AC T08469
XX
ID T08469
XX
DT 24.01.2006 (created); jag.
DT 09.04.2015 (updated); mka.
CO Copyright (C), QIAGEN.
XX
FA Nrf2
XX
SY NF-E2 related factor 2; NFE2-related factor 2; NFE2L2; NRF-2; NRF2; nuclear factor, erythroid derived 2, like 2.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G002918 Nfe2l2.
XX
CL C0008; bZIP.
XX
SZ 597 AA; 66.9 kDa (cDNA) (calc.).
XX
SQ MMDLELPPPGLQSQQDMDLIDILWRQDIDLGVSREVFDFSQRQKDYELEKQKKLEKERQE
SQ QLQKEQEKAFFAQFQLDEETGEFLPIQPAQHIQTDTSGSASYSQVAHIPKQDALYFEDCM
SQ QLLAETFPFVDDHESLALDIPSHAESSVFTAPHQAQSLNSSLEAAMTDLSSIEQDMEQVW
SQ QELFSIPELQCLNTENKQLADTTAVPSPEATLTEMDSNYHFYSSISSLEKEVGNCGPHFL
SQ HGFEDSFSSILSTDDASQLTSLDSNPTLNTDFGDEFYSAFIAEPSDGGSMPSSAAISQSL
SQ SELLDGTIEGCDLSLCKAFNPKHAEGTMEFNDSDSGISLNTSPSRASPEHSVESSIYGDP
SQ PPGFSDSEMEELDSAPGSVKQNGPKAQPAHSPGDTVQPLSPAQGHSAPMRESQCENTTKK
SQ EVPVSPGHQKAPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVDDFNEMMSKE
SQ QFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLGHLKDEREKLLREKGENDR
SQ NLHLLKRRLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKPDTKKN
XX
SC translated from EMBL #U70475
XX
FT 98 433 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 487 551 
PF00170; bZIP transcription factor.
FT 487 551 
SM00338; brlzneu.
FT 489 552 
PS50217; BZIP.
XX
IN T05451 BRG1; human, Homo sapiens.
IN T16987 BRG1; Mammalia.
IN T18378 CBP; human, Homo sapiens.
IN T18396 CRBN; mouse, Mus musculus.
IN T13786 KEAP1; rat, Rattus norvegicus.
IN T25824 KEAP1; rat, Rattus norvegicus.
IN T08348 RXR-alpha; mouse, Mus musculus.
IN T08965 RXR-alpha; monkey, Cercopithecus aethiops.
XX
MX M07296 V$MAF_Q4.
MX M00983 V$MAF_Q6_01.
MX M07610 V$NRF2_Q3.
MX M00821 V$NRF2_Q4.
MX M07265 V$NRF2_Q4_01.
MX M03835 V$NRF2_Q6.
XX
BS R66682.
BS R22532.
BS R67075.
XX
DR TRANSPATH: MO000058424.
DR TRANSCOMPEL: C00490.
DR EMBL: U20532;
DR EMBL: U70474;
DR EMBL: U70475;
DR UniProtKB: Q60795;
XX
RN [1]; RE0035897.
RX PUBMED: 15292179.
RA Papaiahgari S., Kleeberger S. R., Cho H. Y., Kalvakolanu D. V., Reddy S. P.
RT NADPH oxidase and ERK signaling regulates hyperoxia-induced Nrf2-ARE transcriptional response in pulmonary epithelial cells.
RL J. Biol. Chem. 279:42302-42312 (2004).
RN [2]; RE0047997.
RX PUBMED: 15870285.
RA Ki S. H., Cho I. J., Choi D. W., Kim S. G.
RT Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression.
RL Mol. Cell. Biol. 25:4150-4165 (2005).
RN [3]; RE0050591.
RX PUBMED: 11439354.
RA Dhakshinamoorthy S., Jaiswal A. K.
RT Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene.
RL Oncogene 20:3906-3917 (2001).
RN [4]; RE0051053.
RX PUBMED: 15367669.
RA Cullinan S. B., Gordan J. D., Jin J., Harper J. W., Diehl J. A.
RT The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase.
RL Mol. Cell. Biol. 24:8477-8486 (2004).
RN [5]; RE0052122.
RX PUBMED: 16551619.
RA Salazar M., Rojo A. I., Velasco D., de Sagarra R. M., Cuadrado A.
RT Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2.
RL J. Biol. Chem. 281:14841-14851 (2006).
RN [6]; RE0052140.
RX PUBMED: 16923960.
RA Zhang J., Ohta T., Maruyama A., Hosoya T., Nishikawa K., Maher J. M., Shibahara S., Itoh K., Yamamoto M.
RT BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress.
RL Mol. Cell. Biol. 26:7942-7952 (2006).
RN [7]; RE0052235.
RX PUBMED: 16785233.
RA He X., Chen M. G., Lin G. X., Ma Q.
RT Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the antioxidant response element enhancer.
RL J. Biol. Chem. 281:23620-23631 (2006).
RN [8]; RE0052325.
RX PUBMED: 17313370.
RA Zhang J., Hosoya T., Maruyama A., Nishikawa K., Maher J. M., Ohta T., Motohashi H., Fukamizu A., Shibahara S., Itoh K., Yamamoto M.
RT Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes.
RL Biochem. J. 404:459-466 (2007).
RN [9]; RE0070335.
RX PUBMED: 21245377.
RA Rada P., Rojo A. I., Chowdhry S., McMahon M., Hayes J. D., Cuadrado A.
RT SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.
RL Mol. Cell. Biol. 31:1121-1133 (2011).
XX
//