AC T10108
XX
ID T10108
XX
DT 10.01.2007 (created); sts.
CO Copyright (C), QIAGEN.
XX
FA NURR1-isoform1
XX
SY NOT; NR4A2; Nur-related factor 1; Nurr1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G002229 NR4A2; HGNC: NR4A2.
XX
CL C0002; CC (rec).
XX
SZ 598 AA; 66.6 kDa (cDNA) (calc.).
XX
SQ MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSF
SQ STFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMPHSGSV
SQ YYKPSSPPTPTTPGFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQ
SQ SPPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHA
SQ SQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCL
SQ ANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQEPSPPSP
SQ PVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGW
SQ AEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFG
SQ EWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVT
SQ FNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF
XX
SC Swiss-Prot#P43354
XX
FT 26 406 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 260 331 
SM00399; c4gold.
FT 260 335 
PS51030; NUCLEAR_REC_DBD_2.
FT 261 336 
PF00105; Zinc finger, C4 type (two domains).
FT 408 566 
SM00430; holi.
FT 411 591 
PF00104; Ligand-binding domain of nuclear hormon.
FT 583 596 
AF-2 (activation function 2) core region [4].
XX
FF induces maturation of both murine MM13 and human H9 embryonic stem cell to the midbrain dopamine neuron phenotype in co-ordination with Pitx3 T04311 [8];
XX
IN T17209 ERK2; Mammalia.
XX
MX M02273 V$NR4A2_01.
MX M01269 V$NURR1_Q3.
MX M07427 V$NURR1_Q3_01.
XX
BS R58986.
BS R58987.
BS R58988.
XX
DR TRANSPATH: MO000095970.
DR EMBL: X75918;
DR UniProtKB: P43354;
XX
RN [1]; RE0013625.
RX PUBMED: 10219237.
RA Nuclear Receptors Nomenclature Committee.
RT A unified nomenclature system for the nuclear receptor superfamily
RL Cell 97:161-163 (1999).
RN [2]; RE0013631.
RX PUBMED: 7877627.
RA Mages H. W., Rilke O., Bravo R., Senger G., Kroczek R. A.
RT NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3
RL Mol. Endocrinol. 8:1583-1591 (1994).
RN [3]; RE0016856.
RX PUBMED: 11121187.
RA Buervenich S., Carmine A., Arvidsson M., Xiang F., Zhang Z., Sydow O., Jonsson E. G., Sedvall G. C., Leonard S., Ross R. G., Freedman R., Chowdari K. V., Nimgaonkar V. L., Perlmann T., Anvret M., Olson L.
RT NURR1 mutations in cases of schizophrenia and manic-depressive disorder
RL Am. J. Med. Genet. 96:808-813 (2000).
RN [4]; RE0016859.
RX PUBMED: 10601324.
RA Castro D. S., Arvidsson M., Bondesson Bolin M., Perlmann T.
RT Activity of the Nurr1 carboxyl-terminal domain depends on cell type and integrity of the activation function 2
RL J. Biol. Chem. 274:37483-37490 (1999).
RN [5]; RE0016863.
RX PUBMED: 11159837.
RA Tetradis S., Bezouglaia O., Tsingotjidou A.
RT Parathyroid hormone induces expression of the nuclear orphan receptor Nurr1 in bone cells
RL Endocrinology 142:663-670 (2001).
RN [6]; RE0016872.
RX PUBMED: 9070291.
RA Maruyama K., Tsukada T., Bandoh S., Sasaki K., Ohkura N., Yamaguchi K.
RT Retinoic acids differentially regulate NOR-1 and its closely related orphan nuclear receptor genes in breast cancer cell line MCF-7
RL Biochem. Biophys. Res. Commun. 231:417-420 (1997).
RN [7]; RE0051501.
RX PUBMED: 17681692.
RA Zhang T., Jia N., Fei E., Wang P., Liao Z., Ding L., Yan M., Nukina N., Zhou J., Wang G.
RT Nurr1 is phosphorylated by ERK2 in vitro and its phosphorylation upregulates tyrosine hydroxylase expression in SH-SY5Y cells.
RL Neurosci. Lett. 423:118-122 (2007).
RN [8]; RE0051892.
RX PUBMED: 16477036.
RA Martinat C., Bacci J. J., Leete T., Kim J., Vanti W. B., Newman A. H., Cha J. H., Gether U., Wang H., Abeliovich A.
RT Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype.
RL Proc. Natl. Acad. Sci. USA 103:2874-2879 (2006).
XX
//