AC T09462
XX
ID T09462
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DT 11.10.2006 (created); tgo.
DT 09.04.2014 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA Egr-1
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SY AT225; early growth response protein 1; Early Growth Responsive factor 1; Egr-1; ETR103; Krox-24; NGFI-A; zif268.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002144 EGR1; HGNC: EGR1.
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CL C0001; CH.
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SZ 543 AA; 57.5 kDa (cDNA) (calc.), 80 kDa (SDS) [2]
XX
SQ MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNGAPQFLGAAGAPEGSGS
SQ NSSSSSSGGGGGGGGGSNSSSSSSTFNPQADTGEQPYEHLTAESFPDISLNNEKVLVETS
SQ YPSQTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPASSSSAPSPAAS
SQ SASASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAY
SQ PAAKGGFQVPMIPDYLFPQQQGDLGLGTPDQKPFQGLESRTQQPSLTPLSTIKAFATQSG
SQ SQDLKALNTSYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIR
SQ IHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLR
SQ QKDKKADKSVVASSATSSLSSYPSPVATSYPSPVTTSYPSPATTSYPSPVPTSFSSPGSS
SQ TYPSPVHSGFPSPSVATTYSSVPPAFPAQVSSFPSSAVTNSFSASTGLSDMTATFSPRTI
SQ EIC
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SC Swiss-Prot#P18146
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FT 338 362 
PF00096; zf-C2H2.
FT 338 362 
SM00355; c2h2final6.
FT 338 367 
PS50157; ZINC_FINGER_C2H2_2.
FT 368 390 
PF00096; zf-C2H2.
FT 368 390 
SM00355; c2h2final6.
FT 368 395 
PS50157; ZINC_FINGER_C2H2_2.
FT 396 418 
PF00096; zf-C2H2.
FT 396 418 
SM00355; c2h2final6.
FT 396 423 
PS50157; ZINC_FINGER_C2H2_2.
XX
IN T11025 NFATc1; Mammalia.
IN T11024 NFATc2; Mammalia.
IN T08711 RelA-p65; human, Homo sapiens.
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MX M00243 V$EGR1_01.
MX M07354 V$EGR1_Q3.
MX M01873 V$EGR1_Q6.
MX M08878 V$EGR_Q3.
MX M00807 V$EGR_Q6.
MX M00982 V$KROX_Q6.
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BS R58660.
BS R04926.
BS R04927.
BS R16963.
BS R14966.
BS R57448.
BS R13412.
BS R61228.
BS R24214.
BS R24773.
BS R24774.
BS R24775.
BS R17082.
BS R17083.
BS R14632.
BS R35461.
BS R35463.
BS R35466.
BS R35467.
BS R35468.
BS R21248.
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DR TRANSPATH: MO000088889.
DR TRANSCOMPEL: C00530.
DR TRANSCOMPEL: C00647.
DR TRANSCOMPEL: C00648.
DR EMBL: M62829; HSETR103.
DR EMBL: M80583; HSZINFING.
DR EMBL: X52541; HSEGR1.
DR UniProtKB: P18146; EGR1_HUMAN.
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RN [1]; RE0002677.
RX PUBMED: 2110381.
RA Wright J. J., Gunter K. C., Mitsuya H., Irving St. G., Kelly K., Siebenlist U.
RT Expression of a zinc finger gene in HTLV-I- and HTLV-II-transformed cells
RL Science 248:588-591 (1990).
RN [2]; RE0006699.
RX PUBMED: 7983016.
RA Cheng T., Wang Y., Dai W.
RT Transcription factor egr-1 is involved in phorbol 12-myristate 13-acetate-induced megakaryocytic differentiation of K562 cells
RL J. Biol. Chem. 269:30848-30853 (1994).
RN [3]; RE0011295.
RX PUBMED: 7673240.
RA Skerka C., Decker E. L., Zipfel P. F.
RT A regulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and EGR-1
RL J. Biol. Chem. 270:22500-22506 (1995).
RN [4]; RE0017818.
RX PUBMED: 10508276.
RA Li-Weber M., Laur O., Krammer P. H.
RT Novel Egr/NF-AT composite sites mediate activation of the CD95 (APO-1/Fas) ligand promoter in response to T cell stimulation.
RL Eur. J. Immunol. 29:3017-3027 (1999).
RN [5]; RE0022849.
RX PUBMED: 9756940.
RA Decker E. L., Skerka C., Zipfel P. F.
RT The early growth response protein (EGR-1) regulates interleukin-2 transcription by synergistic interaction with the nuclear factor of activated T cells.
RL J. Biol. Chem. 273:26923-26930 (1998).
RN [6]; RE0024298.
RX PUBMED: 9880555.
RA Lehmann U., Brocke P., Dittmer J., Nordheim A.
RT Characterization of the human elk-1 promoter. Potential role of a downstream intronic sequence for elk-1 gene expression in monocytes.
RL J. Biol. Chem. 274:1736-1744 (1999).
RN [7]; RE0030092.
RX PUBMED: 12560487.
RA Decker E. L., Nehmann N., Kampen E., Eibel H., Zipfel P. F., Skerka C.
RT Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression.
RL Nucleic Acids Res. 31:911-21 (2003).
RN [8]; RE0049019.
RX PUBMED: 12569082.
RA Zhang X., Liu Y.
RT Suppression of HGF receptor gene expression by oxidative stress is mediated through the interplay between Sp1 and Egr-1.
RL Am. J. Physiol. Renal Physiol. 284:F1216-25 (2003).
RN [9]; RE0049054.
RX PUBMED: 10671503.
RA Chapman N. R., Perkins N. D.
RT Inhibition of the RelA(p65) NF-kappaB subunit by Egr-1.
RL J. Biol. Chem. 275:4719-4725 (2000).
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