AC T02506
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ID T02506
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DT 23.07.1998 (created); ewi.
DT 23.07.2015 (updated); sla.
CO Copyright (C), QIAGEN.
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FA MEF-2D-isoform non-muscle
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SY MEF-2D (506 AA form); MEF-2D isoform 1b; MEF-2DA'0 (human); MEF-2DA'0; MEF-2DA'0 (human); MEF2D; MEF2D-isoform non-muscle.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009780 Mef2d.
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CL C0014; MADS.
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SZ 514 AA; 55.0 kDa (cDNA) (calc.).
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SQ MGRKKIQIQRITDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNHSNKLFQYAST
SQ DMDKVLLKYTEYNEPHESRTNADIIETLRKKGFNGCDSPEPDGEDSLEQSPLLEDKYRRA
SQ SEELDGLFRRYGSSVPAPNFAMPVTVPVSNQSSMQFSNPSSSLVTPSLVTSSLTDPRLLS
SQ PQQPALQRNSVSPGLPQRPASAGAMLGGDLNSANGACPSPVGNGYVSARASPGLLPVANG
SQ NSLNKVIPAKSPPPPTHNTQLGAPSRKPDLRVITSQGGKGLMHHLTGDHLDLNNAQRLGV
SQ SQSTHSLTTPVVSVATPSLLSQGLPFSSMPTAYNTDYQLPSAELSSLPAFSSPAGLALGN
SQ VTAWQQPQPPQQPQPPQPPQSQPQPPQPQPQQPPQQQPHLVPVSLSNLIPGSPLPHVGAA
SQ LTVTTHPHISIKSEPVSPSRERSPAPPPPAVFPAARPEPGEGLSSPAGGSYETGDRDDGR
SQ GDFGPTLGLLRPAPEPEAEGSAVKRMRLDTWTLK
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SC Swiss-Prot#Q63943-1
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SF a splice variant is MEF-2D (514 AA form) T02505 [1];
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CP P19 cells differentiated into endodermal cells, undifferentiated P19 cells, C2C12 myotubes, mouse brain (protein level) [2].
CN P19 cells differentiated into neurons (protein level) [2].
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FF synergistic activation of transcription in neurogenic lineages with MASH1 [2];
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IN T27839 BAF250; mouse, Mus musculus.
IN T27820 BAF57; mouse, Mus musculus.
IN T00131 c-Jun; mouse, Mus musculus.
IN T00436 JunB; mouse, Mus musculus.
IN T05750 MafG; mouse, Mus musculus.
IN T00525 MyoD; human, Homo sapiens.
IN T00526 MyoD; mouse, Mus musculus.
IN T00528 myogenin; mouse, Mus musculus.
IN T21459 Pbrm1; mouse, Mus musculus.
IN T14296 Pbx3; mouse, Mus musculus.
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MX M02026 V$MEF2D_Q4.
MX M00941 V$MEF2_Q6_01.
MX M07424 V$MEF2_Q6_03.
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BS R09387.
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DR TRANSPATH: MO000026486.
DR EMBL: S68895;
DR UniProtKB: Q63943-1;
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RN [1]; RE0006953.
RX PUBMED: 8114702.
RA Martin J. F., Miano J. M., Hustad C. M., Copeland N. G., Jenkins N. A., Olson E. N.
RT A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing
RL Mol. Cell. Biol. 14:1647-1656 (1994).
RN [2]; RE0015139.
RX PUBMED: 8900141.
RA Black B.L., Ligon K.L., Zhang Y., Olson E.N.
RT Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family
RL J. Biol. Chem. 271:26659-26663 (1996).
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