AC T02246
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ID T02246
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DT 28.10.1997 (created); ili.
DT 31.10.2013 (updated); asv.
CO Copyright (C), QIAGEN.
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FA AML1c
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SY AML-1B; AML1; CBF-alpha 2; CBFA2; PEBP2alphaB; RUNX1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003993 RUNX1; HGNC: RUNX1.
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CL C0029; runt; 6.4.1.0.2.3.
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SZ 250 AA; 27.4 kDa (cDNA) (calc.).
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SQ MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPG
SQ ELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNA
SQ TAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHR
SQ QKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQM
SQ QEEDTAPWRC
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SC Swiss-Prot#Q01196-3
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SF similar to PEBP2alphaB [1];
SF related isoforms are AML1a T02256 and AML1b T02245 [1];
SF this isoform is mentioned as AML-1B in reference [2];
SF associated with the nuclear matrix, nuclear matrix targeting signal is necessary and sufficient for that [2];
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CN brain [1], heart [1] [1].
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FF activator [2];
FF most prominent expression in thymus and spleen [1];
FF related to t(8,21) acute myeloid leukemia;
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MX M00271 V$AML1_01.
MX M01658 V$AML1_Q4.
MX M07242 V$AML1_Q4_01.
MX M08865 V$AML1_Q4_02.
MX M02084 V$AML1_Q5.
MX M08866 V$AML_Q4.
MX M00769 V$AML_Q6.
MX M00984 V$PEBP_Q6.
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BS R05026.
BS R05028.
BS R58650.
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DR TRANSPATH: MO000026254.
DR EMBL: D43969;
DR UniProtKB: Q01196-3;
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RN [1]; RE0006068.
RX PUBMED: 7651838.
RA Miyoshi H., Ohira M., Shimizu K., Mitani K., Hirai H., Imai T., Yokoyama K., Soeda E., Ohki M.
RT Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia
RL Nucleic Acids Res. 23:2762-2769 (1995).
RN [2]; RE0006488.
RX PUBMED: 9192636.
RA Zeng C., van Wijnen A. J., Stein J. L., Meyers S., Sun W., Shopland L., Lawrence J. B., Penman S., Lian J.B., Stein G. S., Hiebert S. W.
RT Identification of a nuclear matrix targeting signal in leukemia and bone-related AML/CBF-alpha transcription factors
RL Proc. Natl. Acad. Sci. USA 94:6746-6751 (1997).
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//