AC T13730
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ID T13730
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DT 10.03.2005 (created); nvo.
DT 23.02.2016 (updated); sup.
CO Copyright (C), QIAGEN.
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FA Nrf2
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SY NF-E2-related factor 2; NFE2L2; nuclear factor, erythroid derived 2, like 2.
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OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
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IN T23082 ATF-4; Mammalia.
IN T09446 c-Jun; Mammalia.
IN T15118 CBP; Mammalia.
IN T25841 ERR2-isoform3; human, Homo sapiens.
IN T09447 JunD; Mammalia.
IN T13884 MafK; Mammalia.
IN T23091 p300; Mammalia.
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MX M07296 V$MAF_Q4.
MX M00983 V$MAF_Q6_01.
MX M07610 V$NRF2_Q3.
MX M00821 V$NRF2_Q4.
MX M07265 V$NRF2_Q4_01.
MX M03835 V$NRF2_Q6.
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BS R64417.
BS R29839.
BS R65826.
BS R60107.
BS R60106.
BS R70444.
BS R70445.
BS R70446.
BS R70448.
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DR TRANSPATH: MO000046510.
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RN [1]; RE0022883.
RX PUBMED: 10821856.
RA Ishii T., Itoh K., Takahashi S., Sato H., Yanagawa T., Katoh Y., Bannai S., Yamamoto M.
RT Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages.
RL J. Biol. Chem. 275:16023-16029 (2000).
RN [2]; RE0023127.
RX PUBMED: 11683914.
RA Katoh Y., Itoh K., Yoshida E., Miyagishi M., Fukamizu A., Yamamoto M.
RT Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription.
RL Genes Cells 6:857-868 (2001).
RN [3]; RE0023129.
RX PUBMED: 10644678.
RA Aizencang G. I., Bishop D. F., Forrest D., Astrin K. H., Desnick R. J.
RT Uroporphyrinogen III synthase. An alternative promoter controls erythroid-specific expression in the murine gene.
RL J. Biol. Chem. 275:2295-2304 (2000).
RN [4]; RE0023140.
RX PUBMED: 11991805.
RA Chanas S. A., Jiang Q., McMahon M., McWalter G. K., McLellan L. I., Elcombe C. R., Henderson C. J., Wolf C. R., Moffat G. J., Itoh K., Yamamoto M., Hayes J. D.
RT Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.
RL Biochem. J. 365:405-416 (2002).
RN [5]; RE0031009.
RX PUBMED: 14752028.
RA Ishii T., Itoh K., Ruiz E., Leake D. S., Unoki H., Yamamoto M., Mann G. E.
RT Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal.
RL Circ. Res. 94:609-16 (2004).
RN [6]; RE0036699.
RX PUBMED: 12193649.
RA Dinkova-Kostova A. T., Holtzclaw W. D., Cole R. N., Itoh K., Wakabayashi N., Katoh Y., Yamamoto M., Talalay P.
RT Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
RL Proc. Natl. Acad. Sci. USA 99:11908-13 (2002).
RN [7]; RE0036715.
RX PUBMED: 14517290.
RA Cullinan S. B., Zhang D., Hannink M., Arvisais E., Kaufman R. J., Diehl J. A.
RT Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival
RL Mol. Cell. Biol. 23:7198-209 (2003).
RN [8]; RE0037544.
RX PUBMED: 10419538.
RA Wang Y., Devereux W., Stewart T. M., Casero R. A. Jr.
RT Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene
RL J. Biol. Chem. 274:22095-101 (1999).
RN [9]; RE0044664.
RX PUBMED: 12804587.
RA Husbeck B., Stringer D. E., Gerner E. W., Powis G.
RT Increased thioredoxin-1 inhibits SSAT expression in MCF-7 human breast cancer cells
RL Biochem. Biophys. Res. Commun. 306:469-75 (2003).
RN [10]; RE0046076.
RX PUBMED: 12947090.
RA Bloom D. A., Jaiswal A. K.
RT Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression
RL J. Biol. Chem. 278:44675-82 (2003).
RN [11]; RE0052111.
RX PUBMED: 17920186.
RA Zhou W., Lo S. C., Liu J. H., Hannink M., Lubahn D. B.
RT ERRbeta: a potent inhibitor of Nrf2 transcriptional activity.
RL Mol. Cell. Endocrinol. 278:52-62 (2007).
RN [12]; RE0052113.
RX PUBMED: 17875699.
RA Seng S., Avraham H. K., Jiang S., Yang S., Sekine M., Kimelman N., Li H., Avraham S.
RT The nuclear matrix protein, NRP/B, enhances Nrf2-mediated oxidative stress responses in breast cancer cells.
RL Cancer Res. 67:8596-8604 (2007).
RN [13]; RE0052140.
RX PUBMED: 16923960.
RA Zhang J., Ohta T., Maruyama A., Hosoya T., Nishikawa K., Maher J. M., Shibahara S., Itoh K., Yamamoto M.
RT BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress.
RL Mol. Cell. Biol. 26:7942-7952 (2006).
RN [14]; RE0052271.
RX PUBMED: 16449638.
RA Lo S. C., Hannink M.
RT CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1.
RL Mol. Cell. Biol. 26:1235-1244 (2006).
RN [15]; RE0054049.
RX PUBMED: 18434303.
RA Jain A. K., Mahajan S., Jaiswal A. K.
RT Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2: a novel mechanism in Nrf2 activation.
RL J. Biol. Chem. 283:17712-17720 (2008).
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