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AC T05084
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ID T05084
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DT 11.04.2002 (created); mas.
DT 23.11.2006 (updated); lyn.
CO Copyright (C), QIAGEN.
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FA Hey2
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SY basic helix-loop-helix factor 1; CHF1; gridlock; hairy and enhancer of split related-2; hairy-related transcription factor 2; HERP1; Hes-related repressor protein 1; HRT2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004060 HEY2; HGNC: Hey2.
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HO Hairy (Drosophila).
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CL C0010; bHLH; 1.2.4.1.9.
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SF deviation from conserved 4-amino-acid code WRPW of Hairy family members: here YRPW (pos. 327-330) [1];
SF belongs to Hairy-related bHLH subfamily (T05077, T05085) with conserved C-terminal motif TE(I/V)GAF [1];
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FF negative autoregulation: downregulates expression of its own orthologue T05084 induced by Notch signaling pathway [3];
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MX M08885 V$HAIRYLIKE_Q3.
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DR TRANSPATH: MO000031273.
DR UniProtKB: Q9UBP5;
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RN [1]; RE0017655.
RX PUBMED: 10588864.
RA Nakagawa O., Nakagawa M., Richardson J. A., Olson E. N., Srivastava D.
RT HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments.
RL Dev. Biol. 216:72-84 (1999).
RN [2]; RE0017656.
RX PUBMED: 10860664.
RA Steidl C., Leimeister C., Klamt B., Maier M., Nanda I., Dixon M., Clarke R., Schmid M., Gessler M.
RT Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family
RL Genomics 66:195-203 (2000).
RN [3]; RE0017667.
RX PUBMED: 11095750.
RA Nakagawa O., McFadden D. G., Nakagawa M., Yanagisawa H., Hu T., Srivastava D., Olson E. N.
RT Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.
RL Proc. Natl. Acad. Sci. USA 97:13655-13660 (2000).
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