AC T08728
XX
ID T08728
XX
DT 21.03.2006 (created); man.
DT 10.09.2014 (updated); pos.
CO Copyright (C), QIAGEN.
XX
FA SKIP
XX
SY BX42-homolog; NCoA-62; SKI-interacting protein; SNW1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G002746 SNW1; HGNC: SNW1.
XX
SZ 536 AA; 61.5 kDa (cDNA) (calc.).
XX
SQ MALTSFLPAPTQLSQDQLEAEEKARSQRSRQTSLVSSRREPPPYGYRKGWIPRLLEDFGD
SQ GGAFPEIHVAQYPLDMGRKKKMSNALAIQVDSEGKIKYDAIARQGQSKDKVIYSKYTDLV
SQ PKEVMNADDPDLQRPDEEAIKEITEKTRVALEKSVSQKVAAAMPVRAADKLAPAQYIRYT
SQ PSQQGVAFNSGAKQRVIRMVEMQKDPMEPPRFKINKKIPRGPPSPPAPVMHSPSRKMTVK
SQ EQQEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQTVHINENFAKLAEALYIADRKARE
SQ AVEMRAQVERKMAQKEKEKHEEKLREMAQKARERRAGIKTHVEKEDGEARERDEIRHDRR
SQ KERQHDRNLSRAAPDKRSKLQRNENRDISEVIALGVPNPRTSNEVQYDQRLFNQSKGMDS
SQ GFAGGEDEIYNVYDQAWRGGKDMAQSIYRPSKNLDKDMYGDDLEARIKTNRFVPDKEFSG
SQ SDRRQRGREGPVQFEEDPFGLDKFLEEAKQHGGSKRPSDSSRPKEHEHEGKKRRKE
XX
SC translated from EMBL #U51432
XX
FT 123 499 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 174 341 
PF02731; SKIP/SNW domain.
FT 201 333 
contains region necessary for interaction with Smad3 T04096 [3].
FT 219 233 
proline-rich sequence [1].
FT 220 338 
contains region critical for interaction with VDR T00885 [1].
FT 252 254 
SNW motif [1].
XX
IN T00040 AR; human, Homo sapiens.
IN T08470 Daxx-isoform1; human, Homo sapiens.
IN T19112 SMRT-xbb2; human, Homo sapiens.
IN T08482 VDR-isoform1; human, Homo sapiens.
IN T31896 VDR; Mammalia.
XX
DR TRANSPATH: MO000079394.
DR EMBL: U51432;
DR UniProtKB: Q13573;
XX
RN [1]; RE0016437.
RX PUBMED: 9632709.
RA Baudino T. A., Kraichely D. M., Jefcoat SC J. r., Winchester S. K., Partridge N. C., MacDonald P. N.
RT Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription
RL J. Biol. Chem. 273:16434-16441 (1998).
RN [2]; RE0045269.
RX PUBMED: 11509665.
RA Zhou S., Hayward S. D.
RT Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex
RL Mol. Cell. Biol. 21:6222-32 (2001).
RN [3]; RE0016440.
RX PUBMED: 11278756.
RA Leong G. M., Subramaniam N., Figueroa J., Flanagan J. L., Hayman M. J., Eisman J. A., Kouzmenko A. P.
RT Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription
RL J. Biol. Chem. 276:18243-18248 (2001).
XX
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