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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T09462 XX ID T09462 XX DT 11.10.2006 (created); tgo. DT 09.04.2014 (updated); jmh. CO Copyright (C), QIAGEN. XX FA Egr-1 XX SY AT225; early growth response protein 1; Early Growth Responsive factor 1; Egr-1; ETR103; Krox-24; NGFI-A; zif268. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G002144 EGR1; HGNC: EGR1. XX CL C0001; CH. XX SZ 543 AA; 57.5 kDa (cDNA) (calc.), 80 kDa (SDS) [2] XX SQ MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNGAPQFLGAAGAPEGSGS SQ NSSSSSSGGGGGGGGGSNSSSSSSTFNPQADTGEQPYEHLTAESFPDISLNNEKVLVETS SQ YPSQTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPASSSSAPSPAAS SQ SASASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAY SQ PAAKGGFQVPMIPDYLFPQQQGDLGLGTPDQKPFQGLESRTQQPSLTPLSTIKAFATQSG SQ SQDLKALNTSYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIR SQ IHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLR SQ QKDKKADKSVVASSATSSLSSYPSPVATSYPSPVTTSYPSPATTSYPSPVPTSFSSPGSS SQ TYPSPVHSGFPSPSVATTYSSVPPAFPAQVSSFPSSAVTNSFSASTGLSDMTATFSPRTI SQ EIC XX SC Swiss-Prot#P18146 XX FT 338 362 PF00096; zf-C2H2. FT 338 362 SM00355; c2h2final6. FT 338 367 PS50157; ZINC_FINGER_C2H2_2. FT 368 390 PF00096; zf-C2H2. FT 368 390 SM00355; c2h2final6. FT 368 395 PS50157; ZINC_FINGER_C2H2_2. FT 396 418 PF00096; zf-C2H2. FT 396 418 SM00355; c2h2final6. FT 396 423 PS50157; ZINC_FINGER_C2H2_2. XX IN T11025 NFATc1; Mammalia. IN T11024 NFATc2; Mammalia. IN T08711 RelA-p65; human, Homo sapiens. XX MX M00243 V$EGR1_01. MX M07354 V$EGR1_Q3. MX M01873 V$EGR1_Q6. MX M08878 V$EGR_Q3. MX M00807 V$EGR_Q6. MX M00982 V$KROX_Q6. XX BS R58660. BS R04926. BS R04927. BS R16963. BS R14966. BS R57448. BS R13412. BS R61228. BS R24214. BS R24773. BS R24774. BS R24775. BS R17082. BS R17083. BS R14632. BS R35461. BS R35463. BS R35466. BS R35467. BS R35468. BS R21248. XX DR TRANSPATH: MO000088889. DR TRANSCOMPEL: C00530. DR TRANSCOMPEL: C00647. DR TRANSCOMPEL: C00648. DR EMBL: M62829; HSETR103. DR EMBL: M80583; HSZINFING. DR EMBL: X52541; HSEGR1. DR UniProtKB: P18146; EGR1_HUMAN. XX RN [1]; RE0002677. RX PUBMED: 2110381. RA Wright J. J., Gunter K. C., Mitsuya H., Irving St. G., Kelly K., Siebenlist U. RT Expression of a zinc finger gene in HTLV-I- and HTLV-II-transformed cells RL Science 248:588-591 (1990). RN [2]; RE0006699. RX PUBMED: 7983016. RA Cheng T., Wang Y., Dai W. RT Transcription factor egr-1 is involved in phorbol 12-myristate 13-acetate-induced megakaryocytic differentiation of K562 cells RL J. Biol. Chem. 269:30848-30853 (1994). RN [3]; RE0011295. RX PUBMED: 7673240. RA Skerka C., Decker E. L., Zipfel P. F. RT A regulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and EGR-1 RL J. Biol. Chem. 270:22500-22506 (1995). RN [4]; RE0017818. RX PUBMED: 10508276. RA Li-Weber M., Laur O., Krammer P. H. RT Novel Egr/NF-AT composite sites mediate activation of the CD95 (APO-1/Fas) ligand promoter in response to T cell stimulation. RL Eur. J. Immunol. 29:3017-3027 (1999). RN [5]; RE0022849. RX PUBMED: 9756940. RA Decker E. L., Skerka C., Zipfel P. F. RT The early growth response protein (EGR-1) regulates interleukin-2 transcription by synergistic interaction with the nuclear factor of activated T cells. RL J. Biol. Chem. 273:26923-26930 (1998). RN [6]; RE0024298. RX PUBMED: 9880555. RA Lehmann U., Brocke P., Dittmer J., Nordheim A. RT Characterization of the human elk-1 promoter. Potential role of a downstream intronic sequence for elk-1 gene expression in monocytes. RL J. Biol. Chem. 274:1736-1744 (1999). RN [7]; RE0030092. RX PUBMED: 12560487. RA Decker E. L., Nehmann N., Kampen E., Eibel H., Zipfel P. F., Skerka C. RT Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression. RL Nucleic Acids Res. 31:911-21 (2003). RN [8]; RE0049019. RX PUBMED: 12569082. RA Zhang X., Liu Y. RT Suppression of HGF receptor gene expression by oxidative stress is mediated through the interplay between Sp1 and Egr-1. RL Am. J. Physiol. Renal Physiol. 284:F1216-25 (2003). RN [9]; RE0049054. RX PUBMED: 10671503. RA Chapman N. R., Perkins N. D. RT Inhibition of the RelA(p65) NF-kappaB subunit by Egr-1. RL J. Biol. Chem. 275:4719-4725 (2000). XX //