AC T08296
XX
ID T08296
XX
DT 24.11.2005 (created); elf.
DT 04.02.2015 (updated); spk.
CO Copyright (C), QIAGEN.
XX
FA Kaiso
XX
SY Hypothetical protein DKFZp686L0369; Kaiso; Zbtb33; zinc finger and BTB domain containing 33; ZNF-kaiso; ZNF348.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G021470 ZBTB33; HGNC: Zbtb33.
XX
CL C0058; CH+BTB/POZ.
XX
SZ 673 AA; 74.6 kDa (cDNA) (calc.).
XX
SQ MESRKLISATDIQYSGSLLNSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQL
SQ FSVAGQVVELSFIRAEIFAEILNYIYSSKIVRVRSDLLDELIKSGQLLGVKFIAELGVPL
SQ SQVKSISGTAQDGNTEPLPPDSGDKNLVIQKSKDEAQDNGATIMPIITESFSLSAEDYEM
SQ KKIIVTDSDDDDDDDVIFCSEILPTKETLPSNNTVAQVQSNPGPVAISDVAPSASNNSPP
SQ LTNITPTQKLPTPVNQATLSQTQGSEKLLVSSAPTHLTPNIILLNQTPLSTPPNVSSSLP
SQ NHMPSSINLLVQNQQTPNSAILTGNKANEEEEEEIIDDDDDTISSSPDSAVSNTSLVPQA
SQ DTSQNTSFDGSLIQKMQIPTLLQEPLSNSLKISDIITRNTNDPGVGSKHLMEGQKIITLD
SQ TATEIEGLSTGCKVYANIGEDTYDIVIPVKDDPDEGEARLENEIPKTSGSEMANKRMKVK
SQ HDDHYELIVDGRVYYICIVCKRSYVCLTSLRRHFNIHSWEKKYPCRYCEKVFPLAEYRTK
SQ HEIHHTGERRYQCLACGKSFINYQFMSSHIKSVHSQDPSGDSKLYRLHPCRSLQIRQYAY
SQ LSDRSSTIPAMKDDGIGYKVDTGKEPPVGTTTSTQNKPMTWEDIFIQQENDSIFKQNVTD
SQ GSTEFEFIIPESY
XX
SC translated from EMBL:BX538016
XX
FT 22 125 
PF00651; BTB/POZ domain.
FT 32 94 
PS50097; BTB.
FT 32 125 
SM00225; BTB_4.
FT 189 483 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 495 517 
SM00355; c2h2final6.
FT 495 522 
PS50157; ZINC_FINGER_C2H2_2.
FT 523 545 
SM00355; c2h2final6.
FT 523 550 
PS50157; ZINC_FINGER_C2H2_2.
FT 551 574 
PF00096; zf-C2H2.
FT 551 574 
SM00355; c2h2final6.
FT 551 579 PS50157; ZINC_FINGER_C2H2_2.
XX
SF N-terminal protein-protein interaction POZ domain and C-terminal DNA-binding domain [1];
XX
FF implicated in development and cancer [1];
FF interaction with cell adhesion cofactor p120ctn with Kaiso through its C-terminus serves to regulate Kaiso DNA binding or transcriptional activity, p120ctn can inhibit Kaiso DNA-binding ability to either recognition site [1];
FF Kaiso plays probably an important and unique role in p120ctn function and signaling [1];
FF transcriptional repressor [1];
XX
IN T23091 p300; Mammalia.
IN T08321 p53-isoform1; human, Homo sapiens.
XX
MX M01119 V$KAISO_01.
MX M03876 V$KAISO_Q2.
XX
BS R41127.
BS R41129.
BS R41131.
BS R41132.
BS R41133.
BS R41134.
BS R41135.
BS R41136.
BS R41137.
BS R23821.
XX
DR TRANSPATH: MO000056591.
DR EMBL: BX538016; HSM806167.
DR UniProtKB: Q86T24; Q8IVP6_HUMAN.
XX
RN [1]; RE0035586.
RX PUBMED: 12087177.
RA Daniel J. M., Spring C. M., Crawford H. C., Reynolds A. B., Baig A.
RT The p120(ctn)-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides.
RL Nucleic Acids Res. 30:2911-2919 (2002).
XX
//