AC T04465
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ID T04465
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DT 08.05.2001 (created); rio.
DT 15.06.2009 (updated); bjo.
CO Copyright (C), QIAGEN.
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FA JIP1
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SY c-jun-amino-terminal kinase interacting protein 1; c-jun-amino-terminal kinase interacting protein-1; IB-1; IB1; islet-brain 1; islet-brain-1; JIP1; JNK MAP kinase scaffold protein 1; JNK-interacting protein 1; MAPK8IP1; mitogen-activated protein kinase 8-interacting protein 1; PRKM8 interacting protein; PRKM8IP.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002470 MAPK8IP1; HGNC: MAPK8IP1.
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HO JIP1 T04468 (mouse).
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CL C0010; bHLH.
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SF 94% identity to rat IB1 T04466 [1];
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EX blood,basophil granulocyte,Circulatory System & Hematopoietic System,adult; none; Northern blot; mRNA (poly-A); [1].
EX blood,eosinophil granulocyte,Circulatory System & Hematopoietic System,adult; none; Northern blot; mRNA (poly-A); [1].
EX blood,lymphocyte,Circulatory System & Hematopoietic System,adult; none; Northern blot; mRNA (poly-A); [1].
EX blood,monocyte,Circulatory System & Hematopoietic System,adult; none; Northern blot; mRNA (poly-A); [1].
EX blood,neutrophil granulocyte,Circulatory System & Hematopoietic System,adult; none; Northern blot; mRNA (poly-A); [1].
EX brain,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX colon,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX heart,,,adult; low; Northern blot; mRNA (poly-A); [1].
EX kidney (right and left),,,adult; none; Northern blot; mRNA (poly-A); [1].
EX liver,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX lung (right and left),,,adult; none; Northern blot; mRNA (poly-A); [1].
EX muscles,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX ovary (right and left),,,adult; low; Northern blot; mRNA (poly-A); [1].
EX pancreas,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX placenta,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX prostate gland,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX small intestine,,,adult; low; Northern blot; mRNA (poly-A); [1].
EX spleen,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX testis (right and left),,,adult; high; Northern blot; mRNA (poly-A); [1].
EX thymus,,,adult; none; Northern blot; mRNA (poly-A); [1].
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FF candidate gene for diabetes and DEFECT-11 microdeletion syndrome [1];
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IN T02944 Daxx; human, Homo sapiens.
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DR TRANSPATH: MO000032655.
DR PATHODB: MT010870.
DR UniProtKB: Q9UQF2;
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RN [1]; RE0016129.
RX PUBMED: 9933567.
RA Mooser V., Maillard A., Bonny C., Steinmann M., Shaw P., Yarnall D. P., Burns D. K., Schorderet D. F., Nicod P., Waeber G.
RT Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun-amino-terminal kinase interacting protein-1 (JIP-1) gene
RL Genomics 55:202-208 (1999).
RN [2]; RE0023073.
RX PUBMED: 12024021.
RA Buchsbaum R. J., Connolly B. A., Feig L. A.
RT Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade.
RL Mol. Cell. Biol. 22:4073-4085 (2002).
RN [3]; RE0024167.
RX PUBMED: 14765123.
RA Gdalyahu A., Ghosh I., Levy T., Sapir T., Sapoznik S., Fishler Y., Azoulai D., Reiner O.
RT DCX, a new mediator of the JNK pathway.
RL EMBO J. 23:823-832 (2004).
RN [4]; RE0049465.
RX PUBMED: 16273093.
RA Jones R. B., Gordus A., Krall J. A., MacBeath G.
RT A quantitative protein interaction network for the ErbB receptors using protein microarrays.
RL Nature 439:168-174 (2006).
RN [5]; RE0052453.
RX PUBMED: 15998799.
RA Song J. J., Lee Y. J.
RT Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1-MEK-JNK signal transduction pathway during metabolic oxidative stress: a negative feedback loop.
RL J. Cell Biol. 170:61-72 (2005).
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