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AC T09395
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ID T09395
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DT 13.02.2015 (updated); pro.
CO Copyright (C), QIAGEN.
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FA IRF-7
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SY interferon regulatory factor 7; IRF-7A; IRF7; IRF7A.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002599 IRF7; HGNC: IRF7.
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CL C0022; trp; 3.5.3.0.7.
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IN T01303 ATF-4; human, Homo sapiens.
IN T19903 DEAF1; human, Homo sapiens.
IN T17026 RNF96; human, Homo sapiens.
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MX M00453 V$IRF7_01.
MX M04019 V$IRF7_04.
MX M01884 V$IRF7_Q3.
MX M03793 V$IRF7_Q3_01.
MX M08887 V$IRF_Q4.
MX M00772 V$IRF_Q6.
MX M00972 V$IRF_Q6_01.
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BS R25556.
BS R37567.
BS R12443.
BS R14454.
BS R25968.
BS R30651.
BS R30654.
BS R30523.
BS R30648.
BS R30649.
BS R66255.
BS R19557.
BS R19558.
BS R14802.
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DR TRANSPATH: MO000007703.
DR UniProtKB: Q92985; IRF7_HUMAN.
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RN [1]; RE0051469.
RX PUBMED: 15767370.
RA Uematsu S., Sato S., Yamamoto M., Hirotani T., Kato H., Takeshita F., Matsuda M., Coban C., Ishii K. J., Kawai T., Takeuchi O., Akira S.
RT Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction.
RL J. Exp. Med. 201:915-923 (2005).
RN [2]; RE0051557.
RX PUBMED: 15361868.
RA Kawai T., Sato S., Ishii K. J., Coban C., Hemmi H., Yamamoto M., Terai K., Matsuda M., Inoue J., Uematsu S., Takeuchi O., Akira S.
RT Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6.
RL Nat. Immunol. 5:1061-1068 (2004).
RN [3]; RE0054898.
RX PUBMED: 17823124.
RA Gatot J. S., Gioia R., Chau T. L., Patrascu F., Warnier M., Close P., Chapelle J. P., Muraille E., Brown K., Siebenlist U., Piette J., Dejardin E., Chariot A.
RT Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF.
RL J. Biol. Chem. 282:31131-31146 (2007).
RN [4]; RE0065700.
RX PUBMED: 18758466.
RA Cao W., Manicassamy S., Tang H., Kasturi S. P., Pirani A., Murthy N., Pulendran B.
RT Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway.
RL Nat. Immunol. 9:1157-1164 (2008).
RN [5]; RE0065785.
RX PUBMED: 19479062.
RA Konno H., Yamamoto T., Yamazaki K., Gohda J., Akiyama T., Semba K., Goto H., Kato A., Yujiri T., Imai T., Kawaguchi Y., Su B., Takeuchi O., Akira S., Tsunetsugu-Yokota Y., Inoue J.
RT TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA.
RL PLoS ONE 4:e5674 (2009).
RN [6]; RE0066125.
RX PUBMED: 17785777.
RA Osterlund P. I., Pietila T. E., Veckman V., Kotenko S. V., Julkunen I.
RT IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genes.
RL J. Immunol. 179:3434-3442 (2007).
RN [7]; RE0066709.
RX PUBMED: 18028425.
RA Zhao X., Nozell S., Ma Z., Benveniste E. N.
RT The interferon-stimulated gene factor 3 complex mediates the inhibitory effect of interferon-beta on matrix metalloproteinase-9 expression.
RL FEBS J. 274:6456-6468 (2007).
RN [8]; RE0069228.
RX PUBMED: 20668674.
RA Higgs R., Lazzari E., Wynne C., Ni Gabhann J., Espinosa A., Wahren-Herlenius M., Jefferies C. A.
RT Self protection from anti-viral responses--Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors.
RL PLoS ONE 5:e11776 (2010).
RN [9]; RE0069246.
RX PUBMED: 20470398.
RA Miyamoto R., Ito T., Nomura S., Amakawa R., Amuro H., Katashiba Y., Ogata M., Murakami N., Shimamoto K., Yamazaki C., Hoshino K., Kaisho T., Fukuhara S.
RT Inhibitor of IkappaB kinase activity, BAY 11-7082, interferes with interferon regulatory factor 7 nuclear translocation and type I interferon production by plasmacytoid dendritic cells.
RL Arthritis Res. Ther. 12:R87 (2010).
RN [10]; RE0070798.
RX PUBMED: 21148039.
RA Liang Q., Deng H., Sun C. W., Townes T. M., Zhu F.
RT Negative regulation of IRF7 activation by activating transcription factor 4 suggests a cross-regulation between the IFN responses and the cellular integrated stress responses.
RL J. Immunol. 186:1001-1010 (2011).
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