AC T01172
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ID T01172
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DT 27.04.1994 (created); ewi.
DT 12.12.2013 (updated); vad.
CO Copyright (C), QIAGEN.
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FA Pit-1
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SY GHF-1; growth hormone factor 1; Pit-1; Pit-1b; pituitary-specific positive transcription factor 1; POU1F1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004568 Pou1f1.
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CL C0007; POU; 3.1.10.1.1.
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CP pituitary gland.
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FF activator, also responsible for establishment and maintenance of the differentiated phenotype of somatotrophs and for proliferation of these cells [6];
FF Pit-1 appearance in somatotrophs coincides with growth hormone expression [4];
FF triggered by cAMP to activate TSH-beta gene transcription in response to TRH [7];
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IN T01964 LHX3a; mouse, Mus musculus.
IN T02415 pitx1; mouse, Mus musculus.
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MX M01465 V$PIT1_01.
MX M00802 V$PIT1_Q6.
MX M03559 V$PIT1_Q6_01.
MX M00744 V$POU1F1_Q6.
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BS R25113.
BS R25114.
BS R25115.
BS R25116.
BS R03100.
BS R03101.
BS R59279.
BS R38551.
BS R27298.
BS R27299.
BS R21399.
BS R20355.
BS R20583.
BS R34779.
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DR TRANSPATH: MO000046039.
DR TRANSCOMPEL: C00362.
DR PATHODB: MT000001.
DR UniProtKB: Q00286; HMP1_MOUSE.
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RN [1]; RE0002474.
RX PUBMED: 1901656.
RA Steinfelder H. J., Hauser P., Nakayama Y., Radovick S., McClaskey J. H., Taylor T., Weintraub B. D., Wondisford F. E.
RT Thyrotropin-releasing hormone regulation of human TSHB expression: Role of a pituitary-specific transcription factor (Pit-1/GHF-1) and potential interaction with a thyroid hormone-inhibitory element
RL Proc. Natl. Acad. Sci. USA 88:3130-3134 (1991).
RN [2]; RE0004422.
RX PUBMED: 1977085.
RA Li S., Crenshaw III E. B., Rawson E. J., Simmons D. M., Swanson L. W., Rosenfeld M. G.
RT Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1
RL Nature 347:528-533 (1990).
RN [3]; RE0004423.
RX PUBMED: 8166682.
RA Jehn B., Chicaiza G., Martin F., Jaggi R.
RT Isolation of three novel POU-domain containing cDNA clones from lactating mouse mammary gland
RL Biochem. Biophys. Res. Commun. 200:156-162 (1994).
RN [4]; RE0004425.
RX PUBMED: 1690079.
RA Dolle P., Castrillo J.-L., Theill L. E., Deerinck T., Ellisman M., Karin M.
RT Expression of GHF-1 protein in mouse pituitaries correlates both temporally and spatially with the onset of growth hormone gene activity
RL Cell 60:809-820 (1990).
RN [5]; RE0004426.
RX PUBMED: 1981057.
RA Camper S. A., Saunders T. L., Katz R. W., Reeves R. H.
RT The Pit-1 transcription factor gene is a candidate for the murine Snell dwarf mutation
RL Genomics 8:586-590 (1990).
RN [6]; RE0004429.
RX PUBMED: 1677216.
RA Castrillo J.-L., Theill L. E., Karin M.
RT Function of the homeodomain protein GHF1 in pituitary cell proliferation
RL Science 253:197-199 (1991).
RN [7]; RE0004437.
RX PUBMED: 1310694.
RA Steinfelder H. J., Radovick S., Mroczynski M. A., Hauser P., McClaskey J. H., Weintraub B. D., Wondisford F. E.
RT Role of a pituitary-specific transcription factor (Pit-1/GHF-1) or a closely related protein in cAMP regulation of human thyrotropin-b subunit gene expression
RL J. Clin. Invest. 89:409-419 (1992).
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