AC T01732
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ID T01732
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DT 11.03.1996 (created); ewi.
DT 29.12.2009 (updated); mku.
CO Copyright (C), QIAGEN.
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FA HOXB6
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SY homeo box B6; Hox-2.2; HOX2B; Hu2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G009914 HOXB6; HGNC: HOXB6.
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HO Antp (Drosophila).
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CL C0006; homeo; 3.1.1.6.2.
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CP Expressed in melanocyte and melanoma cell lines like A375, Me1559, Me665/1, Me9742/2, FM713, FM727 and NT2/D1 [5].
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FF HOXB6 (not: HOXB5) may shift hematopoietic differentiation from erythroid to myeloid lineage [3];
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IN T15118 CBP; Mammalia.
IN T18378 CBP; human, Homo sapiens.
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MX M01460 V$HOXB6_01.
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DR TRANSPATH: MO000046018.
DR UniProtKB: P17509; HXB6_HUMAN.
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RN [1]; RE0003901.
RX PUBMED: 2573064.
RA Shen W. F., Largman C., Lowney P., Corral J. C., Detmer K., Hauser C. A., Simonitch T. A., Hack F. M., Lawrence H. J.
RT Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines
RL Proc. Natl. Acad. Sci. USA 86:8536-8540 (1989).
RN [2]; RE0003955.
RX PUBMED: 1672751.
RA Shen W. F., Detmer K., Simonitch Eason T. A., Lawrence H. J., Largman C.
RT Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues
RL Nucleic Acids Res. 19:539-545 (1991).
RN [3]; RE0003961.
RX PUBMED: 1372255.
RA Shen W. F., Detmer K., Mathews C. H. E., Hack F. M., Morgan D. A., Largman C., Lawrence H. J.
RT Modulation of homeobox gene expression alters the phenotype of human hematopoietic cell lines
RL EMBO J. 11:983-989 (1992).
RN [4]; RE0048848.
RX PUBMED: 15269212.
RA Shen W., Chrobak D., Krishnan K., Lawrence H. J., Largman C.
RT HOXB6 protein is bound to CREB-binding protein and represses globin expression in a DNA binding-dependent, PBX interaction-independent process.
RL J. Biol. Chem. 279:39895-39904 (2004).
RN [5]; RE0012439.
RX PUBMED: 8756643.
RA Care A., Silvani A., Meccia E., Mattia G., Stoppacciaro A., Parmiani G., Peschle C., Colombo M. P.
RT HOXB7 constitutively activates basic fibroblast growth factor in melanomas
RL Mol. Cell. Biol. 16:4842-4851 (1996).
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