AC T23419
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ID T23419
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DT 11.11.2009 (created); jig.
CO Copyright (C), QIAGEN.
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FA MCT-isoform1
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SY BRIT1; FLJ12847; MCPH1; MCT; microcephaly, primary autosomal recessive 1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G034966 MCPH1; HGNC: MCPH1.
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SZ 835 AA; 92.8 kDa (cDNA) (calc.).
XX
SQ MAAPILKDVVAYVEVWSSNGTENYSKTFTTQLVDMGAKVSKTFNKQVTHVIFKDGYQSTW
SQ DKAQKRGVKLVSVLWVEKCRTAGAHIDESLFPAANMNEHLSSLIKKKRKCMQPKDFNFKT
SQ PENDKRFQKKFEKMAKELQRQKTNLDDDVPILLFESNGSLIYTPTIEINSSHHSAMEKRL
SQ QEMKEKRENLSPTSSQMIQQSHDNPSNSLCEAPLNISRDTLCSDEYFAGGLHSSFDDLCG
SQ NSGCGNQERKLEGSINDIKSDVCISSLVLKANNIHSSPSFTHLDKSSPQKFLSNLSKEEI
SQ NLQRNIAGKVVTPHQKQAAGMSQETFEEKYRLSPTLSSTKGHLLIHSRPRSSSVKRKRVS
SQ HGSHSPPKEKCKRKRSTRRSIMPRLQLCRSEGRLQHVAGPALEALSCGESSYDDYFSPDN
SQ LKERYSENLPPESQLPSSPAQLSCRSLSKKERTSIFEMSDFSCVGKKTRTVDITNFTAKT
SQ ISSPRKTGNGEGRATSSCVTSAPEEALRCCRQAGKEDACPEGNGFSYTIEDPALPKGHDD
SQ DLTPLEGSLEEMKEAVGLKSTQNKGTTSKISNSSEGEAQSEHEPCFIVDCNMETSTEEKE
SQ NLPGGYSGSVKNRPTRHDVLDDSCDGFKDLIKPHEELKKSGRGKKPTRTLVMTSMPSEKQ
SQ NVVIQVVDKLKGFSIAPDVCETTTHVLSGKPLRTLNVLLGIARGCWVLSYDWVLWSLELG
SQ HWISEEPFELSHHFPAAPLCRSECHLSAGPYRGTLFADQPVMFVSPASSPPVAKLCELVH
SQ LCGGRVSQVPRQASIVIGPYSGKKKATVKYLSEKWVLDSITQHKVCAPENYLLSQ
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SC Swiss-Prot#Q8NEM0-1
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IN T01542 E2F-1; human, Homo sapiens.
IN T09570 E2F-1; Mammalia.
IN T17403 E2F-2; Mammalia.
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BS R38295.
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DR TRANSPATH: MO000164835.
DR UniProtKB: Q8NEM0-1;
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RN [1]; RE0064713.
RX PUBMED: 17925396.
RA Wood J. L., Singh N., Mer G., Chen J.
RT MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage.
RL J. Biol. Chem. 282:35416-35423 (2007).
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//