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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T08513 XX ID T08513 XX DT 31.01.2006 (created); din. DT 09.02.2015 (updated); ros. CO Copyright (C), QIAGEN. XX FA pRb XX SY p105-RB; pp110; Rb; retinoblastoma tumor suppressor protein; retinoblastoma-associated protein. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G001086 RB1; HGNC: RB1. XX SZ 928 AA; 106.2 kDa (cDNA) (calc.). XX SQ MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTAL SQ CQKLKIPDHVRERAWLTWEKVSSVDGVLGGYIQKKKELWGICIFIAAVDLDEMSFTFTEL SQ QKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSS SQ ISTEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYK SQ TAVIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECNIDEVKNVYFKNFIPFM SQ NSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKS SQ NLDEEVNVIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVK SQ DIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDN SQ IFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEG SQ NLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNH SQ TAADMYLSPVRSPKKKGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYL SQ RLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLK SQ FKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLS SQ PIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFG SQ TSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQK SQ LAEMTSTRTRMQKQKMNDSMDTSNKEEK XX SC translated from EMBL:M28419 XX FT 346 680 PF00478; IMP dehydrogenase / GMP reductase domain. FT 373 573 PF01858; Retinoblastoma-associated protein A domain. FT 645 766 PF01857; Retinoblastoma-associated protein B domain. FT 660 761 SM00385; cyclin_7. XX IN T01542 E2F-1; human, Homo sapiens. IN T09570 E2F-1; Mammalia. IN T34277 mcm7; human, Homo sapiens. IN T08615 PLZFB; human, Homo sapiens. IN T14535 TBX2; Mammalia. XX BS R00326. BS R60975. XX DR TRANSPATH: MO000059270. DR EMBL: M15400; HSRBS. DR EMBL: M28419; HSRBSA. DR EMBL: M33647; HSRB1RA. DR EMBL: X16439; HSRB1G. DR UniProtKB: P06400; XX RN [1]; RE0049236. RX PUBMED: 11073990. RA MacLellan W. R., Xiao G., Abdellatif M., Schneider M. D. RT A novel Rb- and p300-binding protein inhibits transactivation by MyoD. RL Mol. Cell. Biol. 20:8903-8915 (2000). RN [2]; RE0049630. RX PUBMED: 16374512. RA Markham D., Munro S., Soloway J., O'Connor D. P., La Thangue N. B. RT DNA-damage-responsive acetylation of pRb regulates binding to E2F-1. RL EMBO Rep. 7:192-198 (2006). RN [3]; RE0049669. RX PUBMED: 16332962. RA Munakata T., Nakamura M., Liang Y., Li K., Lemon S. M. RT Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymerase. RL Proc. Natl. Acad. Sci. USA 102:18159-18164 (2005). RN [4]; RE0052687. RX PUBMED: 12682072. RA Balasenthil S., Vadlamudi R. K. RT Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein. RL J. Biol. Chem. 278:22119-22127 (2003). RN [5]; RE0069339. RX PUBMED: 20668449. RA Tooley C. E., Petkowski J. J., Muratore-Schroeder T. L., Balsbaugh J. L., Shabanowitz J., Sabat M., Minor W., Hunt D. F., Macara I. G. RT NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein. RL Nature 466:1125-1128 (2010). RN [6]; RE0070917. RX PUBMED: 20534814. RA Vance K. W., Shaw H. M., Rodriguez M., Ott S., Goding C. R. RT The retinoblastoma protein modulates Tbx2 functional specificity. RL Mol. Biol. Cell 21:2770-2779 (2010). XX //