TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T05086 XX ID T05086 XX DT 11.04.2002 (created); mas. DT 07.04.2009 (updated); ach. CO Copyright (C), QIAGEN. XX FA HRT3 XX SY hairy and enhancer of split related protein; hairy-related transcription factor 3; HRT-3. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004061 HEYL; HGNC: HEYL. XX CL C0010; bHLH; XX SF deviation from conserved 4-amino-acid code WRPW of Hairy family members: here YHSW (pos. 315-318) [1]; SF belongs to Hairy-related bHLH subfamily (T05085, T05086) with conserved C-terminal motif TE(I/V)GAF [1]; XX FF downregulates expression of its homologue T05084 induced by Notch signaling pathway [3]; XX DR TRANSPATH: MO000031275. DR UniProtKB: Q9NQ87; XX RN [1]; RE0017655. RX PUBMED: 10588864. RA Nakagawa O., Nakagawa M., Richardson J. A., Olson E. N., Srivastava D. RT HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments. RL Dev. Biol. 216:72-84 (1999). RN [2]; RE0017656. RX PUBMED: 10860664. RA Steidl C., Leimeister C., Klamt B., Maier M., Nanda I., Dixon M., Clarke R., Schmid M., Gessler M. RT Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family RL Genomics 66:195-203 (2000). RN [3]; RE0017667. RX PUBMED: 11095750. RA Nakagawa O., McFadden D. G., Nakagawa M., Yanagisawa H., Hu T., Srivastava D., Olson E. N. RT Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. RL Proc. Natl. Acad. Sci. USA 97:13655-13660 (2000). XX //