AC T01067
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ID T01067
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DT 24.02.1994 (created); ewi.
DT 20.04.2015 (updated); sup.
CO Copyright (C), QIAGEN.
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FA AML1
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SY Acute Myeloid Leukemia 1; Acute myeloid leukemia 1 protein; AML1; CBF-alpha 2; CBFA2; Core-binding factor, alpha 2 subunit; PEBP2alphaB; Polyomavirus enhancer binding protein 2 alpha B subunit; Runt-related transcription factor 1; RUNX1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003993 RUNX1; HGNC: RUNX1.
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CL C0029; runt; 6.4.1.0.2.
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SF splice variants are AML1a T02256, AML1b T02245, AML1c T02246, AML1DeltaN T02220;
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FF related to t(8,21) acute myeloid leukemia;
FF cross-regulation between isoforms and family members at the transcriptional level possible [3];
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IN T22468 BCL11A-isoform1; human, Homo sapiens.
IN T08465 C/EBPalpha-isoform1; human, Homo sapiens.
IN T18378 CBP; human, Homo sapiens.
IN T21984 p300; human, Homo sapiens.
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MX M00271 V$AML1_01.
MX M01658 V$AML1_Q4.
MX M07242 V$AML1_Q4_01.
MX M08865 V$AML1_Q4_02.
MX M02084 V$AML1_Q5.
MX M00751 V$AML1_Q6.
MX M08866 V$AML_Q4.
MX M00769 V$AML_Q6.
MX M00984 V$PEBP_Q6.
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BS R04441.
BS R19163.
BS R23967.
BS R05004.
BS R66451.
BS R35403.
BS R35404.
BS R35405.
BS R41873.
BS R23963.
BS R23964.
BS R41295.
BS R27442.
BS R65870.
BS R21196.
BS R66170.
BS R31620.
BS R34822.
BS R31156.
BS R31157.
BS R65873.
BS R65874.
BS R65875.
BS R60225.
BS R65876.
BS R65877.
BS R65958.
BS R65961.
BS R65962.
BS R71371.
BS R32326.
BS R33575.
BS R33576.
BS R56401.
BS R24708.
BS R34436.
BS R19162.
BS R34785.
BS R66686.
BS R37197.
BS R37200.
BS R23683.
BS R41164.
BS R67254.
BS R41165.
BS R41166.
BS R39198.
BS R63243.
BS R63245.
BS R63246.
BS R37602.
BS R37603.
BS R37604.
BS R34819.
BS R56001.
BS R36169.
BS R36171.
BS R36173.
BS R66168.
BS R66169.
BS R37991.
BS R37992.
BS R23517.
BS R34464.
BS R37606.
BS R37608.
BS R37232.
BS R56440.
BS R55944.
BS R60222.
BS R60223.
BS R73866.
BS R14793.
BS R14794.
BS R66166.
BS R66167.
BS R31623.
BS R17046.
BS R37205.
BS R37206.
BS R04644.
BS R73985.
BS R73951.
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DR TRANSPATH: MO000025375.
DR TRANSCOMPEL: C00003.
DR TRANSCOMPEL: C00145.
DR TRANSCOMPEL: C00181.
DR TRANSCOMPEL: C00224.
DR TRANSCOMPEL: C00228.
DR TRANSCOMPEL: C00229.
DR TRANSCOMPEL: C00230.
DR EMBL: D10570;
DR EMBL: D43967;
DR UniProtKB: Q01196;
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RN [1]; RE0002540.
RX PUBMED: 8341710.
RA Ogawa E., Maruyama M., Kagoshima H., Inuzuka M., Lu J., Satake M., Shigesada K., Ito Y.
RT PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene
RL Proc. Natl. Acad. Sci. USA 90:6859-6863 (1993).
RN [2]; RE0006068.
RX PUBMED: 7651838.
RA Miyoshi H., Ohira M., Shimizu K., Mitani K., Hirai H., Imai T., Yokoyama K., Soeda E., Ohki M.
RT Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia
RL Nucleic Acids Res. 23:2762-2769 (1995).
RN [3]; RE0006487.
RX PUBMED: 9238031.
RA Stewart M., Terry A., Hu M., O'Hara M., Blyth K., Baxter E., Cameron E., Onions D. E., Neil J. C.
RT Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): Evidence for a new myc collaborating oncogene
RL Proc. Natl. Acad. Sci. USA 94:8646-8651 (1997).
RN [4]; RE0039427.
RX PUBMED: 9606182.
RA Kitabayashi I., Yokoyama A., Shimizu K., Ohki M.
RT Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation
RL EMBO J. 17:2994-3004 (1998).
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