AC T08513
XX
ID T08513
XX
DT 31.01.2006 (created); din.
DT 09.02.2015 (updated); ros.
CO Copyright (C), QIAGEN.
XX
FA pRb
XX
SY p105-RB; pp110; Rb; retinoblastoma tumor suppressor protein; retinoblastoma-associated protein.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G001086 RB1; HGNC: RB1.
XX
SZ 928 AA; 106.2 kDa (cDNA) (calc.).
XX
SQ MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTAL
SQ CQKLKIPDHVRERAWLTWEKVSSVDGVLGGYIQKKKELWGICIFIAAVDLDEMSFTFTEL
SQ QKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSS
SQ ISTEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYK
SQ TAVIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECNIDEVKNVYFKNFIPFM
SQ NSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKS
SQ NLDEEVNVIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVK
SQ DIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDN
SQ IFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEG
SQ NLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNH
SQ TAADMYLSPVRSPKKKGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYL
SQ RLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLK
SQ FKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLS
SQ PIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFG
SQ TSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQK
SQ LAEMTSTRTRMQKQKMNDSMDTSNKEEK
XX
SC translated from EMBL:M28419
XX
FT 346 680 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 373 573 
PF01858; Retinoblastoma-associated protein A domain.
FT 645 766 
PF01857; Retinoblastoma-associated protein B domain.
FT 660 761 
SM00385; cyclin_7.
XX
IN T01542 E2F-1; human, Homo sapiens.
IN T09570 E2F-1; Mammalia.
IN T34277 mcm7; human, Homo sapiens.
IN T08615 PLZFB; human, Homo sapiens.
IN T14535 TBX2; Mammalia.
XX
BS R00326.
BS R60975.
XX
DR TRANSPATH: MO000059270.
DR EMBL: M15400; HSRBS.
DR EMBL: M28419; HSRBSA.
DR EMBL: M33647; HSRB1RA.
DR EMBL: X16439; HSRB1G.
DR UniProtKB: P06400;
XX
RN [1]; RE0049236.
RX PUBMED: 11073990.
RA MacLellan W. R., Xiao G., Abdellatif M., Schneider M. D.
RT A novel Rb- and p300-binding protein inhibits transactivation by MyoD.
RL Mol. Cell. Biol. 20:8903-8915 (2000).
RN [2]; RE0049630.
RX PUBMED: 16374512.
RA Markham D., Munro S., Soloway J., O'Connor D. P., La Thangue N. B.
RT DNA-damage-responsive acetylation of pRb regulates binding to E2F-1.
RL EMBO Rep. 7:192-198 (2006).
RN [3]; RE0049669.
RX PUBMED: 16332962.
RA Munakata T., Nakamura M., Liang Y., Li K., Lemon S. M.
RT Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymerase.
RL Proc. Natl. Acad. Sci. USA 102:18159-18164 (2005).
RN [4]; RE0052687.
RX PUBMED: 12682072.
RA Balasenthil S., Vadlamudi R. K.
RT Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein.
RL J. Biol. Chem. 278:22119-22127 (2003).
RN [5]; RE0069339.
RX PUBMED: 20668449.
RA Tooley C. E., Petkowski J. J., Muratore-Schroeder T. L., Balsbaugh J. L., Shabanowitz J., Sabat M., Minor W., Hunt D. F., Macara I. G.
RT NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
RL Nature 466:1125-1128 (2010).
RN [6]; RE0070917.
RX PUBMED: 20534814.
RA Vance K. W., Shaw H. M., Rodriguez M., Ott S., Goding C. R.
RT The retinoblastoma protein modulates Tbx2 functional specificity.
RL Mol. Biol. Cell 21:2770-2779 (2010).
XX
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