AC T17209
XX
ID T17209
XX
DT 10.03.2005 (created); nvo.
DT 28.01.2015 (updated); spk.
CO Copyright (C), QIAGEN.
XX
FA ERK2
XX
SY Erk-2; MAPK1.
XX
OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
XX
IN T08533 Fra-1; mouse, Mus musculus.
IN T10108 NURR1-isoform1; human, Homo sapiens.
IN T23091 p300; Mammalia.
IN T29721 Pkm2-isoform-M2; human, Homo sapiens.
IN T30232 Pkm2; human, Homo sapiens.
IN T15014 SNA; human, Homo sapiens.
IN T14458 STAT3; Mammalia.
XX
DR TRANSPATH: MO000047522.
XX
RN [1]; RE0018422.
RX PUBMED: 9155017.
RA Waskiewicz A. J., Flynn A. F., Proud C. G., Cooper J. A.
RT Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2
RL EMBO J. 16:1909-1920 (1997).
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RX PUBMED: 8393135.
RA WU J., HARRISON J.K., DENT P., LYNCH K.R., WEBER M.J., STURGILL T.W.
RT Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.
RL Mol. Cell. Biol. 13:4539-4548 (1993).
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RX PUBMED: 1327754.
RA STOKOE D., CAMPBELL D.G., NAKIELNY S., HIDAKA H., LEEVERS S.J., MARSHALL C., COHEN P.
RT MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.
RL EMBO J. 11:3985-3999 (1992).
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RX PUBMED: 10508618.
RA Jones N., Dumont D. J.
RT Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation
RL Curr. Biol. 9:1057-1060 (1999).
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RX PUBMED: 11226259.
RA Luttrell L. M., Roudabush F. L., Choy E. W., Miller W. E., Field M. E., Pierce K. L., Lefkowitz R. J.
RT Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds.
RL Proc. Natl. Acad. Sci. USA 98:2449-2454 (2001).
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RX PUBMED: 10551817.
RA Richard D. E., Berra E., Gothie E., Roux D., Pouyssegur J.
RT p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.
RL J. Biol. Chem. 274:32631-32637 (1999).
RN [7]; RE0023012.
RX PUBMED: 12151396.
RA Maekawa M., Nishida E., Tanoue T.
RT Identification of the Anti-proliferative protein Tob as a MAPK substrate.
RL J. Biol. Chem. 277:37783-37787 (2002).
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RX PUBMED: 11278799.
RA Slack D. N., Seternes O. M., Gabrielsen M., Keyse S. M.
RT Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1.
RL J. Biol. Chem. 276:16491-16500 (2001).
RN [9]; RE0023082.
RX PUBMED: 9788880.
RA Dowd S., Sneddon A. A., Keyse S. M.
RT Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases.
RL J. Cell Sci. 111:3389-3399 (1998).
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RX PUBMED: 12048211.
RA Dwivedi P. P., Hii C. S., Ferrante A., Tan J., Der C. J., Omdahl J. L., Morris H. A., May B. K.
RT Role of MAP kinases in the 1,25-dihydroxyvitamin D3-induced transactivation of the rat cytochrome P450C24 (CYP24) promoter. Specific functions for ERK1/ERK2 and ERK5.
RL J. Biol. Chem. 277:29643-53 (2002).
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RA Kotzka J., Muller-Wieland D., Roth G., Kremer L., Munck M., Schurmann S., Knebel B., Krone W.
RT Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade.
RL J. Lipid Res. 41:99-108 (2000).
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RA Zhang S., Fukushi M., Hashimoto S., Gao C., Huang L., Fukuyo Y., Nakajima T., Amagasa T., Enomoto S., Koike K., Miura O., Yamamoto N., Tsuchida N.
RT A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling.
RL Biochem. Biophys. Res. Commun. 297:17-23 (2002).
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RX PUBMED: 12637547.
RA Baker K. M., Wei G., Schaffner A. E., Ostrowski M. C.
RT Ets-2 and components of mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter.
RL J. Biol. Chem. 278:17876-84 (2003).
RN [14]; RE0030370.
RX PUBMED: 14516797.
RA Schulte G., Fredholm B. B.
RT The G(s)-coupled adenosine A(2B) receptor recruits divergent pathways to regulate ERK1/2 and p38.
RL Exp. Cell Res. 290:168-76 (2003).
RN [15]; RE0030515.
RX PUBMED: 12697810.
