AC T06587
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ID T06587
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DT 11.07.2005 (created); elf.
DT 01.06.2015 (updated); asv.
CO Copyright (C), QIAGEN.
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FA Gfi1
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SY GFI1; growth factor independent 1; pal-1; Pal1; ZNF163.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G018223 GFI1; HGNC: GFI1.
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CL C0001; CH; 2.3.3.21.1.
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SF six C-terminal C2H2-type zinc finger domains and a characteristic stretch of 20 amino acids, called the SNAG domain, at its N-terminus [3];
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CP early stages of T-cell development, precursors of sensory neurons, the retina, specific cells of the lung and in the CNS [1]; developing epithelia of the inner ear, high in granulocytes, lymphopoietic thymus [3] [1] [3].
CN barely detected in erythroid precursors and megakaryocytes [1].
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FF repressor [1];
FF development of granulocytes and T-cell differentiation and macrophage-dependent cytokine production (defense against pathogens), required for the proper development of inner ear hair cells [3];
FF cooperator of Myc or Pim-1 in tumorigenesis [3];
FF 20 amino-acid, N-terminal repressor domain (SNAG), associated with oncogenesis and human neoplasms [5];
FF position- and orientation-independent active transcriptional repressor [4];
FF Gfi1 releases cells from a G1 block induced by IL-2 withdrawal and is targeted by proviral integration in a number of tumor systems [4];
FF role in stem cell differentiation [2];
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IN T08711 RelA-p65; human, Homo sapiens.
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MX M00250 V$GFI1_01.
MX M01067 V$GFI1_Q6.
MX M02010 V$GFI1_Q6_01.
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BS R61066.
BS R31946.
BS R38395.
BS R26763.
BS R39882.
BS R68020.
BS R16947.
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DR TRANSPATH: MO000056186.
DR UniProtKB: Q99684; GFI1_HUMAN.
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RN [1]; RE0035152.
RX PUBMED: 15718298.
RA Vassen L., Fiolka K., Mahlmann S., Moroy T.
RT Direct transcriptional repression of the genes encoding the zinc-finger proteins Gfi1b and Gfi1 by Gfi1b.
RL Nucleic Acids Res. 33:987-998 (2005).
RN [2]; RE0035164.
RX PUBMED: 12721361.
RA Duan Z., Horwitz M.
RT Targets of the transcriptional repressor oncoprotein Gfi-1.
RL Proc. Natl. Acad. Sci. USA 100:5932-5937 (2003).
RN [3]; RE0035165.
RX PUBMED: 15618011.
RA Moroy T.
RT The zinc finger transcription factor Growth factor independence 1 (Gfi1).
RL Int. J. Biochem. Cell Biol. 37:541-546 (2005).
RN [4]; RE0035172.
RX PUBMED: 8887656.
RA Grimes H. L., Chan T. O., Zweidler-McKay P. A., Tong B., Tsichlis P. N.
RT The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal.
RL Mol. Cell. Biol. 16:6263-6272 (1996).
RN [5]; RE0035232.
RX PUBMED: 8962093.
RA Grimes H. L., Gilks C. B., Chan T. O., Porter S., Tsichlis P. N.
RT The Gfi-1 protooncoprotein represses Bax expression and inhibits T-cell death.
RL Proc. Natl. Acad. Sci. USA 93:14569-14573 (1996).
RN [6]; RE0068548.
RX PUBMED: 20226183.
RA Jung J. H., Lee S. M., Bae S., Lee S. J., Park I. C., Jin Y. W., Lee J. H., An S.
RT Triad 1 induces apoptosis by p53 activation.
RL FEBS Lett. 584:1565-1570 (2010).
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