AC T04994
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ID T04994
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DT 30.11.2001 (created); mas.
DT 09.05.2012 (updated); sup.
CO Copyright (C), QIAGEN.
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FA ZNF76
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SY zinc finger protein 76.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002942 ZNF76; HGNC: znf76.
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CL C0001; CH; 2.3.3.28.1.
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SF 64% amino acid identity to Xenopus Staf T02247 and 63% to human SPF/Staf/ZNF143 T04993 [1];
SF binds the same DNA sequence as ZNF143 T04993 [1];
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CP high level expression in adult kidney, adult liver, adult adrenal, neonatal liver, neonatal testis, neonatal adrenal, neonatal thymus, neonatal kidney, neonatal pancreas, neonatal ovary as analyzed by western blot [3].
EX blood,basophil granulocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; mRNA (poly-A); [1].
EX blood,eosinophil granulocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; mRNA (poly-A); [1].
EX blood,lymphocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; mRNA (poly-A); [1].
EX blood,monocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; mRNA (poly-A); [1].
EX blood,neutrophil granulocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; mRNA (poly-A); [1].
EX colon,,,adult; very low; Northern blot; mRNA (poly-A); [1].
EX ovary (right and left),,,adult; medium; Northern blot; mRNA (poly-A); [1].
EX prostate gland,,,adult; medium; Northern blot; mRNA (poly-A); [1].
EX small intestine,,,adult; low; Northern blot; mRNA (poly-A); [1].
EX spleen,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX testis (right and left),,,adult; very high; Northern blot; mRNA (poly-A); [1].
EX thymus,,,fetal; low; Northern blot; mRNA (poly-A); [1].
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FF similar DNA-binding properties to that of T04993 [1];
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IN T23091 p300; Mammalia.
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MX M06198 V$ZNF76_01.
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BS R38707.
BS R16213.
BS R20726.
BS R33522.
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DR TRANSPATH: MO000028757.
DR UniProtKB: P36508;
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RN [1]; RE0017375.
RX PUBMED: 9705341.
RA Myslinski E., Krol A., Carbon P.
RT ZNF76 and ZNF143 are two human homologs of the transcriptional activator Staf.
RL J. Biol. Chem. 273:21998-22006 (1998).
RN [2]; RE0017376.
RX PUBMED: 1427894.
RA Ragoussis J., Senger G., Mockridge I., Sanseau P., Ruddy S., Dudley K., Sheer D., Trowsdale J.
RT A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11.
RL Genomics 14:673-679 (1992).
RN [3]; RE0049540.
RX PUBMED: 14702349.
RA Grossman C. E., Qian Y., Banki K., Perl A.
RT ZNF143 mediates basal and tissue-specific expression of human transaldolase.
RL J. Biol. Chem. 279:12190-12205 (2004).
RN [4]; RE0050020.
RX PUBMED: 16337145.
RA Zheng G., Yang Y. C.
RT Acetylation and alternative splicing regulate ZNF76-mediated transcription.
RL Biochem. Biophys. Res. Commun. 339:1069-1075 (2006).
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