RA Sanz-Moreno V., Casar B., Crespo P.
RT p38alpha isoform Mxi2 binds to extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase and regulates its nuclear activity by sustaining its phosphorylation levels.
RL Mol. Cell. Biol. 23:3079-90 (2003).
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RA Eto M., Barandier C., Rathgeb L., Kozai T., Joch H., Yang Z., Luscher T. F.
RT Thrombin suppresses endothelial nitric oxide synthase and upregulates endothelin-converting enzyme-1 expression by distinct pathways: role of Rho/ROCK and mitogen-activated protein kinase.
RL Circ. Res. 89:583-90 (2001).
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RX PUBMED: 9341140.
RA Hocker M., Henihan R. J., Rosewicz S., Riecken E. O., Zhang Z., Koh T. J., Wang T. C.
RT Gastrin and phorbol 12-myristate 13-acetate regulate the human histidine decarboxylase promoter through Raf-dependent activation of extracellular signal-regulated kinase-related signaling pathways in gastric cancer cells.
RL J. Biol. Chem. 272:27015-24 (1997).
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RA Jain N., Zhang T., Fong S. L., Lim C. P., Cao X.
RT Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK).
RL Oncogene 17:3157-67 (1998).
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RA Brummer T., Naegele H., Reth M., Misawa Y.
RT Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf.
RL Oncogene 22:8823-34 (2003).
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RX PUBMED: 9164852.
RA MacKenzie S., Fleming I., Houslay M. D., Anderson N. G., Kilgour E.
RT Growth hormone and phorbol esters require specific protein kinase C isoforms to activate mitogen-activated protein kinases in 3T3-F442A cells.
RL Biochem. J. 324:159-65 (1997).
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RA Purcell N. H., Darwis D., Bueno O. F., Muller J. M., Schule R., Molkentin J. D.
RT Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes.
RL Mol. Cell. Biol. 24:1081-1095 (2004).
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RA Zagar Y., Chaumaz G., Lieberherr M.
RT Signaling cross-talk from Gbeta4 subunit to Elk-1 in the rapid action of androgens
RL J. Biol. Chem. 279:2403-13 (2004).
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RA Kato R., Nonami A., Taketomi T., Wakioka T., Kuroiwa A., Matsuda Y., Yoshimura A.
RT Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation
RL Biochem. Biophys. Res. Commun. 302:767-72 (2003).
RN [24]; RE0038528.
RX PUBMED: 8557638.
RA Singh K., Balligand J. L., Fischer T. A., Smith T. W., Kelly R. A.
RT Regulation of cytokine-inducible nitric oxide synthase in cardiac myocytes and microvascular endothelial cells. Role of extracellular signal-regulated kinases 1 and 2 (ERK1/ERK2) and STAT1 alpha
RL J. Biol. Chem. 271:1111-7 (1996).
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RA Yowe D., Weich N., Prabhudas M., Poisson L., Errada P., Kapeller R., Yu K., Faron L., Shen M., Cleary J., Wilkie T. M., Gutierrez-Ramos C., Hodge M. R.
RT RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes
RL Biochem. J. 359:109-18 (2001).
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RX PUBMED: 12456801.
RA Raychowdhury R., Schafer G., Fleming J., Rosewicz S., Wiedenmann B., Wang T. C., Hocker M.
RT Interaction of early growth response protein 1 (Egr-1), specificity protein 1 (Sp1), and cyclic adenosine 3'5'-monophosphate response element binding protein (CREB) at a proximal response element is critical for gastrin-dependent activation of the chromogranin A promoter
RL Mol. Endocrinol. 16:2802-18 (2002).
RN [27]; RE0038773.
RX PUBMED: 7718484.
RA Topol L. Z., Marx M., Calothy G., Blair D. G.
RT Transformation-resistant mos revertant is unable to activate MAP kinase kinase in response to v-mos or v-raf
RL Cell Growth Differ. 6:27-38 (1995).
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RA Kovalenko D., Yang X., Nadeau R. J., Harkins L. K., Friesel R.
RT Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation
RL J. Biol. Chem. 278:14087-91 (2003).
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RX PUBMED: 11788583.
RA Ku N. O., Azhar S., Omary M. B.
RT Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation
RL J. Biol. Chem. 277:10775-82 (2002).
RN [30]; RE0041034.
RX PUBMED: 10929041.
RA Song S., Freedman J., Mody M., Lazarus A. H.
