AC T09645
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ID T09645
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DT 09.11.2006 (created); kau.
DT 07.02.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA Nrf2-isoform1
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SY NF-E2-related factor 2; NFE2L2; NRF2; nuclear factor, erythroid derived 2, like 2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004136 NFE2L2; HGNC: NFE2L2.
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CL C0008; bZIP; 1.1.1.2.3.1.
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SZ 605 AA; 67.8 kDa (cDNA) (calc.), 96 kDa (SDS)
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SQ MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQE
SQ QLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDALYFDDCM
SQ QLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGM
SQ QQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVG
SQ NCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMP
SQ SPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHS
SQ VESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDA
SQ QCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVD
SQ FNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLL
SQ KEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKP
SQ DVKKN
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SC translated from EMBL #BC011558
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FT 112 522 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 191 204 
Nuclear Export Signal (NES) [5].
FT 495 559 
PF00170; bZIP transcription factor.
FT 495 559 
SM00338; brlzneu.
FT 497 560 
PS50217; BZIP.
FT 552 563 
Nuclear Export Signal (NES) [5].
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IN T01427 p300; human, Homo sapiens.
IN T23091 p300; Mammalia.
IN T08348 RXR-alpha; mouse, Mus musculus.
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MX M07296 V$MAF_Q4.
MX M00983 V$MAF_Q6_01.
MX M02263 V$NFE2L2_01.
MX M07610 V$NRF2_Q3.
MX M00821 V$NRF2_Q4.
MX M07265 V$NRF2_Q4_01.
MX M03835 V$NRF2_Q6.
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BS R02420.
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DR TRANSPATH: MO000091004.
DR EMBL: BC011558; BC011558.
DR EMBL: S74017;
DR UniProtKB: Q16236-1;
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RN [1]; RE0003531.
RX PUBMED: 7937919.
RA Moi P., Chan K., Asunis I., Cao A., Kan Y. W.
RT Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region
RL Proc. Natl. Acad. Sci. USA 91:9926-9930 (1994).
RN [2]; RE0017136.
RX PUBMED: 9195958.
RA Marini M. G., Chan K., Casula L., Kan Y. W., Cao A., Moi P.
RT hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2
RL J. Biol. Chem. 272:16490-16497 (1997).
RN [3]; RE0017304.
RX PUBMED: 10930400.
RA Ikeda Y., Sugawara A., Taniyama Y., Uruno A., Igarashi K., Arima S., Ito S., Takeuchi K.
RT Suppression of rat thromboxane synthase gene transcription by peroxisome proliferator-activated receptor gamma in macrophages via an interaction with NRF2
RL J. Biol. Chem. 275:33142-33150 (2000).
RN [4]; RE0050213.
RX PUBMED: 15601839.
RA Furukawa M., Xiong Y.
RT BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.
RL Mol. Cell. Biol. 25:162-171 (2005).
RN [5]; RE0051048.
RX PUBMED: 17636022.
RA Sun Z., Zhang S., Chan J. Y., Zhang D. D.
RT Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2.
RL Mol. Cell. Biol. 27:6334-6349 (2007).
RN [6]; RE0052144.
RX PUBMED: 17512459.
RA Pi J., Bai Y., Reece J. M., Williams J., Liu D., Freeman M. L., Fahl W. E., Shugar D., Liu J., Qu W., Collins S., Waalkes M. P.
RT Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2.
RL Free Radic. Biol. Med. 42:1797-1806 (2007).
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