710.
RA Iakova P., Awad S. S., Timchenko N. A.
RT Aging reduces proliferative capacities of liver by switching pathways of C/EBPalpha growth arrest.
RL Cell 113:495-506 (2003).
RN [6]; RE0046322.
RX PUBMED: 11997503.
RA Li X., McDonnell D. P.
RT The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT
RL Mol. Cell. Biol. 22:3663-73 (2002).
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