AC T06376
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ID T06376
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DT 15.12.2004 (created); cch.
DT 07.01.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA ING1
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SY growth inhibitor ING1; inhibitor of growth 1; inhibitor of growth family, member 1; inhibitor of growth protein 1; p33ING1; tumor suppressor ING1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G013653 ING1; HGNC: ING1.
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SF several splicing variants are known, e.g. the most abundant form ING1b T06375 [1];
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FF ING1 binds to AT motifs in the AFP promoter, which seems to inhibit HNF1 binding to that site leading to inhibition of the AFP promoter [1];
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IN T18378 CBP; human, Homo sapiens.
IN T25624 p/CAF; human, Homo sapiens.
IN T05140 trrap; human, Homo sapiens.
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BS R16132.
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DR TRANSPATH: MO000045003.
DR UniProtKB: Q9UK53;
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RN [1]; RE0025249.
RX PUBMED: 14522900.
RA Kataoka H., Bonnefin P., Vieyra D., Feng X., Hara Y., Miura Y., Joh T., Nakabayashi H., Vaziri H., Harris C. C., Riabowol K.
RT ING1 represses transcription by direct DNA binding and through effects on p53.
RL Cancer Res. 63:5785-5792 (2003).
RN [2]; RE0029643.
RX PUBMED: 12015309.
RA Vieyra D., Loewith R., Scott M., Bonnefin P., Boisvert F. M., Cheema P., Pastyryeva S., Meijer M., Johnston R. N., Bazett-Jones D. P., McMahon S., Cole M. D., Young D., Riabowol K.
RT Human ING1 proteins differentially regulate histone acetylation.
RL J. Biol. Chem. 277:29832-9 (2002).
RN [3]; RE0049287.
RX PUBMED: 16607280.
RA Gonzalez L., Freije J. M., Cal S., Lopez-Otin C., Serrano M., Palmero I.
RT A functional link between the tumour suppressors ARF and p33ING1.
RL Oncogene 25:5173 (2006).
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