AC T00166
XX
ID T00166
XX
DT 01.06.1993 (created); ewi.
DT 19.08.2011 (updated); pum.
CO Copyright (C), QIAGEN.
XX
FA CREB-B
XX
SY cAMP response element-binding protein; CREB-327; CREB-B; CREB-isoform2; deltaCREB.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G004624 CREB1; HGNC: CREB1.
XX
HO ATF-43.
XX
CL C0008; bZIP; 1.1.7.1.1.2.
XX
SZ 327 AA; 35.1 kDa (cDNA) (calc.).
XX
SQ MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPN
SQ GQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSY
SQ RKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLA
SQ NNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQI
SQ RTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENR
SQ VAVLENQNKTLIEELKALKDLYCHKSD
XX
SC edited Swiss-Prot #P16220
XX
FT 23 324 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 87 146 
PS50953; KID.
FT 99 139 
PF02173; pKID domain.
FT 267 325 
SM00338; brlzneu.
FT 267 327 
PF00170; bZIP transcription factor.
FT 269 320 
PS50217; BZIP.
XX
SF basic region;
SF zipper (L4);
XX
CP ubiquitous (placenta).
XX
FF splice variant from CREB (AA 88-101 of CREB missing);
FF only 10% trans-activation capability compared to CREB;
XX
IN T00968 ATF-1; human, Homo sapiens.
IN T01304 ATF-1; mouse, Mus musculus.
IN T00051 ATF; human, Homo sapiens.
IN T00163 CREB-A; human, Homo sapiens.
IN T00166 CREB-B; human, Homo sapiens.
IN T00164 CREB1; rat, Rattus norvegicus.
IN T01385 CREB1; cattle, Bos taurus.
IN T00989 CREB; mouse, Mus musculus.
IN T01127 CREB; pig, Sus scrofa.
IN T01307 CREB; hamster, Cricetulus sp.
IN T01380 CREB; mink, Mustela vison.
XX
MX M07248 V$CREB1_Q3.
MX M03544 V$CREB1_Q6.
MX M00981 V$CREBATF_Q6.
MX M00039 V$CREB_01.
MX M00113 V$CREB_02.
MX M00177 V$CREB_Q2.
MX M00916 V$CREB_Q2_01.
MX M00801 V$CREB_Q3.
MX M00178 V$CREB_Q4.
MX M00917 V$CREB_Q4_01.
MX M00114 V$TAXCREB_01.
MX M00115 V$TAXCREB_02.
XX
BS R00352.
BS R00362.
BS R04110.
BS R04577.
BS R04753.
BS R04578.
BS R04579.
XX
DR TRANSPATH: MO000024746.
DR EMBL: S72459;
DR UniProtKB: P16220-2;
XX
RN [1]; RE0000233.
RX PUBMED: 2137373.
RA Yamamoto K. K., Gonzalez G. A., Menzel P., Rivier J., Montminy M. R.
RT Characterization of a bipartite activator domain in transcription factor CREB
RL Cell 60:611-617 (1990).
RN [2]; RE0001106.
RX PUBMED: 1655749.
RA Rehfuss R. P., Walton K. M., Loriaux M. M., Goodman R. H.
RT The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A
RL J. Biol. Chem. 266:18431-18434 (1991).
RN [3]; RE0001461.
RX PUBMED: 2147221.
RA Hurst H. C., Masson M., Jones N. C., Lee K. A. W.
RT The cellular transcription factor CREB corresponds to activating transcription factor 47 (ATF-47) and forms complexes with a group of polypeptides related to ATF-43
RL Mol. Cell. Biol. 10:6192-6203 (1990).
RN [4]; RE0001639.
RX PUBMED: 2141384.
RA Quinn P. G., Granner D. K.
RT Cyclic AMP-dependent protein kinase regulates transcription of the phosphoenolpyruvate carboxykinase gene but not binding of nuclear factors to the cyclic AMP regulatory element
RL Mol. Cell. Biol. 10:3357-3364 (1990).
RN [5]; RE0002506.
RX PUBMED: 2142528.
RA Berkowitz L. A., Gilman M. Z.
RT Two distinct forms of active transcription factor CREB (cAMP response element binding protein)
RL Proc. Natl. Acad. Sci. USA 87:5258-5262 (1990).
RN [6]; RE0002638.
RX PUBMED: 2974179.
RA Hoeffler J. P., Meyer T. E., Yun Y., Jameson J. L., Habener J. F.
RT Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA
RL Science 242:1430-1433 (1988).
RN [7]; RE0003157.
RX PUBMED: 2196176.
RA Yoshimura T., Fujisawa J.-I., Yoshida M.
RT Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain
RL EMBO J. 9:2537-2542 (1990).
RN [8]; RE0004643.
RX PUBMED: 8355695.
RA Kerppola T. K., Curran T.
RT Selective DNA bending by a variety of bZIP proteins
RL Mol. Cell. Biol. 13:5479-5489 (1993).
RN [9]; RE0005259.
RX PUBMED: 7935435.
RA Krajewski W., Lee K. A. W.
RT A monomeric derivative of the cellular transcription factor CREB functions as a constitutive activator
RL Mol. Cell. Biol. 14:7204-7210 (1994).
XX
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