RT Porcine von Willebrand factor and thrombin induce the activation of c-Jun amino-terminal kinase (JNK/SAPK) whereas only thrombin induces activation of extracellular signal-related kinase 2 (ERK2) in human platelets
RL Br. J. Haematol. 109:851-6 (2000).
RN [31]; RE0041215.
RX PUBMED: 12536241.
RA Garcia-Lora A., Martinez M., Pedrinaci S., Garrido F.
RT Different regulation of PKC isoenzymes and MAPK by PSK and IL-2 in the proliferative and cytotoxic activities of the NKL human natural killer cell line
RL Cancer Immunol. Immunother. 52:59-64 (2003).
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RX PUBMED: 15047162.
RA Seko Y., Fujimura T., Taka H., Mineki R., Murayama K., Nagai R.
RT Hypoxia followed by reoxygenation induces secretion of cyclophilin A from cultured rat cardiac myocytes
RL Biochem. Biophys. Res. Commun. 317:162-8 (2004).
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RA Crockett D. K., Lin Z., Elenitoba-Johnson K. S., Lim M. S.
RT Identification of NPM-ALK interacting proteins by tandem mass spectrometry
RL Oncogene 23:2617-29 (2004).
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RA Xu Y. J., Ouk Kim S., Liao D. F., Katz S., Pelech S. L.
RT Stimulation of 90- and 70-kDa ribosomal protein S6 kinases by arginine vasopressin and lysophosphatidic acid in rat cardiomyocytes
RL Biochem. Pharmacol. 59:1163-71 (2000).
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RX PUBMED: 9760105.
RA Bevan N., Scott S., Shaw P. E., Lee M. G., Marshall F. H., Rees S.
RT Nociception activates Elk-1 and Sap1a following expression of the ORL1 receptor in Chinese hamster ovary cells
RL Neuroreport 9:2703-8 (1998).
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RA Liu Y. Z., Thomas N. S., Latchman D. S.
RT CBP associates with the p42/p44 MAPK enzymes and is phosphorylated following NGF treatment
RL Neuroreport 10:1239-43 (1999).
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RA Channavajhala P. L., Wu L., Cuozzo J. W., Hall J. P., Liu W., Lin L. L., Zhang Y.
RT Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling
RL J. Biol. Chem. 278:47089-97 (2003).
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RA Robinson F. L., Whitehurst A. W., Raman M., Cobb M. H.
RT Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1
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RX PUBMED: 12907645.
RA Lee D. H., Yang Y., Lee S. J., Kim K. Y., Koo T. H., Shin S. M., Song K. S., Lee Y. H., Kim Y. J., Lee J. J., Choi I., Lee J. H.
RT Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system
RL Cancer Res. 63:4648-55 (2003).
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RA Kawaguchi M., Onuchic L. F., Huang S. K.
RT Activation of extracellular signal-regulated kinase (ERK)1/2, but not p38 and c-Jun N-terminal kinase, is involved in signaling of a novel cytokine, ML-1
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RA Majidi M., Hubbs A. E., Lichy J. H.
RT Activation of extracellular signal-regulated kinase 2 by a novel Abl-binding protein, ST5
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RA Reibman J., Hsu Y., Chen L. C., Bleck B., Gordon T.
RT Airway epithelial cells release MIP-3alpha/CCL20 in response to cytokines and ambient particulate matter
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RA Ogier-Denis E., Pattingre S., El Benna J., Codogno P.
RT Erk1/2-dependent phosphorylation of galpha -interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells
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RA Fan H., Villegas C., Wright J. A.
RT Ribonucleotide reductase R2 component is a novel malignancy determinant that cooperates with activated oncogenes to determine transformation and malignant potential
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RA Charlesworth A., Rozengurt E.
RT Bombesin and neuromedin B stimulate the activation of p42(mapk) and p74(raf-1) via a protein kinase C-independent pathway in Rat-1 cells
RL Oncogene 14:2323-9 (1997).
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RA Dhennin-Duthille I., Masson M., Damiens E., Fillebeen C., Spik G., Mazurier J.
RT Lactoferrin upregulates the expression of CD4 antigen through the stimulation of the mitogen-activated protein kinase in the human lymphoblastic T Jurkat cell line
RL J. Cell. Biochem. 79:583-93 (2000).
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RA Ayroldi E., Zollo O., Macchiarulo A., Di Marco B., Marchetti C., Riccardi C.
