AC T04956
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ID T04956
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DT 28.11.2001 (created); rge.
DT 17.07.2014 (updated); msr.
CO Copyright (C), QIAGEN.
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FA FKLF
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SY FKLF; KLF11; TGFbeta-inducible early growth response protein 2; TIEG-2; TIEG2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006812 KLF11; HGNC: KLF11.
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CL C0001; CH; 2.3.1.2.11.
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CP Northern Blot; adult human tissues; strong expression in pancreas and skeletal muscle, further expression in heart, brain, placenta, lung, liver, kidney [1]; K562 cells, erythroid human fetal liver, erythroid cell lines, endothelial cell line [2] [1] [2]; human pancreatic islets, pancreatic beta cell lines HIT-T15, INS 832/13, beta TC3 and Min6 [3]; rat pancreas,INS-1E beta cells [4].
CN Jurkat cells, adult bone marrow, myeloid cell lines, lymphoid cell lines (17325).
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FF activator [1] [2];
FF activates human embryonic (epsilon) and fetal (gamma) globin gene transcription [2];
FF note that the N-terminal region of FKLF T04956 displays a dose-dependent transcriptional repressor activity, whereas the C-terminal region does not have any significant transcriptional regulatory activity over the control [1];
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IN T01427 p300; human, Homo sapiens.
IN T21984 p300; human, Homo sapiens.
IN T08711 RelA-p65; human, Homo sapiens.
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MX M05312 V$FKLF_01.
MX M01837 V$FKLF_Q5.
MX M07461 V$KLF_Q3.
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BS R15640.
BS R62905.
BS R62907.
BS R62910.
BS R15642.
BS R15643.
BS R15641.
BS R21016.
BS R21018.
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DR TRANSPATH: MO000028728.
DR UniProtKB: O14901;
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RN [1]; RE0017324.
RX PUBMED: 9748269.
RA Cook T., Gebelein B., Mesa K., Mladek A., Urrutia R.
RT Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth
RL J. Biol. Chem. 273:25929-25936 (1998).
RN [2]; RE0017325.
RX PUBMED: 10207080.
RA Asano H., Li X. S., Stamatoyannopoulos G.
RT FKLF, a novel Kruppel-like factor that activates human embryonic and fetal beta-like globin genes
RL Mol. Cell. Biol. 19:3571-3579 (1999).
RN [3]; RE0052405.
RX PUBMED: 15774581.
RA Neve B., Fernandez-Zapico M. E., Ashkenazi-Katalan V., Dina C., Hamid Y. H., Joly E., Vaillant E., Benmezroua Y., Durand E., Bakaher N., Delannoy V., Vaxillaire M., Cook T., Dallinga-Thie G. M., Jansen H., Charles M. A., Clement K., Galan P., Hercberg S., Helbecque N., Charpentier G., Prentki M., Hansen T., Pedersen O., Urrutia R., Melloul D., Froguel P.
RT Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function.
RL Proc. Natl. Acad. Sci. USA 102:4807-4812 (2005).
RN [4]; RE0052531.
RX PUBMED: 17479246.
RA Niu X., Perakakis N., Laubner K., Limbert C., Stahl T., Brendel M. D., Bretzel R. G., Seufert J., Path G.
RT Human Kruppel-like factor 11 inhibits human proinsulin promoter activity in pancreatic beta cells.
RL Diabetologia 50:1433-1441 (2007).
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