AC T02415
XX
ID T02415
XX
DT 17.04.1998 (created); tme.
DT 22.09.2014 (updated); sup.
CO Copyright (C), QIAGEN.
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FA pitx1
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SY Bft (Backfoot); P-OTX; P-Otx (Pituarity Otx related factor); Pituarity homeobox 1; Pituitary Homeobox factor 1, Pitx1; Ptx-1; Ptx1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006561 Pitx1.
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HO bicoid and orthodenticle.
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CL C0006; homeo; 3.1.3.19.1.
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SF not expressed before E8 [2];
SF during organogenesis of the pituarity expression of Ptx-1 is restricted to Rathke's pouch [1];
SF gene is located on chromosome 13 [3] [4];
SF interacts synergistically with Pit-1 T01172 [2];
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CP (embryonic) pituarity, hind limb buds, 1. branchial arch; (adult) pituarity, intestinal (weak).
CN (adult) brain, lung, kidney, heart, liver, pancreas.
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FF induces expression of the pro-opiomelanocortin (POMC) gene [5] [1];
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IN T00131 c-Jun; mouse, Mus musculus.
IN T01172 Pit-1; mouse, Mus musculus.
IN T10042 Pit-1; Mammalia.
IN T08551 SF-1; mouse, Mus musculus.
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MX M01484 V$PITX1_01.
MX M07055 V$PITX1_Q4.
MX M01826 V$PITX1_Q6.
MX M08895 V$PITX_Q4.
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BS R12756.
BS R32861.
BS R32862.
BS R32863.
BS R32864.
BS R32865.
BS R32866.
BS R32820.
BS R33001.
BS R32849.
BS R33025.
BS R64079.
BS R33024.
BS R22965.
BS R04992.
XX
DR TRANSPATH: MO000026402.
DR TRANSCOMPEL: C00215.
DR TRANSCOMPEL: C00216.
DR UniProtKB: P70314;
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RN [1]; RE0006816.
RX PUBMED: 8675014.
RA Lamonerie T., Tremblay J. J., Lanctot C., Therrien M., Gauthier Y., Drouin J.
RT Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene
RL Genes Dev. 10:1284-1295 (1996).
RN [2]; RE0006817.
RX PUBMED: 8755540.
RA Szeto D. P., Ryan A. K., O Connell S. M., Rosenfeld M. G.
RT P-OTX: A PIT-1-interacting homeodomain factor expressed during anterior pituarity gland development
RL Proc. Natl. Acad. Sci. USA 93:7706-7710 (1996).
RN [3]; RE0006818.
RX PUBMED: 9337397.
RA Crawford M. J., Lanctot C., Tremblay J. J., Jenkins N., Gilbert D., Copeland N., Beatty B., Drouin J.
RT Human and murine PTX1/Ptx1 gene maps to the region for Treacher Collins syndrome
RL Mamm. Genome 8:841-845 (1997).
RN [4]; RE0006867.
RX PUBMED: 9070926.
RA Shang J., Li X., Ring H. Z., Clayton D. A., Francke U.
RT Backfoot, a novel homeobox gene, maps to human chromosome 5 (BFT) and mouse chromosome 13 (Bft)
RL Genomics 40:108-113 (1997).
RN [5]; RE0015734.
RX PUBMED: 9371841.
RA Smidt M. P., van Schaick H. S., Lanctot C., Tremblay J. J., Cox J. J., van der Kleij A. A., Wolterink G., Drouin J., Burbach J. P.
RT A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons
RL Proc. Natl. Acad. Sci. USA 94:13305-13310 (1997).
RN [6]; RE0017905.
RX PUBMED: 11328855.
RA Quirk C. C., Lozada K. L., Keri R. A., Nilson J. H.
RT A single Pitx1 binding site is essential for activity of the LHbeta promoter in transgenic mice
RL Mol. Endocrinol. 15:734-746 (2001).
RN [7]; RE0047640.
RX PUBMED: 15226417.
RA Jeong K. H., Chin W. W., Kaiser U. B.
RT Essential role of the homeodomain for pituitary homeobox 1 activation of mouse gonadotropin-releasing hormone receptor gene expression through interactions with c-Jun and DNA.
RL Mol. Cell. Biol. 24:6127-6139 (2004).
RN [8]; RE0068203.
RX PUBMED: 18339718.
RA Lamba P., Khivansara V., D'Alessio A. C., Santos M. M., Bernard D. J.
RT Paired-like homeodomain transcription factors 1 and 2 regulate follicle-stimulating hormone beta-subunit transcription through a conserved cis-element.
RL Endocrinology 149:3095-3108 (2008).
RN [9]; RE0070827.
RX PUBMED: 19995909.
RA Luo Z., Wijeweera A., Oh Y., Liou Y. C., Melamed P.
RT Pin1 facilitates the phosphorylation-dependent ubiquitination of SF-1 to regulate gonadotropin beta-subunit gene transcription.
RL Mol. Cell. Biol. 30:745-763 (2010).
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