AC T05085
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ID T05085
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DT 11.04.2002 (created); mas.
DT 12.04.2007 (updated); din.
CO Copyright (C), QIAGEN.
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FA Hey1
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SY cardiovascular helix-loop-helix factor 2; CHF2; hairy and enhancer of split related-1; Herp2; hes-related repressor protein 2 herp2; hesr-1; hesr1; hey1; HRT1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004059 HEY1; HGNC: HEY1.
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CL C0010; bHLH; 1.2.4.1.8.
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SF belongs to Hairy-related bHLH subfamily (T05085, T05086) with conserved C-terminal motif TE(I/V)GAF [1];
SF deviation from conserved 4-amino-acid code WRPW of Hairy family members: here YRPW (pos. 294-297) [1];
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FF downregulates expression of its homologue T05084 induced by Notch signaling pathway [4];
FF probably form a new class of Notch signal transducers that should prove to be relevant in various developmental processes [3];
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IN T00040 AR; human, Homo sapiens.
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MX M08885 V$HAIRYLIKE_Q3.
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DR TRANSPATH: MO000031274.
DR UniProtKB: Q9Y5J3;
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RN [1]; RE0017655.
RX PUBMED: 10588864.
RA Nakagawa O., Nakagawa M., Richardson J. A., Olson E. N., Srivastava D.
RT HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments.
RL Dev. Biol. 216:72-84 (1999).
RN [2]; RE0017656.
RX PUBMED: 10860664.
RA Steidl C., Leimeister C., Klamt B., Maier M., Nanda I., Dixon M., Clarke R., Schmid M., Gessler M.
RT Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family
RL Genomics 66:195-203 (2000).
RN [3]; RE0017657.
RX PUBMED: 10964718.
RA Maier M. M., Gessler M.
RT Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes
RL Biochem. Biophys. Res. Commun. 275:652-660 (2000).
RN [4]; RE0017667.
RX PUBMED: 11095750.
RA Nakagawa O., McFadden D. G., Nakagawa M., Yanagisawa H., Hu T., Srivastava D., Olson E. N.
RT Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.
RL Proc. Natl. Acad. Sci. USA 97:13655-13660 (2000).
RN [5]; RE0049770.
RX PUBMED: 15684393.
RA Belandia B., Powell S. M., Garcia-Pedrero J. M., Walker M. M., Bevan C. L., Parker M. G.
RT Hey1, a mediator of notch signaling, is an androgen receptor corepressor.
RL Mol. Cell. Biol. 25:1425-1436 (2005).
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