TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T06587 XX ID T06587 XX DT 11.07.2005 (created); elf. DT 01.06.2015 (updated); asv. CO Copyright (C), QIAGEN. XX FA Gfi1 XX SY GFI1; growth factor independent 1; pal-1; Pal1; ZNF163. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G018223 GFI1; HGNC: GFI1. XX CL C0001; CH; XX SF six C-terminal C2H2-type zinc finger domains and a characteristic stretch of 20 amino acids, called the SNAG domain, at its N-terminus [3]; XX CP early stages of T-cell development, precursors of sensory neurons, the retina, specific cells of the lung and in the CNS [1]; developing epithelia of the inner ear, high in granulocytes, lymphopoietic thymus [3] [1] [3]. CN barely detected in erythroid precursors and megakaryocytes [1]. XX FF repressor [1]; FF development of granulocytes and T-cell differentiation and macrophage-dependent cytokine production (defense against pathogens), required for the proper development of inner ear hair cells [3]; FF cooperator of Myc or Pim-1 in tumorigenesis [3]; FF 20 amino-acid, N-terminal repressor domain (SNAG), associated with oncogenesis and human neoplasms [5]; FF position- and orientation-independent active transcriptional repressor [4]; FF Gfi1 releases cells from a G1 block induced by IL-2 withdrawal and is targeted by proviral integration in a number of tumor systems [4]; FF role in stem cell differentiation [2]; XX IN T08711 RelA-p65; human, Homo sapiens. XX MX M00250 V$GFI1_01. MX M01067 V$GFI1_Q6. MX M02010 V$GFI1_Q6_01. XX BS R61066. BS R31946. BS R38395. BS R26763. BS R39882. BS R68020. BS R16947. XX DR TRANSPATH: MO000056186. DR UniProtKB: Q99684; GFI1_HUMAN. XX RN [1]; RE0035152. RX PUBMED: 15718298. RA Vassen L., Fiolka K., Mahlmann S., Moroy T. RT Direct transcriptional repression of the genes encoding the zinc-finger proteins Gfi1b and Gfi1 by Gfi1b. RL Nucleic Acids Res. 33:987-998 (2005). RN [2]; RE0035164. RX PUBMED: 12721361. RA Duan Z., Horwitz M. RT Targets of the transcriptional repressor oncoprotein Gfi-1. RL Proc. Natl. Acad. Sci. USA 100:5932-5937 (2003). RN [3]; RE0035165. RX PUBMED: 15618011. RA Moroy T. RT The zinc finger transcription factor Growth factor independence 1 (Gfi1). RL Int. J. Biochem. Cell Biol. 37:541-546 (2005). RN [4]; RE0035172. RX PUBMED: 8887656. RA Grimes H. L., Chan T. O., Zweidler-McKay P. A., Tong B., Tsichlis P. N. RT The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal. RL Mol. Cell. Biol. 16:6263-6272 (1996). RN [5]; RE0035232. RX PUBMED: 8962093. RA Grimes H. L., Gilks C. B., Chan T. O., Porter S., Tsichlis P. N. RT The Gfi-1 protooncoprotein represses Bax expression and inhibits T-cell death. RL Proc. Natl. Acad. Sci. USA 93:14569-14573 (1996). RN [6]; RE0068548. RX PUBMED: 20226183. RA Jung J. H., Lee S. M., Bae S., Lee S. J., Park I. C., Jin Y. W., Lee J. H., An S. RT Triad 1 induces apoptosis by p53 activation. RL FEBS Lett. 584:1565-1570 (2010). XX //