RT Glucocorticoid-induced leucine zipper inhibits the Raf-extracellular signal-regulated kinase pathway by binding to Raf-1
RL Mol. Cell. Biol. 22:7929-41 (2002).
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RA Midwinter R. G., Vissers M. C., Winterbourn C. C.
RT Hypochlorous acid stimulation of the mitogen-activated protein kinase pathway enhances cell survival
RL Arch. Biochem. Biophys. 394:13-20 (2001).
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RA Masri B., Lahlou H., Mazarguil H., Knibiehler B., Audigier Y.
RT Apelin (65-77) Activates Extracellular Signal-Regulated Kinases via a PTX-Sensitive G Protein
RL Biochem. Biophys. Res. Commun. 290:539-45 (2002).
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RA Zhang W., Chen T., Wan T., He L., Li N., Yuan Z., Cao X.
RT Cloning of DPK, a novel dendritic cell-derived protein kinase activating the ERK1/ERK2 and JNK/SAPK pathways
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RA Zhang Y., Dong Z., Nomura M., Zhong S., Chen N., Bode A. M., Dong Z.
RT Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation
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RA Veeranna, Shetty K. T., Takahashi M., Grant P., Pant H. C., Veeranna G. J.
RT Cdk5 and MAPK are associated with complexes of cytoskeletal proteins in rat brain
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RA Veeranna, Amin N. D., Ahn N. G., Jaffe H., Winters C. A., Grant P., Pant H. C.
RT Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M
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RA Celetti A., Cerrato A., Merolla F., Vitagliano D., Vecchio G., Grieco M.
RT H4(D10S170), a gene frequently rearranged with RET in papillary thyroid carcinomas: functional characterization
RL Oncogene 23:109-21 (2004).
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RA Murphy L. O., MacKeigan J. P., Blenis J.
RT A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration
RL Mol. Cell. Biol. 24:144-53 (2004).
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RA Goedert M., Cohen E. S., Jakes R., Cohen P.
RT p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]
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RA Tokuda H., Kozawa O., Niwa M., Matsuno H., Kato K., Uematsu T.
RT Mechanism of prostaglandin E2-stimulated heat shock protein 27 induction in osteoblast-like MC3T3-E1 cells
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RA Kadowaki Y., Ishihara S., Miyaoka Y., Rumi M. A., Sato H., Kazumori H., Adachi K., Takasawa S., Okamoto H., Chiba T., Kinoshita Y.
RT Reg protein is overexpressed in gastric cancer cells, where it activates a signal transduction pathway that converges on ERK1/2 to stimulate growth
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RA Chen Y., Alm K., Vujcic S., Kramer D. L., Kee K., Diegelman P., Porter C. W.
RT The role of mitogen-activated protein kinase activation in determining cellular outcomes in polyamine analogue-treated human melanoma cells
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RA Noguchi K., Kitanaka C., Yamana H., Kokubu A., Mochizuki T., Kuchino Y.
RT Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase
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RA Kansy J. W., Daubner S. C., Nishi A., Sotogaku N., Lloyd M. D., Nguyen C., Lu L., Haycock J. W., Hope B. T., Fitzpatrick P. F., Bibb J. A.
RT Identification of tyrosine hydroxylase as a physiological substrate for Cdk5
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RA Iida M., Towatari M., Nakao A., Iida H., Kiyoi H., Nakano Y., Tanimoto M., Saito H., Naoe T.
RT Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation
RL Leukemia 13:585-9 (1999).
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RA Davy A., Robbins S. M.
RT Ephrin-A5 modulates cell adhesion and morphology in an integrin-dependent manner
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RA Oh-hora M., Ogata M., Mori Y., Adachi M., Imai K., Kosugi A., Hamaoka T.
RT Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase
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RA Panenka W., Jijon H., Herx L. M., Armstrong J. N., Feighan D., Wei T., Yong V. W., Ransohoff R. M., MacVicar B. A.
RT P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase
RL J. Neurosci. 21:7135-42 (2001).
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RA Ko L., Cardona G. R., Henrion-Caude A., Chin W. W.
RT Identification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors.
RL Mol. Cell. Biol. 22:357-369 (2002).
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RA Kotzka J., Lehr S., Roth G., Avci H., Knebel B., Muller-Wieland D.
RT Insulin-activated Erk-mitogen-activated protein kinases phosphorylate sterol regulatory element-binding Protein-2 at serine residues 432 and 455 in vivo.
