AC T01941
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ID T01941
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DT 05.11.1996 (created); ewi.
DT 21.01.2010 (updated); pum.
CO Copyright (C), QIAGEN.
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FA NF-kappaB1-isoform6
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SY IkappaBgamma1; NF-kappaB; NF-kappaB1; NF-KB1; NFKB1; nuclear factor of kappa light chain gene enhancer in B-cells 1, p105; p63.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006465 Nfkb1.
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CL C0020; Rel.
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SZ 530 AA; 56.6 kDa (cDNA) (calc.).
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SQ MPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPGPGYGYSNYGFPPYGGITFHPGVTKS
SQ NAGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEGPSLPMACTKTEPIALASTME
SQ DKEQDMGFQDNLFLEKALQLARRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLH
SQ LAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADL
SQ SLLDRWGNSVLHLAAKEGHDRILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSLPCLL
SQ LLVAAGAEVNAQEQKSGRTPLHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAG
SQ RGSTRLAALLKAAGADPLVENFEPLYDLDDSWEKAGEDEGVVPGTTPLDMAANWQVFDIL
SQ NGKPYEPVFTSDDILPQGDMKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGILNNAF
SQ RLSPAPSKTLMDNYEMNSGIVTASVTVVWRHPSANSALQSLLLETAHCYL
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SC translated from EMBL #S89033 and edited
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FT 72 384 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 174 204 
SM00248; ANK_2a.
FT 174 212 
PF00023; Ankyrin repeat.
FT 174 382 
PS50297; ANK_REP_REGION.
FT 213 242 
SM00248; ANK_2a.
FT 213 245 
PF00023; Ankyrin repeat.
FT 213 245 
PS50088; ANK_REPEAT.
FT 246 276 
SM00248; ANK_2a.
FT 246 278 
PS50088; ANK_REPEAT.
FT 246 279 
PF00023; Ankyrin repeat.
FT 282 311 SM00248; ANK_2a.
FT 282 314 PF00023; Ankyrin repeat.
FT 282 314 PS50088; ANK_REPEAT.
FT 316 346 SM00248; ANK_2a.
FT 316 349 PF00023; Ankyrin repeat.
FT 316 349 PS50088; ANK_REPEAT.
FT 350 379 SM00248; ANK_2a.
FT 350 382 PF00023; Ankyrin repeat.
FT 350 382 PS50088; ANK_REPEAT.
FT 437 525 SM00005; DEATH_4.
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SF NF-kappaB1-isoform6 is a 63 kDa isoform, which has a novel 35 AA C-terminus encoded by an alternative reading frame of the p105 gene [1];
SF transcript may arise from an alternative transcription start site directing translation initiation to Met-365 of the p105 precursor [3];
SF splice variants IkappaB-gamma and -gamma2 differ in their C-terminal sequences [1] [2];
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FF specifically acts on the NF-kappaB1 (p50) subunit [1];
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IN T01923 p50; mouse, Mus musculus.
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MX M00194 V$NFKB_Q6.
MX M00774 V$NFKB_Q6_01.
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DR TRANSPATH: MO000016622.
DR EMBL: S89033; S89033.
DR UniProtKB: P25799-6;
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RN [1]; RE0004615.
RX PUBMED: 8183915.
RA Grumont R. J., Gerondakis S.
RT Alternative splicing of RNA transcripts encoded by the murine p105 NF-kappaB gene generates IkappaBgamma isoforms with different inhibitory activities
RL Proc. Natl. Acad. Sci. USA 91:4367-4371 (1994).
RN [2]; RE0004640.
RX PUBMED: 8398903.
RA Gerondakis S., Morrice N., Richadson I. B., Wettenhall R., Fecondo J., Grumont R. J.
RT The activity of a 70 kilodalton I kappa B molecule identical to the carboxyl terminus of the p105 NF-kappa B precursor is modulated by protein kinase A
RL Cell Growth Differ. 4:617-627 (1993).
RN [3]; RE0004750.
RX PUBMED: 1339305.
RA Inoue J.-I., Kerr L. D., Kakizuka A., Verma I. M.
RT IkappaBgamma, a 70 kd protein identical to the C-terminal half of p110 NF-kappaB: A new member of the IkappaB family
RL Cell 68:1109-1120 (1992).
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