AC T01964
XX
ID T01964
XX
DT 21.11.1996 (created); ewi.
DT 23.11.2009 (updated); ada.
CO Copyright (C), QIAGEN.
XX
FA LHX3a
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SY Lim-3; P-Lim; Xlim-3 (Xenopus).
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002857 Lhx3.
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HO Gsh-1.
XX
CL C0025; LIM-homeo; 3.1.5.4.1.1.
XX
SZ 400 AA; 44.0 kDa (cDNA) (calc.).
XX
SQ MLLEAELDCHRERPGAPGASALCTFSRTPEIPMCAGCDQHILDRFILKALDRHWHSKCLK
SQ CSDCHVPLAERCFSRGESVYCKDDFFKRFGTKCAACQLGIPPTQVVRRAQDFVYHLHCFA
SQ CVVCKRQLATGDEFYLMEDSRLVCKADYETAKQREAEATAKRPRTTITAKQLETLKSAYN
SQ TSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRNMKRSRGS
SQ SKSDKDSIQEGQDSDAEVSFTDEPSMADMGPANGLYSSLGEPAPALGRPVGGLGSFTLDH
SQ GGLTGPEQYRELRPGSPYGIPPSPAAPQSLPGPQPLLSSLVYPDTNLSLVPSGPPGGPPP
SQ MRVLAGNGPSSDLSTESSSGYPDFPASPASWLDEVDHAQF
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SC translated from EMBL #L33776
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FT 32 91 
PS50023; LIM_DOMAIN_2.
FT 33 84 
SM00132; lim_4.
FT 34 90 
PF00412; LIM domain.
FT 92 147 
SM00132; lim_4.
FT 92 154 
PS50023; LIM_DOMAIN_2.
FT 93 153 
PF00412; LIM domain.
FT 158 218 
PS50071; HOMEOBOX_2.
FT 160 222 
SM00389; HOX_1.
FT 161 217 
PF00046; Homeobox domain.
FT 161 217 
PS50558; LIM_HOMEODOMAIN.
XX
SF highly homologous to Gsh-1 [1];
SF LIM domain interacts specifically with Pit-1 [1];
SF binds as monomer with minor groove contacts and bends DNA [3];
SF LIM domains reduce binding affinity but not specificity [3];
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CP adult: high levels in anterior and intermediate lobes of the pituitary, pineal gland, primordia of motor neurons [2] [1] brain, heart, kidney, liver, lung, testis, trigeminal ganglia [2] [1] [1] [2].
XX
FF activator, synergizes with Pit-1, not required for basal transcription [1];
FF transcripts appear by stage e9 in Rathke's pouch, also seen in the ventral neural cord, hindbrain, and developing retina;
FF subsequently in all five pituitary cell types [1];
FF transcriptional activator [3];
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IN T01172 Pit-1; mouse, Mus musculus.
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MX M00510 V$LHX3A_01.
MX M01971 V$LHX3b_01.
MX M01471 V$LHX3_01.
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BS R11390.
BS R11391.
BS R11392.
BS R11393.
BS R11394.
BS R11395.
BS R11396.
BS R11397.
BS R11398.
BS R11399.
BS R11400.
BS R11401.
BS R11402.
BS R11403.
BS R11404.
BS R11405.
BS R11406.
BS R11407.
BS R11408.
BS R11409.
BS R11410.
BS R11411.
BS R11412.
BS R11413.
BS R11414.
BS R11415.
BS R11416.
BS R11417.
BS R11418.
BS R11419.
BS R11420.
BS R11421.
BS R11422.
BS R11423.
BS R11424.
BS R11425.
BS R11426.
BS R11427.
BS R11428.
BS R11429.
BS R09043.
BS R16187.
XX
DR TRANSPATH: MO000026057.
DR EMBL: L33776;
DR UniProtKB: P50481;
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RN [1]; RE0004771.
RX PUBMED: 7708713.
RA Bach I., Rhodes S. J., Pearse R. V., Heinzel T., Gloss B., Scully K. M., Sawchenko P. E., Rosenfeld M. G.
RT P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1
RL Proc. Natl. Acad. Sci. USA 92:2720-2724 (1995).
RN [2]; RE0004772.
RX PUBMED: 7811383.
RA Seidah N. G., Barale J. C., Marcinkiewicz M., Mattei M. G., Day R., Chretien M.
RT The mouse homeoprotein mLIM-3 is expressed in cells derived from the neuroepithelium and persists in adult pituitary
RL DNA Cell Biol. 13:1163-1180 (1994).
RN [3]; RE0017016.
RX PUBMED: 11602361.
RA Bridwell J. L., Price J. R., Parker G. E., McCutchan Schiller A., Sloop K. W., Rhodes S. J.
RT Role of the LIM domains in DNA recognition by the Lhx3 neuroendocrine transcription factor.
RL Gene 277:239-250 (2001).
XX
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