AC T02505
XX
ID T02505
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DT 23.07.1998 (created); ewi.
DT 23.07.2015 (updated); sla.
CO Copyright (C), QIAGEN.
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FA MEF-2D-isoform muscle
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SY MEF-2D (514 AA form); MEF-2D isoform 1a; MEF-2DAB; MEF-2DAB (human); MEF2D; MEF2D-isoform muscle.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009780 Mef2d.
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CL C0014; MADS; 5.1.1.1.4.5.
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SZ 514 AA; 55.3 kDa (cDNA) (calc.).
XX
SQ MGRKKIQIQRITDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNHSNKLFQYAST
SQ DMDKVLLKYTEYNEPHESRTNADIIEALHNNDRECESPEVDEAFALTPQTEEKYKKIDEE
SQ KYKKIDEEFDKMMQSYRLASSVPAPNFAMPVTVPVSNQSSMQFSNPSSSLVTPSLVTSSL
SQ TDPRLLSPQQPALQRNSVSPGLPQRPASAGAMLGGDLNSANGACPSPVGNGYVSARASPG
SQ LLPVANGNSLNKVIPAKSPPPPTHNTQLGAPSRKPDLRVITSQGGKGLMHHLNNAQRLGV
SQ SQSTHSLTTPVVSVATPSLLSQGLPFSSMPTAYNTDYQLPSAELSSLPAFSSPAGLALGN
SQ VTAWQQPQPPQQPQPPQPPQSQPQPPQPQPQQPPQQQPHLVPVSLSNLIPGSPLPHVGAA
SQ LTVTTHPHISIKSEPVSPSRERSPAPPPPAVFPAARPEPGEGLSSPAGGSYETGDRDDGR
SQ GDFGPTLGLLRPAPEPEAEGSAVKRMRLDTWTLK
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SC Swiss-Prot#Q63943-2
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FT 1 60 
SM00432; MADS.
FT 1 61 
PS50066; MADS_BOX_2.
FT 9 59 
PF00319; SRF-type transcription factor (DNA-binding a.
FT 37 326 
PF00478; IMP dehydrogenase / GMP reductase domain.
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SF a splice variant is MEF-2D (506 AA form) T02506 [1];
SF gene expression in developing brain see for detailed information [4];
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CP (adult:) high in heart, skeletal muscle, brain, kidney, low in lung, liver, testis [1]; developing brain [4] [4] [1].
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FF expression in embryonic cardiac muscle at 8.5 p.c. [2];
FF expression in skeletal muscle at 9.5 p.c. [2];
FF expression in cerebellum: begins at postnatal day 13, maintains in adults in hippocampus, olfactory bulb [3];
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IN T27839 BAF250; mouse, Mus musculus.
IN T27820 BAF57; mouse, Mus musculus.
IN T16150 BRG1; mouse, Mus musculus.
IN T00131 c-Jun; mouse, Mus musculus.
IN T04140 hdac2; mouse, Mus musculus.
IN T00436 JunB; mouse, Mus musculus.
IN T05750 MafG; mouse, Mus musculus.
IN T00525 MyoD; human, Homo sapiens.
IN T00526 MyoD; mouse, Mus musculus.
IN T00528 myogenin; mouse, Mus musculus.
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MX M02026 V$MEF2D_Q4.
MX M00941 V$MEF2_Q6_01.
MX M07424 V$MEF2_Q6_03.
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BS R09142.
BS R09387.
BS R09229.
BS R09230.
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DR TRANSPATH: MO000026485.
DR EMBL: S68893;
DR UniProtKB: Q63943-2;
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RN [1]; RE0006953.
RX PUBMED: 8114702.
RA Martin J. F., Miano J. M., Hustad C. M., Copeland N. G., Jenkins N. A., Olson E. N.
RT A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing
RL Mol. Cell. Biol. 14:1647-1656 (1994).
RN [2]; RE0014840.
RX PUBMED: 8026334.
RA Edmondson D.G., Lyons G.E., Martin J.F., Olson E.N.
RT Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis
RL Development 120:1251-1263 (1994).
RN [3]; RE0014846.
RX PUBMED: 9013788.
RA Lin X., Shah S., Bulleit R.F.
RT The expression of MEF2 genes is implicated in CNS neuronal differentiation
RL Brain Res. Mol. Brain Res. 42:307-316 (1996).
RN [4]; RE0015071.
RX PUBMED: 7643214.
RA Lyons G.E., Micales B.K., Schwarz J., Martin J.F., Olson E.N.
RT Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation
RL J. Neurosci. 15:5727-5738 (1995).
XX
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