AC T04993
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ID T04993
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DT 30.11.2001 (created); mas.
DT 09.05.2012 (updated); sup.
CO Copyright (C), QIAGEN.
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FA Staf
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SY SBF; SBF/STAF; selenocysteine tRNA gene transcription activating factor; SPH-binding factor; STAF; zinc finger protein 143; ZNF143.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002925 ZNF143; HGNC: ZNF143.
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CL C0001; CH; 2.3.3.28.2.
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SF 63% amino acid identity to human ZNF76 T04994 [3];
SF binds the same DNA sequence like ZNF76 T04994 [3];
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CP high level expression in adult kidney, adult liver, adult adrenal, neonatal testis, neonatal brain, neonatal spleen, neonatal adrenal, neonatal kidney, neonatal pancreas, neonatal lung, neonatal ovary as analyzed by western blot [4].
EX blood,basophil granulocyte,Circulatory System & Hematopoietic System,adult; very low; Northern blot; mRNA (poly-A); [3].
EX blood,eosinophil granulocyte,Circulatory System & Hematopoietic System,adult; very low; Northern blot; mRNA (poly-A); [3].
EX blood,lymphocyte,Circulatory System & Hematopoietic System,adult; very low; Northern blot; mRNA (poly-A); [3].
EX blood,monocyte,Circulatory System & Hematopoietic System,adult; very low; Northern blot; mRNA (poly-A); [3].
EX blood,neutrophil granulocyte,Circulatory System & Hematopoietic System,adult; very low; Northern blot; mRNA (poly-A); [3].
EX colon,,,adult; very low; Northern blot; mRNA (poly-A); [3].
EX ovary (right and left),,,adult; very high; Northern blot; mRNA (poly-A); [3].
EX prostate gland,,,adult; medium; Northern blot; mRNA (poly-A); [3].
EX small intestine,,,adult; high; Northern blot; mRNA (poly-A); [3].
EX spleen,,,adult; low; Northern blot; mRNA (poly-A); [3].
EX testis (right and left),,,adult; medium; Northern blot; mRNA (poly-A); [3].
EX thymus,,,adult; very low; Northern blot; mRNA (poly-A); [3].
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FF can act on promoters of both mRNA-Type (RNA-Pol II transcribed) and snRNA-type (RNA-Pol II or -Pol III transcribed) [1];
FF therefore obviously two physically and functionally distinct regions (different from DNA binding domain) are responsible [1];
FF stimulates transcription of human IRF-3 gene G002598 [2];
FF binds promoter region of U6 snRNA gene G002927 and seems to stimulate its transcription (probably through R11768) [1];
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MX M00262 V$STAF_01.
MX M00264 V$STAF_02.
MX M05594 V$STAF_04.
MX M05596 V$STAF_05.
MX M07339 V$STAF_Q4_01.
MX M03933 V$ZNF143_03.
MX M04732 V$ZNF143_04.
MX M04747 V$ZNF143_05.
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BS R38707.
BS R32893.
BS R16213.
BS R20726.
BS R38711.
BS R33522.
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DR TRANSPATH: MO000028756.
DR UniProtKB: P52747;
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RN [1]; RE0017373.
RX PUBMED: 9776743.
RA Rincon J. C., Engler S. K., Hargrove B. W., Kunkel G. R.
RT Molecular cloning of a cDNA encoding human SPH-binding factor, a conserved protein that binds to the enhancer-like region of the U6 small nuclear RNA gene promoter
RL Nucleic Acids Res. 26:4846-4852 (1998).
RN [2]; RE0017374.
RX PUBMED: 11724783.
RA Mach C. M., Hargrove B. W., Kunkel G. R.
RT The Small RNA gene activator protein, SphI postoctamer homology-binding factor/selenocysteine tRNA gene transcription activating factor, stimulates transcription of the human interferon regulatory factor-3 gene.
RL J. Biol. Chem. 277:4853-4858 (2002).
RN [3]; RE0017375.
RX PUBMED: 9705341.
RA Myslinski E., Krol A., Carbon P.
RT ZNF76 and ZNF143 are two human homologs of the transcriptional activator Staf.
RL J. Biol. Chem. 273:21998-22006 (1998).
RN [4]; RE0049540.
RX PUBMED: 14702349.
RA Grossman C. E., Qian Y., Banki K., Perl A.
RT ZNF143 mediates basal and tissue-specific expression of human transaldolase.
RL J. Biol. Chem. 279:12190-12205 (2004).
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