AC T01930
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ID T01930
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DT 04.11.1996 (created); ewi.
DT 10.07.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA NF-kappaB2-p49
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SY p49.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006466 NFKB2; HGNC: NFKB2.
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CL C0020; Rel; 6.1.1.1.2.3.
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SZ 428 AA; 44.2 kDa (calc.).
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SQ MESCYNPGLDGIIEYDDFKLNSSIVEPKEPAPETADGPYLVIVEQPKQRGFRFRYGCEGP
SQ SHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGIC
SQ AVSVGPKDMTAQFNNLGVLHVTKKNMMGTMIQKLQRQRLRSRPQGLTEAEQRELEQEAKE
SQ LKKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSV
SQ RGGDEVYLLCDKVQKDDIEVRFYEDDENGWQAFGDFSPTDVHKQYAIVFRTPPYHKMKIE
SQ RPVTVFLQLKRKRGGDVSDSKQFTYYPLVEDKEEVQRKRRKALPTFSQPFGGGSHMGGGS
SQ GGAAGGYGGAGGGEGVLMEGGVKVREAVEEKNLGEAGRGLHACNPALWEAKAGRLPEIRS
SQ SRPAWPTA
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SC Swiss-Prot#Q00653-3
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SF the homodimer binds to a kappaB site (of HIV-1 LTR) with KD = 69.1 pM, i. e. with 6-fold lower affinity than p49/p65 heterodimers (KD= 11.8 pM), and even less than p50 homodimers [2];
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CP ubiquitous.
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FF activator when present as heterodimer with RelA (p65) through certain kappaB sites (such as GGGGACTTTCC), but inactive at others (e. g., GGGAATCCC of MHC H-2 genes) despite higher binding affinity [2] [3];
FF the p49/p65 heterodimer is under negative control of IkappaB-alpha [2];
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IN T01930 NF-kappaB2-p49; human, Homo sapiens.
IN T00594 RelA-p65-isoform1; human, Homo sapiens.
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MX M00774 V$NFKB_Q6_01.
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DR TRANSPATH: MO000007897.
DR EMBL: X61499;
DR UniProtKB: Q00653-3; NFKB2_HUMAN.
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RN [1]; RE0001873.
RX PUBMED: 1876189.
RA Schmid R. M., Perkins N. D., Duckett C. S., Andrews P. C., Nabel G. J.
RT Cloning of an NF-kappaB subunit which stimulates HIV transcription in synergy with p65
RL Nature 352:733-736 (1991).
RN [2]; RE0004541.
RX PUBMED: 8441377.
RA Duckett C. S., Perkins N. D., Kowalik T. F., Schmid R. M., Huang E.-S., Baldwin jr A. S., Nabel G. J.
RT Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an IkappaB-alpha (MAD-3)
RL Mol. Cell. Biol. 13:1315-1322 (1993).
RN [3]; RE0004542.
RX PUBMED: 1542644.
RA Perkins N. D., Schmid R. M., Duckett C. S., Leung K., Rice N. R., Nabel G. J.
RT Distinct combinations of NF-kappaB subunits determine the specificity of transcriptional activation
RL Proc. Natl. Acad. Sci. USA 89:1529-1533 (1992).
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//