AC T02223
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ID T02223
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DT 24.10.1997 (created); ili.
DT 06.02.2015 (updated); sup.
CO Copyright (C), QIAGEN.
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FA AML2
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SY Acute myeloid leukemia 2 protein; AML2; CBF-alpha 3; CBFA3; Core-binding factor, alpha 3 subunit; PEBP2alphaC1; Polyomavirus enhancer binding protein 2 alpha C subunit; Runt-related transcription factor 3; RUNX3.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003994 RUNX3; HGNC: RUNX3.
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CL C0029; runt; 6.4.1.0.3.
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SF factor was found to be associated with the nuclear matrix [2];
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FF transcription activator [1];
FF associates with beta-subunit protein [1];
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IN T23091 p300; Mammalia.
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MX M01759 V$AML2_01.
MX M01814 V$AML2_Q3.
MX M01854 V$AML2_Q3_01.
MX M07372 V$AML2_Q4.
MX M08866 V$AML_Q4.
MX M00769 V$AML_Q6.
MX M00984 V$PEBP_Q6.
MX M04111 V$RUNX3_03.
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BS R32884.
BS R32764.
BS R41105.
BS R41107.
BS R41109.
BS R20998.
BS R41295.
BS R40382.
BS R41125.
BS R41138.
BS R41139.
BS R65958.
BS R65961.
BS R65962.
BS R38783.
BS R19528.
BS R19529.
BS R38322.
BS R38323.
BS R19530.
BS R32763.
BS R66112.
BS R56001.
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DR TRANSPATH: MO000026238.
DR UniProtKB: Q13761;
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RN [1]; RE0005954.
RX PUBMED: 7622058.
RA Bae S., Takahashi E., Zhang Y., Ogawa E., Shigesada K., Namba Y., Satake M., Ito Y.
RT Cloning, mapping and expression of PEBP2alphaC, a third gene encoding the mammalian Runt domain
RL Gene 159:245-248 (1995).
RN [2]; RE0006488.
RX PUBMED: 9192636.
RA Zeng C., van Wijnen A. J., Stein J. L., Meyers S., Sun W., Shopland L., Lawrence J. B., Penman S., Lian J.B., Stein G. S., Hiebert S. W.
RT Identification of a nuclear matrix targeting signal in leukemia and bone-related AML/CBF-alpha transcription factors
RL Proc. Natl. Acad. Sci. USA 94:6746-6751 (1997).
RN [3]; RE0048110.
RX PUBMED: 16135801.
RA Chi X. Z., Yang J. O., Lee K. Y., Ito K., Sakakura C., Li Q. L., Kim H. R., Cha E. J., Lee Y. H., Kaneda A., Ushijima T., Kim W. J., Ito Y., Bae S. C.
RT RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD.
RL Mol. Cell. Biol. 25:8097-8107 (2005).
RN [4]; RE0048384.
RX PUBMED: 15778373.
RA Trompeter H. I., Gomez-Lozano N., Santourlidis S., Eisermann B., Wernet P., Vilches C., Uhrberg M.
RT Three structurally and functionally divergent kinds of promoters regulate expression of clonally distributed killer cell Ig-like receptors (KIR), of KIR2DL4, and of KIR3DL3.
RL J. Immunol. 174:4135-4143 (2005).
RN [5]; RE0068244.
RX PUBMED: 20801098.
RA Iwatani K., Fujimoto T., Ito T.
RT Cyclin D1 blocks the anti-proliferative function of RUNX3 by interfering with RUNX3-p300 interaction.
RL Biochem. Biophys. Res. Commun. 400:426-431 (2010).
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