TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T05085 XX ID T05085 XX DT 11.04.2002 (created); mas. DT 12.04.2007 (updated); din. CO Copyright (C), QIAGEN. XX FA Hey1 XX SY cardiovascular helix-loop-helix factor 2; CHF2; hairy and enhancer of split related-1; Herp2; hes-related repressor protein 2 herp2; hesr-1; hesr1; hey1; HRT1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004059 HEY1; HGNC: HEY1. XX CL C0010; bHLH; XX SF belongs to Hairy-related bHLH subfamily (T05085, T05086) with conserved C-terminal motif TE(I/V)GAF [1]; SF deviation from conserved 4-amino-acid code WRPW of Hairy family members: here YRPW (pos. 294-297) [1]; XX FF downregulates expression of its homologue T05084 induced by Notch signaling pathway [4]; FF probably form a new class of Notch signal transducers that should prove to be relevant in various developmental processes [3]; XX IN T00040 AR; human, Homo sapiens. XX MX M08885 V$HAIRYLIKE_Q3. XX DR TRANSPATH: MO000031274. DR UniProtKB: Q9Y5J3; XX RN [1]; RE0017655. RX PUBMED: 10588864. RA Nakagawa O., Nakagawa M., Richardson J. A., Olson E. N., Srivastava D. RT HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments. RL Dev. Biol. 216:72-84 (1999). RN [2]; RE0017656. RX PUBMED: 10860664. RA Steidl C., Leimeister C., Klamt B., Maier M., Nanda I., Dixon M., Clarke R., Schmid M., Gessler M. RT Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family RL Genomics 66:195-203 (2000). RN [3]; RE0017657. RX PUBMED: 10964718. RA Maier M. M., Gessler M. RT Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes RL Biochem. Biophys. Res. Commun. 275:652-660 (2000). RN [4]; RE0017667. RX PUBMED: 11095750. RA Nakagawa O., McFadden D. G., Nakagawa M., Yanagisawa H., Hu T., Srivastava D., Olson E. N. RT Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. RL Proc. Natl. Acad. Sci. USA 97:13655-13660 (2000). RN [5]; RE0049770. RX PUBMED: 15684393. RA Belandia B., Powell S. M., Garcia-Pedrero J. M., Walker M. M., Bevan C. L., Parker M. G. RT Hey1, a mediator of notch signaling, is an androgen receptor corepressor. RL Mol. Cell. Biol. 25:1425-1436 (2005). XX //