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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T01964 XX ID T01964 XX DT 21.11.1996 (created); ewi. DT 23.11.2009 (updated); ada. CO Copyright (C), QIAGEN. XX FA LHX3a XX SY Lim-3; P-Lim; Xlim-3 (Xenopus). XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G002857 Lhx3. XX HO Gsh-1. XX CL C0025; LIM-homeo; 3.1.5.4.1.1. XX SZ 400 AA; 44.0 kDa (cDNA) (calc.). XX SQ MLLEAELDCHRERPGAPGASALCTFSRTPEIPMCAGCDQHILDRFILKALDRHWHSKCLK SQ CSDCHVPLAERCFSRGESVYCKDDFFKRFGTKCAACQLGIPPTQVVRRAQDFVYHLHCFA SQ CVVCKRQLATGDEFYLMEDSRLVCKADYETAKQREAEATAKRPRTTITAKQLETLKSAYN SQ TSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRNMKRSRGS SQ SKSDKDSIQEGQDSDAEVSFTDEPSMADMGPANGLYSSLGEPAPALGRPVGGLGSFTLDH SQ GGLTGPEQYRELRPGSPYGIPPSPAAPQSLPGPQPLLSSLVYPDTNLSLVPSGPPGGPPP SQ MRVLAGNGPSSDLSTESSSGYPDFPASPASWLDEVDHAQF XX SC translated from EMBL #L33776 XX FT 32 91 PS50023; LIM_DOMAIN_2. FT 33 84 SM00132; lim_4. FT 34 90 PF00412; LIM domain. FT 92 147 SM00132; lim_4. FT 92 154 PS50023; LIM_DOMAIN_2. FT 93 153 PF00412; LIM domain. FT 158 218 PS50071; HOMEOBOX_2. FT 160 222 SM00389; HOX_1. FT 161 217 PF00046; Homeobox domain. FT 161 217 PS50558; LIM_HOMEODOMAIN. XX SF highly homologous to Gsh-1 [1]; SF LIM domain interacts specifically with Pit-1 [1]; SF binds as monomer with minor groove contacts and bends DNA [3]; SF LIM domains reduce binding affinity but not specificity [3]; XX CP adult: high levels in anterior and intermediate lobes of the pituitary, pineal gland, primordia of motor neurons [2] [1] brain, heart, kidney, liver, lung, testis, trigeminal ganglia [2] [1] [1] [2]. XX FF activator, synergizes with Pit-1, not required for basal transcription [1]; FF transcripts appear by stage e9 in Rathke's pouch, also seen in the ventral neural cord, hindbrain, and developing retina; FF subsequently in all five pituitary cell types [1]; FF transcriptional activator [3]; XX IN T01172 Pit-1; mouse, Mus musculus. XX MX M00510 V$LHX3A_01. MX M01971 V$LHX3b_01. MX M01471 V$LHX3_01. XX BS R11390. BS R11391. BS R11392. BS R11393. BS R11394. BS R11395. BS R11396. BS R11397. BS R11398. BS R11399. BS R11400. BS R11401. BS R11402. BS R11403. BS R11404. BS R11405. BS R11406. BS R11407. BS R11408. BS R11409. BS R11410. BS R11411. BS R11412. BS R11413. BS R11414. BS R11415. BS R11416. BS R11417. BS R11418. BS R11419. BS R11420. BS R11421. BS R11422. BS R11423. BS R11424. BS R11425. BS R11426. BS R11427. BS R11428. BS R11429. BS R09043. BS R16187. XX DR TRANSPATH: MO000026057. DR EMBL: L33776; DR UniProtKB: P50481; XX RN [1]; RE0004771. RX PUBMED: 7708713. RA Bach I., Rhodes S. J., Pearse R. V., Heinzel T., Gloss B., Scully K. M., Sawchenko P. E., Rosenfeld M. G. RT P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1 RL Proc. Natl. Acad. Sci. USA 92:2720-2724 (1995). RN [2]; RE0004772. RX PUBMED: 7811383. RA Seidah N. G., Barale J. C., Marcinkiewicz M., Mattei M. G., Day R., Chretien M. RT The mouse homeoprotein mLIM-3 is expressed in cells derived from the neuroepithelium and persists in adult pituitary RL DNA Cell Biol. 13:1163-1180 (1994). RN [3]; RE0017016. RX PUBMED: 11602361. RA Bridwell J. L., Price J. R., Parker G. E., McCutchan Schiller A., Sloop K. W., Rhodes S. J. RT Role of the LIM domains in DNA recognition by the Lhx3 neuroendocrine transcription factor. RL Gene 277:239-250 (2001). XX //