TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01576 XX ID T01576 XX DT 24.11.1995 (created); ewi. DT 27.01.2015 (updated); spk. CO Copyright (C), QIAGEN. XX FA STAT4 XX SY signal transducer and activator of transcription 4. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G006766 Stat4. XX CL C0039; STAT; XX SF length is 749 AA [2]; SF length is 748 AA (199 is missing) and a A638P variation [4]; SF the crystal structure of the dimerizing N-terminal domain reveals the presence of eight alpha-helices [5]; SF the first four helices form a ring-shaped element, alpha4 contains a highly conserved tryptophan residue [5]; SF two of these helices (alpha6 and alpha7) form an antiparallel coiled-coil [5]; SF each alpha6 and alpha7 comprises two conserved heptad repeats of hydrophobic amino acid residues [5]; SF helix 8 is docking to the ring-shaped element [5]; SF the overall structure of the N-terminal domain is that of a hook [5]; SF the dimer exhibits a two-fold symmetry axis with an extensive polar interface [5]; XX CP high levels: testis; moderate in bone marrow, lung, spleen, skeletal muscle, mast and myeloid cell lines [4]. CN brain, heart, intestine, kidney, liver, ovary, oviduct, stomach [4]. EX lung,,,adult; detectable; Northern blot; RNA (undefined); [4]. EX muscles,,,adult; detectable; Northern blot; RNA (undefined); [4]. EX spleen,,,adult; detectable; Northern blot; RNA (undefined); [3]. EX spleen,T-lymphocyte,,adult; detectable. EX testis (right and left),,,adult; detectable; Northern blot; RNA (undefined); [3]. EX thymus,,,adult; detectable; Northern blot; RNA (undefined); [3]. XX FF apparently specifically induced by IL-12 [1]; FF binds to DNA after tyrosine phosphorylation by Jak1 and Jak2 [4]; XX IN T00131 c-Jun; mouse, Mus musculus. XX MX M00498 V$STAT4_01. MX M07131 V$STAT4_02. MX M01666 V$STAT4_Q4. MX M02117 V$STAT4_Q5. MX M00223 V$STAT_01. MX M00777 V$STAT_Q6. XX BS R13241. BS R13242. BS R22537. BS R29787. BS R65366. BS R25764. BS R64502. BS R64504. BS R04650. XX DR TRANSPATH: MO000025778. DR TRANSCOMPEL: C00372. DR UniProtKB: P42228; XX RN [1]; RE0003483. RX PUBMED: 7760829. RA Quelle F. W., Shimoda K., Thierfelder W., Fischer C., Kim A., Ruben S. M., Cleveland J. L., Pierce J. H., Keegan A. D., Nelms K., Paul W. E., Ihle J. N. RT Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosporylated in responses to IL-4 and IL-3 but are not required for mitogenesis RL Mol. Cell. Biol. 15:3336-3343 (1995). RN [2]; RE0003503. RX PUBMED: 8140422. RA Zhong Z., Wen Z., Darnell J. E. RT Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6 RL Science 264:95-98 (1994). RN [3]; RE0003504. RX PUBMED: 7545930. RA Zhong Z., Wen Z., Darnell J. E. RT Stat3 and Stat4: members of the family of signal transducers and activators of transcription RL Proc. Natl. Acad. Sci. USA 91:4806-4810 (1994). RN [4]; RE0003512. RX PUBMED: 8007943. RA Yamamoto K., Quelle F. W., Thierfelder W. E., Kreider B. L., Gilbert D. J., Jenkins N. A., Copeland N. G., Silvennoinen O., Ihle J. N. RT Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation RL Mol. Cell. Biol. 14:4342-4349 (1994). RN [5]; RE0013887. RX PUBMED: 9461439. RA Vinkemeier U., Moarefi I., Darnell jr. J. E., Kuriyan J. RT Structure of the amino-terminal protein interaction domain of STAT-4 RL Science 279:1048-1052 (1998). RN [6]; RE0065726. RX PUBMED: 16698929. RA Chen Z., Laurence A., Kanno Y., Pacher-Zavisin M., Zhu B. M., Tato C., Yoshimura A., Hennighausen L., O'Shea J. J. RT Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. RL Proc. Natl. Acad. Sci. USA 103:8137-8142 (2006). RN [7]; RE0065994. RX PUBMED: 15166220. RA Dumoutier L., Tounsi A., Michiels T., Sommereyns C., Kotenko S. V., Renauld J. C. RT Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling. RL J. Biol. Chem. 279:32269-32274 (2004). RN [8]; RE0066419. RX PUBMED: 11070174. RA Shimoda K., Kato K., Aoki K., Matsuda T., Miyamoto A., Shibamori M., Yamashita M., Numata A., Takase K., Kobayashi S., Shibata S., Asano Y., Gondo H., Sekiguchi K., Nakayama K., Nakayama T., Okamura T., Okamura S., Niho Y., Nakayama K. RT Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function. RL Immunity 13:561-571 (2000). XX //