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RA Tanos T., Marinissen M. J., Leskow F. C., Hochbaum D., Martinetto H., Gutkind J. S., Coso O. A.
RT Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light.
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RA Cho Y. Y., He Z., Zhang Y., Choi H. S., Zhu F., Choi B. Y., Kang B. S., Ma W. Y., Bode A. M., Dong Z.
RT The p53 protein is a novel substrate of ribosomal S6 kinase 2 and a critical intermediary for ribosomal S6 kinase 2 and histone H3 interaction.
RL Cancer Res. 65:3596-3603 (2005).
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RA Van Slyke P., Coll M. L., Master Z., Kim H., Filmus J., Dumont D. J.
RT Dok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk.
RL Mol. Cell. Biol. 25:3831-3841 (2005).
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RA Lutterbach B., Hann S. R.
RT Hierarchical phosphorylation at N-terminal transformation-sensitive sites in c-Myc protein is regulated by mitogens and in mitosis.
RL Mol. Cell. Biol. 14:5510-5522 (1994).
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RA Aoki H., Hayashi J., Moriyama M., Arakawa Y., Hino O.
RT Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1.
RL J. Virol. 74:1736-1741 (2000).
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RA Reed K. E., Rice C. M.
RT Identification of the major phosphorylation site of the hepatitis C virus H strain NS5A protein as serine 2321.
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RA Wunderlich W., Fialka I., Teis D., Alpi A., Pfeifer A., Parton R. G., Lottspeich F., Huber L. A.
RT A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment.
RL J. Cell Biol. 152:765-776 (2001).
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RA Cunnick J. M., Mei L., Doupnik C. A., Wu J.
RT Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2.
RL J. Biol. Chem. 276:24380-24387 (2001).
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RA Seta K., Sadoshima J.
RT Phosphorylation of tyrosine 319 of the angiotensin II type 1 receptor mediates angiotensin II-induced trans-activation of the epidermal growth factor receptor.
RL J. Biol. Chem. 278:9019-9026 (2003).
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RA McCoy C. E., MacDonald A., Morrice N. A., Campbell D. G., Deak M., Toth R., McIlrath J., Arthur J. S.
RT Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS.
RL Biochem. J. 402:491-501 (2007).
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RA Wiegert J. S., Bengtson C. P., Bading H.
RT Diffusion and not active transport underlies and limits ERK1/2 synapse-to-nucleus signaling in hippocampal neurons.
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RA Zhang T., Jia N., Fei E., Wang P., Liao Z., Ding L., Yan M., Nukina N., Zhou J., Wang G.
RT Nurr1 is phosphorylated by ERK2 in vitro and its phosphorylation upregulates tyrosine hydroxylase expression in SH-SY5Y cells.
RL Neurosci. Lett. 423:118-122 (2007).
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RT Peptide substrates for ERK1/2: structure-function studies of serine 31 in tyrosine hydroxylase.
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RT Jak2 tyrosine kinase mediates angiotensin II-dependent inactivation of ERK2 via induction of mitogen-activated protein kinase phosphatase 1.
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RT Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells.
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RT Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene.
RL Mol. Endocrinol. 21:1216-1233 (2007).
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RT Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5.
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RT Identification of the minimal tyrosine residues required for linker for activation of T cell function.
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RA King J. A., Straffon A. F., D'Abaco G. M., Poon C. L., I S. T., Smith C. M., Buchert M., Corcoran N. M., Hall N. E., Callus B. A., Sarcevic B., Martin D., Lock P., Hovens C. M.
RT Distinct requirements for the Sprouty domain for functional activity of Spred proteins.
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RA Chandramouli S., Yu C. Y., Yusoff P., Lao D. H., Leong H. F., Mizuno K., Guy G. R.
RT Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.
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RA Cervenka I., Wolf J., Masek J., Krejci P., Wilcox W. R., Kozubik A., Schulte G., Gutkind J. S., Bryja V.
RT Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6.
RL Mol. Cell. Biol. 31:179-189 (2011).
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RT Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling.
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RT Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.
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RT Rac is activated by tumor necrosis factor alpha and is involved in activation of Erk.
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RA Danson C. M., Pocha S. M., Bloomberg G. B., Cory G. O.
RT Phosphorylation of WAVE2 by MAP kinases regulates persistent cell migration and polarity.
RL J. Cell Sci. 120:4144-4154 (2007).
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